Imaging Research Shared Resource

影像研究共享资源

基本信息

批准号：
10380704
负责人：
Christopher A Flask
金额：
$ 10.42万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380704
关键词：
Accounting Adult Animal Cancer Model Animal Housing Applications Grants Basic Science Bioluminescence Biomedical Engineering Cancer Center Support Grant Cancer Patient Cancer Research Project Caring Cells Childhood Clinic Clinical Clinical Research Communication Comprehensive Cancer Center Cyclotrons Doctor of Philosophy Fingerprint Fluorescence Funding Goals Human Image Image Analysis Individual Infrastructure Journals Magnetic Resonance Imaging Malignant Neoplasms Medical center Methodology Mission NCI Center for Cancer Research Nanotechnology Nature Pathway interactions Patients Pediatrics Positron-Emission Tomography Publications Radiochemistry Radiology Specialty Research Research Institute Research Personnel Resource Sharing Resources Screening for cancer Services Technology Training United States National Institutes of Health Universities University Hospitals anticancer research cancer imaging cancer initiation clinical imaging cost effective design experimental study flasks imaging capabilities imaging facilities imaging system improved in situ imaging in vivo instrumentation member mid-career faculty novel novel therapeutic intervention operation pre-clinical pre-clinical research preclinical imaging programs quantitative imaging radiotracer tumor progression

项目摘要

IMAGING RESEARCH SHARED RESOURCE PROJECT SUMMARY/ABSTRACT The Imaging Research Shared Resource (Imaging SR) is an essential asset to Case Comprehensive Cancer Center (Case CCC) members' research, illustrated by the breadth of scientific program involvement and reflected in the number of investigators who use this SR. Last year alone, over 45 investigators, 54% of whom were Case CCC members, accounting for 71% of total usage, from 6 out of the Center’s 7 Programs used the SR. The mission of the Imaging SR is to provide all cancer investigators with a comprehensive array of preclinical and clinical imaging capabilities to deliver in vivo and in situ imaging assessments of cancer. The Imaging SR is an institutional facility integrating state-of-the-art and comprehensive imaging capabilities both for animal models of cancer, as well as pediatric and adult patients. Enabling these efforts is the Imaging SR’s established operational and administrative infrastructure including a fully equipped preclinical imaging facility with onsite animal housing; a research-dedicated human MRI scanner; as well as research radiochemistry facilities including a cyclotron and multiple hot cells. The Specific Aims of the Imaging SR are to: 1. Provide preclinical and clinical research imaging services to cancer investigators. 2. Provide imaging expertise to design effective cancer imaging experiments. 3. Provide project-specific quantitative image analysis capabilities. 4. Synthesize both conventional and novel radiotracers for PET cancer studies. 5. Train new users in the proper and safe operation of the imaging systems. At last review, the Imaging SR was rated Excellent to Outstanding Merit. Throughout the current funding cycle (2012-2016), the Imaging SR provided services to 83 registered users, 48 (58%) of whom are Case CCC members, representing all 7 of the Case CCC programs. The Imaging SR also has access to the full breadth of imaging resources provided by the Department of Radiology at Case Western Reserve University (CWRU) / University Hospitals (UH) Cleveland Medical Center including multiple clinical imaging scanners. Additional preclinical imaging capabilities are housed at the Lerner Research Institute (LRI) at Cleveland Clinic (CC) including a new preclinical MRI scanner and multiple in vivo bioluminescence and fluorescence scanners. Overall, the Imaging SR presents an efficient and cost-effective opportunity for cancer investigators to comprehensively evaluate novel pathways in cancer initiation and progression as well as new therapeutic strategies and methodologies for early cancer detection with the ultimate goal of improved care and longer lives of cancer patients.

影像研究共享资源项目概要/摘要影像研究共享资源 (Imaging SR) 是病例综合癌症的重要资产中心（案例 CCC）成员的研究，通过科学计划参与的广度和仅去年一年，就有超过 45 名调查员使用此 SR，其中 54% 的调查员使用该 SR。中心 7 个项目中有 6 个项目使用了 Case CCC 会员，占总使用量的 71% SR。成像 SR 的使命是为所有癌症研究人员提供全面的信息。临床前和临床成像能力，可提供癌症的体内和原位成像评估。 Imaging SR 是一家集最先进和综合成像能力于一体的机构设施 Imaging SR 为癌症动物模型以及儿童和成人患者提供了帮助。建立运营和管理基础设施，包括设备齐全的临床前成像设施配有现场动物饲养室；专用于研究的人体核磁共振扫描仪以及研究放射化学；设施包括回旋加速器和多个热室。成像 SR 的具体目标是： 1. 为癌症研究者提供临床前和临床研究影像服务。 2. 提供成像专业知识以设计有效的癌症成像实验。 3.提供针对项目的定量图像分析能力。 4. 合成用于 PET 癌症研究的传统和新型放射性示踪剂。 5. 培训新用户如何正确、安全地操作成像系统。在上次审查中，成像 SR 在整个当前融资周期中被评为优秀至杰出。 (2012-2016)，Imaging SR为83个注册用户提供服务，其中48个(58%)为Case CCC 成员，代表所有 7 个 Case CCC 项目。成像 SR 还可以访问该部门提供的全部成像资源凯斯西储大学 (CWRU) / 克利夫兰大学医院 (UH) 放射科医疗中心包括多个临床成像扫描仪。位于克利夫兰诊所 (CC) 的勒纳研究所 (LRI)，包括一个新的临床前研究中心 MRI 扫描仪和多个体内生物发光和荧光扫描仪总体而言，成像 SR。为癌症研究人员提供了一个有效且具有成本效益的机会来全面评估新的癌症发生和进展的途径以及新的治疗策略和方法早期癌症检测，最终目标是改善癌症患者的护理并延长其寿命。