Clinical Radiation Physics Service

临床放射物理服务

• 批准号: 8763815
• 负责人: Robert Miller
• 金额: $ 36.17万
• 依托单位: DIVISION OF CLINICAL SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763815
• 关键词: Brachytherapy; Caliber; Calibration; Clinical; Clinical Protocols; Clinical Trials; Collimator; Complex; Consultations; Dose-Rate; Ensure; Equipment; Facility Designs; Funding; Future; Goals; Guidelines; Image; Immobilization; Implant; Institutes; Intensity-Modulated Radiotherapy; Linear Accelerator Radiotherapy Systems; Maintenance; Manufacturer Name; Measurement; Mission; Motion; Patients; Physics; Plant Leaves; Positioning Attribute; Process; Radiation; Radiation Oncology; Radiation Physics; Radiation therapy; Radiosurgery; Research; Scanning; Schedule; Series; Services; Site; Slice; Source; System; Technology; Testing; Twin Multiple Birth; Water; Width; base; data acquisition; improved; in vivo; interstitial; quality assurance; radiofrequency; respiratory; treatment planning

We have instituted routine dynamic Intensity Modulated Radiation Therapy (dIMRT). This is the most complex of IMRT treatments and requires considerable pre-treatment verification to ensure accurate execution. These treatments are delivered using our twin Clinac-21EX accelerators. A Hi-ART system (Tomotherapy Inc.) for delivering treatments via helical tomotherapy has been installed, accepted and is currently treating patients. This system provides ROB with cutting edge treatment technology to support future clinical trials. We have started a series of initiatives with our Nucletron High Dose-Rate Afterloader (HDR) , using a small, high intensity 192Ir source for interstitial and intercavitary brachytherapy. Our radiosurgery capability has been expanded with the acquisition of 3 new applicators with diameters of 5mm, 7.5mm and 10mm. A new Philips Brilliance 16 slice, large bore CT Simulator has received couch control upgrades. On-board imaging (OBI) has been installed on the newer Clinac-21EX. The final component of the Varian RPM Respiratory Gating system for providing gated radiation therapy has been acquired and we are awaiting delivery. Respiratory gating will improve targeting ability by compensating for regular respiratory motions during treatment. We have acquired two state-of-the-art scanning water phantoms, one for CT and Tomotherapy and the second for general accelerator use. These should greatly facilitate data acquisition for annual quality assurance as well as for research purposes. We have also had funding approved for the replacement of our oldest linear accelerator with a new unit. We are in the process of acquiring a replacement for our oldest Clinac-21EX accelerator, which we have had for over 12 years. Room renovation is scheduled to begin February, 2014,, with accelerator installation scheduled for summer of that year. The new machine will be a state-of-the-art Varian TrueBeam. This accelerator will be equipped with the new high definition multi-leaf collimator with leaf widths as thin as 5 mm. This will render it capable of performing frameless stereotactic radiosurgery (SRS), although a set of circular collimators and an SRS planning module are included in the acquisition. This will replace our current Radionics SRS system, which has been discontinued by the manufacturer. An upgrade to this accelerator has already been requested. This upgrade, the Edge Extracranial SABR Package for Truebeam will permit the unit to deliver frameless stereotactic body radiation therapy (SBRT) using advanced motion management based on radiofrequency local positioning using implanted fiducial transponders and infrared cameras..

我们制定了常规动态调强放射治疗 (dIMRT)。这是最复杂的 IMRT 治疗，需要大量的治疗前验证以确保准确执行。这些治疗是使用我们的双 Clinac-21EX 加速器进行的。用于通过螺旋断层放射治疗提供治疗的 Hi-ART 系统（Tomotherapy Inc.）已安装、接受并目前正在治疗患者。该系统为ROB提供了尖端的治疗技术，以支持未来的临床试验。我们已经通过 Nucletron 高剂量率后装机 (HDR) 启动了一系列举措，使用小型高强度 192Ir 源进行间质和腔内近距离放射治疗。通过购买 3 个直径分别为 5 毫米、7.5 毫米和 10 毫米的新施源器，我们的放射外科能力得到了扩展。新型飞利浦 Brilliance 16 切片、大口径 CT 模拟器已获得治疗床控制升级。机载成像 (OBI) 已安装在较新的 Clinac-21EX 上。用于提供门控放射治疗的瓦里安 RPM 呼吸门控系统的最终组件已获得，我们正在等待交付。呼吸门控将通过补偿治疗期间的规则呼吸运动来提高靶向能力。我们购买了两台最先进的扫描水模型，一台用于 CT 和断层放射治疗，另一台用于一般加速器用途。这些将极大地促进年度质量保证和研究目的的数据采集。我们还获得了资金批准，用于用新设备更换最旧的直线加速器。我们正在购买最旧的 Clinac-21EX 加速器的替代品，该加速器已经使用了 12 年多。房间改造计划于 2014 年 2 月开始，加速器安装计划于当年夏季进行。新机器将是最先进的 Varian TrueBeam。该加速器将配备新型高清多叶准直器，叶宽薄至5毫米。尽管采购中包含一组圆形准直器和一个 SRS 规划模块，但这将使其能够执行无框架立体定向放射外科 (SRS)。这将取代我们当前的 Radionics SRS 系统，该系统已被制造商停产。已经有人请求升级该加速器。此次升级，用于 Truebeam 的 Edge Extracranial SABR 套件将允许该装置使用基于射频局部定位的先进运动管理（使用植入的基准应答器和红外摄像机）来提供无框架立体定向身体放射治疗 (SBRT)。