Convergence through micro-nano-bio integration and applications

微纳生物融合与应用

• 批准号: RGPIN-2019-06999
• 负责人: Packirisamy, Muthukumaran
• 金额: $ 4.66万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=760520
• 关键词: Convergence; through; micro; nano; bio

As per Nobel Laureate Philip Sharp, the third revolution in life sciences that can tackle existing challenges in studying Brain and nervous systems, cardiovascular systems, cancer diagnosis, commercializing of ideas from lab to clinics or training of personnel can happen only through collaboration of life scientists, physical scientists and engineers. Micro-Nano-Bio integration, which is the bridging of bio sciences with micro and nano technologies, is one of the ways of implementing this convergence. Micro-nano-bio integration is a technology to enhance the performance of bio interactions in lab on chips by integrating nano features. In simple terms, the biological and chemical species, such as, cells, proteins, DNA, enzymes, antigen, antibody, etc. can be considered as micro or nano machines that interact with environments. The effects of these interactions could change the mechanical, optical, physical, chemical and biological properties of the environment. These interactions produce output signals and responses that are very low in strength making it very difficult to be detected by conventional means as they need sensing mechanisms that have to be very close to the interaction zone with very high sensitivity and high throughput. Another very important consideration to detect these interactions is non-invasive requirement so that interactions are not influenced by the sensing mechanism itself. One can foresee now that there is an urgent need to develop devices and mechanisms that would have close proximity, optical means of sensing, multiplicity in fabrication for cost-effectiveness and are also very small, very sensitive with low detection level and compatible with biological species. Hence, this application plans to develop many technologies such as (i) microfluidic and nano-integrated planar optical waveguide based technologies suitable for communication and sensing (ii) polymer nano composites that have great potential for chemical and biosensing (iii) 3D suspended polymer microfluidics that is ideal for sensitive physical sensing, mechanobiological studies of cells, fluid sensing, biosensing and chemical sensing, and (iv) Lab on chips with nano-bio interactions for biological applications. In addition to the creation of fundamental research knowledge in the area of convergence on various aspects combining biological and engineering expertise, this research will also attract strong interest from industries due to its applied nature. In nutshell, the development of micro-nano-bio integration that covers a wide spectrum of applications including defence, biology, medicine, security, communications, etc, will definitely sophisticate the quality of Canadian life in every possible way, increase the global competitiveness in the product differentiating micro-nano technologies, create new products and possibilities for venture development, and finally increase the economic activities of Canada, through innovation, training and collaboration.

根据诺贝尔奖获得者菲利普·夏普（Philip Sharp），生命科学的第三次革命可以应对研究大脑和神经系统，心血管系统，癌症诊断，从实验室到诊所进行商业化或人员培训的商业化，只有通过生活科学家的协作才能发生，物理科学家和工程师。 Micro-Nano-Bio Integration是使用微科学与微科学和纳米技术的桥接，是实施这种融合的方法之一。微型纳米生物的集成是一种通过集成纳米功能来增强实验室中实验室中生物相互作用的性能的技术。简而言之，可以将生物学和化学物种（例如细胞，蛋白质，DNA，酶，抗原，抗体等）视为与环境相互作用的微型或纳米机器。这些相互作用的影响可能会改变环境的机械，光学，物理，化学和生物学特性。这些相互作用产生的输出信号和响应的强度非常低，因此很难被传统手段检测到非常困难，因为它们需要具有非常高灵敏度和高吞吐量的相互作用区域的感应机制。检测这些相互作用的另一个非常重要的考虑因素是非侵入性要求，因此相互作用不受感应机制本身的影响。现在可以预见的是，迫切需要开发具有紧密近端的设备和机制，感应的光学手段，用于成本效益的制造中的多重性，并且非常小，非常敏感，并且非常敏感，并且与生物物种相兼容，并且。因此，该应用计划计划开发许多技术，例如（i）微流体和纳米集成平面光学波导的技术，适用于通信和感应（II）聚合物纳米复合材料，具有化学和生物效果的巨大潜力（III）3D悬浮的Polymer MicroFluidics这是对敏感的物理感测，细胞的机械生物学研究，液体感测，生物传感和化学感应的理想选择，以及（iv）实验室在具有生物应用的纳米生物相互作用的芯片上。除了在结合生物学和工程专业知识的各个方面建立融合领域的基本研究知识外，由于其应用性质，这项研究还将引起行业的强烈兴趣。简而言之，涵盖包括国防，生物学，医学，安全，通讯等各种应用程序的微纳米生命整合的发展，肯定会以各种可能的方式复杂地提高加拿大生活的质量，增强全球竞争力该产品通过创新，培训和协作来区分微纳米技术，为风险开发创造新产品和风险开发的可能性，并最终增加加拿大的经济活动。