Gated Optical DetectorsDose Guided Radiotherapy

门控光学探测器剂量引导放射治疗

• 批准号: 7733063
• 负责人: Robert Miller
• 金额: $ 20.56万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733063
• 关键词: Agreement; Dependence; Development; Dose; Fiber; Film; Film Dosimetry; Generations; Glass; Individual; Institution; Legal patent; Length; Licensing; Light; Link; Maps; Measurement; Measures; Methods; Molecular; Optics; Organ; Output; Patients; Phase; Photons; Physiologic pulse; Positioning Attribute; Process; Production; Pulse taking; Radiation; Radiation therapy; Range; Reference Values; Relative (related person); Signal Transduction; Speed; System; Technology; Time; Vendor; base; detector; dosimetry; electron radiation; in vivo; luminescence; nanoparticle; particle; prototype; response; size

All phantom studies with the existing prototype detector system have been completed. The system was also used successfully to measure the output factor of newly acquired stereotactic applicators with very small apertures. The measurements were validated with Monte Carlo calculations as well as with radiochromic film. This project has reached its until a commercial prototype is produced. The original company selected for this task was unable to complete such a unit in the allotted time frame and has defaulted on the terms of its agreement. NRL is in the process of selecting a new company, but until this is done and the new company can produce a workable unit, this project cannot progress further. Once this happens, there are 2 additional follow-on projects: (1) a three phase project to develop a detector array for dose-guided radiotherapy, or DGR. Phase I is to develop an array of fibers as either a rectangular or spiral grid and study the dose map generated during radiotherapy and the effect of small changes in organ or beam positioning. Phase II is to understand the meaning of signal change relative to the patient's anatomical position and to interrupt the treatment if detected signals differ from reference values by a predetermined tolerance margin. Phase III is to dynamically link the changes in grid signals to corrective changes in the radiation field for on-line, dynamic dose control of radiation treatments. (2) a separate project to develop a film-based OSL dosimeter as a replacement for photographic film for dosimetry measurements. Preliminary measurements using ground OSL glass dispersed on a film substrate with a binder were promising, but better methods must be found to produce OSL particles that are uniform in size. One possible approach is to employ nanoparticles incorpoprating OSL molecular chains, and we are currently partnering with an academic institution to explore this possibility.

现有原型探测器系统的所有模型研究均已完成。 该系统还成功用于测量新购置的孔径非常小的立体定向涂药器的输出系数。测量结果通过蒙特卡罗计算以及放射变色薄膜进行了验证。该项目已达到预期目标，直至生产出商业原型。最初选择执行此任务的公司无法在规定的时间内完成该单元，并且违约了其协议条款。 NRL 正在选择一家新公司，但在这一步完成并且新公司能够生产出可用的装置之前，该项目无法进一步进展。一旦发生这种情况，还有 2 个额外的后续项目：(1) 一个三阶段项目，开发用于剂量引导放射治疗 (DGR) 的探测器阵列。第一阶段是开发矩形或螺旋网格形式的纤维阵列，并研究放射治疗期间生成的剂量图以及器官或射束定位的微小变化的影响。第二阶段是了解信号变化相对于患者解剖位置的含义，并在检测到的信号与参考值相差预定容差范围时中断治疗。第三阶段是将网格信号的变化动态地链接到辐射场的校正变化，以实现放射治疗的在线、动态剂量控制。 (2) 一个单独的项目，开发基于胶片的 OSL 剂量计，以替代用于剂量测量的照相胶片。使用用粘合剂分散在薄膜基材上的磨光 OSL 玻璃进行的初步测量是有希望的，但必须找到更好的方法来生产尺寸均匀的 OSL 颗粒。一种可能的方法是采用结合 OSL 分子链的纳米颗粒，我们目前正在与一家学术机构合作探索这种可能性。