The neural network of OCD, linking NHP and human studies

连接 NHP 和人类研究的强迫症神经网络

• 批准号: 9069072
• 负责人: Suzanne N Haber
• 金额: $ 31.87万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9069072
• 关键词: Abbreviations; Affect; Amygdaloid structure; Animals; Anisotropy; Anterior; Area; Basal Ganglia; Behavior; Biological Neural Networks; Brain; Cognitive; Corpus Callosum; Corpus striatum structure; Data; Diffusion Magnetic Resonance Imaging; Dorsal; Emotional; Emotions; Fiber; Functional disorder; Goals; Human; Internal Capsule; Link; Location; Monkeys; Motor; Motor Cortex; Obsessive-Compulsive Disorder; Pathway interactions; Patients; Positioning Attribute; Prefrontal Cortex; Radial; Testing; Tracer; Travel; Ventral Striatum; anatomical tracing; base; cingulate cortex; cingulotomy; cognitive control; cognitive system; frontal lobe; human subject; insight; motor control; neuroregulation; nonhuman primate; research study; white matter

Project Summary The pathophysiology of Obsessive Compulsive Disorder (OCD) is associated with dysfunction in prefrontal cortical and basal-ganglia circuits, in particular the dorsal anterior cingulate cortex (dACC), orbital frontal cortex (OFC), ventrolateral prefrontal cortex (vlPFC) and dorsal striatum. These areas are linked to regions involved in both emotion (amygdala (amyg) and ventromedial PFC (vmPFC)) and higher cognitive and motor control (dorsolateral PFC (dlPFC) and presupplementary motor cortex (pSMA)), placing them in a pivotal position for bottom-up and top-down control for adapting behaviors appropriately. The dACC, vlPFC, and OFC fibers are connected by the cingulum bundle (CB), corpus callosum (CC) and uncinate fasciculus (UF). These white matter (WM) bundles, along with the internal capsule (IC) also show abnormalities in OCD. The overall goal of P1 is to determine the connectivity between the dACC, vlPFC, OFC, and striatum, and the amyg/vmPFC, and the dlPFC/ pSMA. We will use these data to explore connectivity abnormalities in OCD and the effects of noninvasive stimulation and cingulotomy on the WM. Our first hypothesis is that within the dACC, OFC, vlPFC, and striatum, there are specific regions (referred to as critical nodes) that contain converging terminal fields from each other, and from the amyg and/or vmPFC, and from the dlPFC and/or pSMA. These critical nodes would provide an anatomical substrate for modulation between emotional and cognitive systems. Our second hypothesize is that the abnormalities in the WM found in OCD will be located within specific WM segments that connect the critical nodes. Aim 1 will determine where critical nodes are located within the dACC, vlPFC, and OFC and aim 2 will segment the CB, CC, UF, and IC based on where node connections travel. Aims 1 and 2 combine tracer experiments and diffusion MRI (dMRI) animals and dMRI in humans to locate the nodes and segment the WM. Aim 3 will use the segmentation of WM is to evaluate more specifically connectivity differences between OCD and healthy subjects and changes due to neuromodulation. The combination of anatomical and dMRI experiments will provide a translational link for understanding the structural underpinnings of connectivity changes associated with OCD.

项目摘要 强迫症（OCD）的病理生理学与前额叶功能障碍有关 皮质和基底囊式电路，尤其 （OFC），腹外侧前额叶皮层（VLPFC）和背纹状体。这些领域与涉及的地区有关 在情感（杏仁核（Amyg）和腹侧PFC（VMPFC））中，以及更高的认知和运动控制 （背外侧PFC（DLPFC）和预设运动皮层（PSMA）），将它们放在关键位置的位置 适当适当调整行为的自下而上和自上而下的控制。 DACC，VLPFC和OFC纤维是 由c束（CB），callosum callosum（CC）和Uncinate fasciculus（UF）连接。这些白色 物质（WM）束，以及内部胶囊（IC）也显示出强迫症的异常。总体目标 P1是确定DACC，VLPFC，OFC和Striatum和Amyg/vmpfc和 DLPFC/ PSMA。我们将使用这些数据来探索强迫症的连通性异常以及 WM上的非侵入性刺激和扣带切开术。我们的第一个假设是在DACC，OFC，VLPFC中， 和纹状体，有特定区域（称为关键节点）包含收敛的终端场 彼此，来自Amyg和/或VMPFC，以及DLPFC和/或PSMA。这些关键节点 将为情绪和认知系统之间的调节提供解剖基板。我们的第二个 假设是，OCD中发现的WM的异常将位于特定的WM段中 连接关键节点。 AIM 1将确定关键节点位于DACC，VLPFC和 OFC和AIM 2将根据节点连接的位置进行分割CB，CC，UF和IC。目标1和2 将示踪剂实验和扩散MRI（DMRI）动物和DMRI组合在人类中，以定位节点和 细分Wm。 AIM 3将使用WM的分割是为了评估更具体的连接性 强迫症和健康受试者之间的差异以及神经调节引起的变化。结合 解剖学和DMRI实验将为理解结构性提供转化链接 连通性变化的基础与强迫症相关。