Gated Optical Detectors-Dose Guided Radiotherapy

门控光学探测器-剂量引导放射治疗

• 批准号: 10014391
• 负责人: Robert Miller
• 金额: $ 15.41万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10014391
• 关键词: Agreement; Caliber; Calibration; Cherenkov Radiation; Cone; Dependence; Detection; Development; Dose; Fiber; Generations; Goals; Human Resources; Individual; Laboratory Research; Legal patent; Length; Licensing; Measurement; Modeling; Optics; Output; Photons; Physiologic pulse; Radiation; Radiation therapy; Scanning; Signal Transduction; System; Technology; Technology Transfer; Vendor; Water; Work; base; detector; dosimetry; electron radiation; falls; in vivo; lightspeed; luminescence; new technology; off-patent; optical fiber; radiation response; response; signal processing; virtual

A new self-gated system with 4 detection channels and all signal processing has been delivered and performs to specifications, eliminating the problem of calibration stability. Calibration stability is now 1%. New fibers are being developed by NRL that will be more uniform in dose response and will be based on a 100 micron optical fiber rather than the current 400 micron model. The Naval Research Laboratory has withdrawn their support for this project. As an alternative, we have acquired a scintillation detector that compensates for Cerenkov radiation. This system (which was delivered in April, 2019) has a detector that has a 1mm diameter with a 1mm length. While not as small as the OSL detector, it should be adequate for accurate output measurements of a 4mm diameter stereotactic cone. The additional advantage of this detector is that it is compatible with our IBA Blue Phantom II scanning water phantom. Due to other pressing work, we expect to begin measurements in the Fall of 2019.

具有 4 个检测通道和所有信号处理功能的新型自选通系统已交付并按规格执行，消除了校准稳定性问题。校准稳定性现在为 1%。 NRL 正在开发新的光纤，其剂量响应将更加均匀，并且基于 100 微米光纤而不是当前的 400 微米模型。海军研究实验室已撤回对该项目的支持。作为替代方案，我们获得了一个闪烁探测器，可以补偿切伦科夫辐射。该系统（2019 年 4 月交付）的探测器直径为 1 毫米，长度为 1 毫米。虽然不像 OSL 探测器那么小，但它应该足以精确测量 4 毫米直径立体定向锥的输出。该探测器的另一个优点是它与我们的 IBA Blue Phantom II 扫描水体模兼容。由于还有其他紧迫的工作，我们预计将于 2019 年秋季开始测量。