Microphotonics and Nano Integrated Bio Microsystems and Applications

微光子学和纳米集成生物微系统及应用

• 批准号: RGPIN-2014-03821
• 负责人: Packirisamy, Muthukumaran
• 金额: $ 3.64万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661383
• 关键词: Microphotonics; Nano; Integrated; Bio; Microsystems

There is always an ever growing demand for miniaturized devices called Lab on Chips (LOC) that can do multiple functions such as sample handling, sample preparation and diagnosis, in a more efficient and economical way. In addition, these LOCs are expected to be sensitive, fast responsive, bio compatible, disposable and portable. Hence, this proposal aims to develop technologies and methods that will enable realization of such devices, through systematic research supported by analytical and experimental methodologies followed by device development. The critical requirements of being highly sensitive and quickly responsive will be addressed by developing integrated microsystems.**Integrated microsystems provide an answer to the problem of rapid pathogenic detection by integrating photonics and nano features. However, there are some critical issues associated with biophotonics, such as miniaturization and portability. The portability of the device is required for in-situ medical detections, while miniaturization is essential for handling smaller sample volumes in order to achieve high throughput. Another bottleneck is the integration of nano features with microdevices in order to enhance the performance. These conditions cannot be satisfied unless a technology to integrate microsystems with microphotonics and nano features is developed. Hence, this grant proposes to develop the field of microphotonics and nano integrated Bio Microsystems which will have vast potential for drug delivery, medical diagnosis, lab-on-a-chip, biodefense, biosensors, point-of-care diagnostic applications, therapeutic micro/nano technologies, microarrays and biochips, bioassays, etc. that would be of great benefit to our society. **On considering the above possibilities, one could anticipate that there will be a great demand for sensors and other devices in high volume at low cost with multi-domain needs. This also makes the present proposal of developing integrated microsystems on silicon and polymer platforms highly relevant. The objective of realizing low cost, efficient and reliable integrated microsystems for various applications through this grant will definitely enhance knowledge in many multi-disciplinary areas such as microfabrication, microphotonics, optical microsystems, micromechanics, bio sensing, microfluidics, etc.**The understanding of influence of material and optical properties in relation to process and design limitations is fundamentally critical to the realization of micro-nano integrated devices for biological, cellular and chemical studies. This proposal will also provide opportunities to do research in multi-disciplinary areas involving engineers, physicists and biologists. The proposed research will also open possibilities for cell sorting, cell trapping, micromechanical and optical cellular studies.**In addition to the creation of research knowledge on various aspects such microphotonics, nano integration, bio-optical integration and suspended microfluidics, process development required for microphotonic elements, in-situ and ex-situ nanosynthesis, micro-nano integration, and Bio Mcrosystems by combining biological and engineering expertise, this research will attract strong interest from industries. **In summary, the development of integrated microsystems that covers a wide spectrum of applications including, aerospace, space, communication, biology, medicine, security, etc., will definitely sophisticate the quality of Canadian life in every possible way, increase the global competitiveness in the product differentiating micro and nano technologies, create new products and possibilities for venture development, and finally increase the economic activities of Canada, through innovation, HQP training and industrial collaboration.

在芯片上（LOC）上，对称为实验室的小型设备的需求总是不断增长，可以以更有效，更经济的方式执行多种功能，例如样品处理，样品制备和诊断。此外，这些LOC有望具有敏感，快速响应，生物兼容，一次性和便携。因此，该提案旨在通过系统的研究和实验方法支持，然后通过设备开发来开发系统研究，从而开发能够实现此类设备的技术和方法。 高度敏感和快速响应的关键要求将通过开发集成的微型系统来解决。但是，存在一些与生物素化学有关的关键问题，例如小型化和便携性。该设备的可移植性是原位医疗检测所需的，而微型化对于处理较小的样品体积以实现高吞吐量至关重要。另一个瓶颈是将纳米特征与微型发行的集成在一起，以增强性能。除非开发了将微生系统与麦粒体和纳米特征相结合的技术，否则无法满足这些条件。因此，该赠款建议开发麦粒类药物和纳米综合生物系统的领域，这些系统将具有巨大的药物输送潜力，医学诊断，实验室芯片，生物探测器，生物传感器，生物传感器，护理诊断，治疗诊断， /纳米技术，微阵列和生物芯片，生物测定等对我们的社会带来的巨大好处。 **在考虑上述可能性时，可以预料到，以低成本和多域需求，对传感器和其他设备的需求很大。这也使目前的建议在硅和聚合物平台上开发集成的微型系统高度相关。实现低成本，高效且可靠的集成微系统针对各种应用程序的目标肯定会增强许多多学科领域的知识，例如微生体，微生物学，光学微型系统，微观力学，生物传感，微流体等。与过程和设计局限性有关的材料和光学性质的影响对于生物，细胞和化学研究的微纳米综合设备的实现至关重要。该提案还将提供在涉及工程师，物理学家和生物学家的多学科领域进行研究的机会。拟议的研究还将为细胞分类，细胞捕获，微力机电和光学细胞研究开放。对于微功能元素，原位和原位纳米合成，微纳米整合以及生物MCROSYSTEMS通过结合生物学和工程专业知识，这项研究将引起行业的强烈兴趣。 **总而言之，涵盖广泛应用的综合微型系统的开发，包括航空航天，空间，通信，生物学，医学，安全，安全等等，肯定会以各种可能的方式复杂地提高加拿大生活的质量，并增加全球在产品中竞争性的竞争力来区分微型和纳米技术，创造新产品和风险开发的可能性，并最终通过创新，HQP培训和工业合作来增加加拿大的经济活动。