Translation and Validation of a Radiofrequency-Penetrable PET insert for Simultaneous PET/MRI imaging of Neurological Disorders

用于神经系统疾病同步 PET/MRI 成像的射频可穿透 PET 插入物的转化和验证

基本信息

批准号：
10616704
负责人：
CRAIG S LEVIN
金额：
$ 58.87万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-03 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10616704
关键词：
Address Adherence Adoption Agreement Alzheimer&apos s Disease Alzheimer&apos s disease pathology Amyloid Anatomy Biological Markers Brain Breast Clinic Clinical Coiled Bodies Collection Computer software Data Data Set Dedications Development Diameter Digital Imaging and Communications in Medicine Disease Engineering Ensure Exhibits FDA approved Generations Head Head and neck structure Image Impaired cognition Industry Industry Collaboration Industry Standard Inpatients Institution Ionizing radiation Liver Machine Learning Magnetic Resonance Imaging Marketing Measurement Methods Modality Modeling Modification Motion National Institute on Aging Nerve Degeneration Neurodegenerative Disorders Patients Pelvis Performance Phase Photons Positron-Emission Tomography Radiation Dose Unit Recurrence Research Resolution Scanning Software Validation Standardization Study Subject System Technology Translating Translations Validation Vendor Work clinical translation comparative computerized data processing cost data acquisition data standards design disease classification graphical user interface image reconstruction imaging system improved industry partner innovation nervous system disorder neuroimaging new technology novel pediatric patients radio frequency soft tissue software development stem tau Proteins tau aggregation technology validation translational study transmission process

项目摘要

Project Summary/Abstract We propose the clinical translation and validation of an innovative “radiofrequency (RF) penetrable” dedicated positron emission tomography (PET) insert technology that can be placed within any stand- alone magnetic resonance imaging (MRI) system for acquiring simultaneous PET/MRI data. For this proposal the Stanford team will work with industry partner “PETcoil” to address technical developments required for translational studies, ensure industry level standardization of end user software and technology, and acquire first in-patient simultaneous PET/MRI data using this novel PET insert. PET/MRI exhibits some attractive features. First, combined PET/MRI is uniquely capable of providing excellent anatomical soft tissue contrast and multi-parameter information in a single a scan and, as a result, PET/MR is now commonly used for characterizing disease in regions such as the brain, head and neck, breast, liver and pelvis. Second, MRI does not introduce ionization radiation in a PET/MR study. This significant reduction of radiation dose makes PET/MRI an attractive modality for pediatric patients and those requiring recurring PET studies. Third, PET/MR imaging can occur simultaneously, unlike sequential PET/CT, resulting in temporal in addition to spatial correlation of PET with MR data. Despite these attractive features, the adoption of PET/MRI has been slow since its introduction in 2011. One main reason for this slow adoption is the high cost of procuring an integrated PET/MRI system, which is about $5M for the machine and another $1.5–2M for required room renovations to host the machine. The resulting cost (~$6-7M) is simply not affordable for most institutions. Furthermore, the permanently integrated PET/MR system designs offered by vendors such as GE and Siemens yield sub-optimal spatial resolution and sensitivity performance for the PET system component, especially for neurological imaging applications. The proposed brain-dedicated PET ring offers higher photon sensitivity and spatial resolution, and can be inserted into any existing MR system; thus a user only needs to procure the insert, and MR system modifications or room renovations are not required, reducing the entry costs roughly 10- fold. We have realized a 1st generation brain dedicated PET insert for simultaneous PET/MR and are completing a 2nd generation version, both with a spatial resolution of 2.7x2.7x2.7 mm3 and the latter achieving a photon sensitivity of >6%. In addition, this insert approach is “RF penetrable,” an important and novel concept enabling collection of PET/MR data using the MR system’s built-in body coil for RF transmission through the PET ring insert into the patient, and only a RF receiver coil resides inside the insert, thus facilitating the lower cost insert concept for achieving PET/MR. We will translate and validate the 2nd generation brain PET insert and work with our industry partner to standardize our data processing workflow. If successful, this project will enable more widespread dissemination/accessibility of PET/MRI.

项目概要/摘要我们建议对创新的“射频（RF）可穿透”进行临床转化和验证专用的正电子发射断层扫描（PET）插入技术，可以放置在任何支架内为此，需要单独的磁共振成像 (MRI) 系统来采集同步 PET/MRI 数据。斯坦福大学团队将与行业合作伙伴“PETcoil”合作解决技术开发问题转化研究所需的，确保最终用户软件的行业级标准化技术，并使用这种新型 PET 插入物获取第一个住院患者同步 PET/MRI 数据。首先，组合 PET/MRI 具有独特的能力，能够提供出色的性能。一次扫描即可获得解剖软组织对比度和多参数信息，因此， PET/MR 现在通常用于表征大脑、头部和颈部等区域的疾病，其次，MRI 在 PET/MR 研究中不会引入电离辐射。放射剂量的显着减少使得 PET/MRI 对儿科患者来说成为一种有吸引力的治疗方式第三，与那些需要重复 PET 研究的患者不同，PET/MR 成像可以同时进行。连续 PET/CT，从而产生 PET 与 MR 数据的时间和空间相关性。由于具有这些吸引人的功能，自 2011 年推出以来，PET/MRI 的采用一直进展缓慢。采用速度缓慢的原因是采购集成 PET/MRI 系统的成本很高，大约为 500 万美元用于购买机器，另外 1.5-200 万美元用于用于托管机器所需的房间翻新。由此产生的成本（约 6-700 万美元）对于大多数机构来说根本无法承受。此外，永久的。 GE 和西门子等供应商提供的集成 PET/MR 系统设计产生次优空间 PET 系统组件的分辨率和灵敏度性能，尤其是神经成像所提出的大脑专用 PET 环提供更高的光子灵敏度和空间。分辨率，并且可以插入到任何现有的MR系统中；因此用户只需购买插入件，无需修改 MR 系统或改造房间，将入门成本降低约 10- 我们已经实现了第一代大脑专用 PET 插入物，可同时进行 PET/MR。完成第二代版本，空间分辨率均为 2.7x2.7x2.7 mm3，后者实现 >6% 的光子灵敏度此外，这种插入方法是“射频可穿透的”，这是一个重要的因素。新颖的概念可以使用 MR 系统的内置射频体线圈收集 PET/MR 数据通过插入患者体内的 PET 环进行传输，并且只有 RF 接收器位于线圈内插入，从而促进实现 PET/MR 的低成本插入概念。第二代大脑 PET 插入并与我们的行业合作伙伴合作标准化我们的数据处理如果成功，该项目将使 PET/MRI 得到更广泛的传播/使用。