Intra-Cellular Plasmonic System for Neurons, Exosomes and Animal Cellular Studies

用于神经元、外泌体和动物细胞研究的细胞内等离子体系统

• 批准号: RTI-2018-01009
• 负责人: Packirisamy, Muthukumaran
• 金额: $ 10.93万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642343
• 关键词: Intra; Cellular; Plasmonic; System; Neurons

Even though Concordia houses various state-of-the-art research facilities, a number of crucial studies in the areas of cellular interactions with the nano particles are currently limited due to the dire need for a highly specialized high-resolution sub cellular plasmonic system. Such an equipment would enhance ongoing research on developing of more reliable models and design methods by reducing the degree of uncertainty related to nano-bio interactions and plasmonic sensing methods. The Hyperspectral Imaging system (HIS System 2.7) from Cytoviva offers this leading-edge capacity. No similar equipment is available at Concordia or known partner institutions. Acquiring this equipment would not only advance effective collaboration between engineers, biologists and physicists for future convergence but would also sustain leading-edge research success, strengthen training goals, enhance quality of dissertations, and shorten graduation time. We believe that the understanding of the influence of nano materials on cellular biology is fundamentally critical to the realization of micro or micro-nano integrated devices for biological, cellular and molecular studies. This essential research is complementary to both our engineers and physicists working in the area of microsystems, microfluidics, application of micro-nano integrated systems for bio and chemical applications, as well as for our biologists working in characterizing cellular and molecular interactions. Current research, involving the imaging of cells and tissues and monitoring of metabolic activities, is being done at Concordia to develop microsystems for bio applications including diagnosis of growth hormones in milk and cancer cells. However, the incapability of looking closely at the nano cellular plasmonic interactions is a major setback. The requested equipment surmounts this obstacle by permitting observation of thin sections of biological samples and greatly advancing critical ongoing cellular studies on human cancerous cells and neuron cells. Housed in the optical-bio microsystems lab, the system will be open to on-site and other inter-institutional collaborations across Canada including McGill, UdeM, ETS and École Polytechnique.

即使Concordia包含各种最先进的研究设施纳米颗粒，因为对高分辨率高分辨率的亚细胞等离子系统的迫切需要，这种设备将继续使用更可靠的莫雷尔和设计方法。对于纳米生物的相互作用和等离子传感方法。我们认为，对纳米材料对细胞生物学的理解是重新批评生物，细胞和分子研究的重新审查或或微纳米综合设备。在Concordia上，用于表征细胞相互作用的Micro-Nano集成系统以及用于表征细胞相互作用的我们的Olologist。然而，通过允许观察到人类癌变的callular的批判性细胞研究，近距离观察了纳米的细胞相互作用是纳米细胞相互作用。 UDEM，ETS和ÉolePolytechnique。