Neurobiological impact of acute digital media abstinence among drug using college students

吸毒大学生急性数字媒体戒断的神经生物学影响

• 批准号: 10677380
• 负责人: Jessica Shannon Flannery
• 金额: $ 6.95万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10677380
• 关键词: Abstinence; Ache; Acute; Affective; Agreement; Anhedonia; Anxiety; Automobile Driving; Behavior; Brain; Cellular Phone; Cognitive; Computers; Corpus striatum structure; Cues; Data Collection; Dependence; Development; Devices; Drug Withdrawal Symptoms; Drug usage; Education; Family; Funding; Habenular Nucleus; Health; Hydrocortisone; Incentives; Individual; Individual Differences; Intervention; Life; Life Experience; Link; Measurement; Measures; Neurobiology; Neurocognitive; Neurosciences; Outcome; Participant; Peripheral; Personality Traits; Pharmaceutical Preparations; Physiological; Physiology; Population; Postdoctoral Fellow; Prevalence; Psychological reinforcement; Psychosocial Factor; Public Health; Punishment; Recording of previous events; Recovery; Reporting; Research; Resolution; Rewards; Risk; Risk Factors; Salivary; Severities; Sleeplessness; Social Reinforcement; Stimulus; Stream; Structure; Substance Addiction; Substance Use Disorder; Substance abuse problem; Symptoms; System; Techniques; Technology; Training; Withdrawal; Withdrawal Symptom; Work; addiction; adolescent brain development; age group; aged; associated symptom; brain based; clinical practice; college; common symptom; comorbidity; craving; cue reactivity; digital; digital media; drug craving; drug use behavior; drug withdrawal; dysphoria; experience; inattention; interest; neural; neuroimaging; non-drug; prevent; response; reward processing; social; social norm; substance use; substance user; tv watching; university student; wireless fidelity; young adult

PROJECT SUMMARY Addictive drug use is highly prevalent among college-aged young adults and is linked to the development of substance use disorders and other negative health outcomes later in life. Thus, understanding factors driving use is a critical public health concern. While prior work has linked use to psycho-social factors, increased reliance on technological devices (e.g., mobile phones, computers, gaming consoles), has introduced new risk-factors that cannot be ignored. As digital media delivers a consistent stream of rewarding stimuli, heavy use has the potential to dysregulate neurobiological, reward processing systems implicated in drug use, and result in withdrawal symptoms when prevented. Digital withdrawal symptoms may intensify digital media craving, and craving for other rewards (e.g., drugs), in turn, leading to an increased risk for addictive digital media and drug use. Identifying symptoms of maladaptive technology use that may predispose young adults to escalating drug use is critical. The main objective of the proposed project is to characterize individual differences in neurocognitive digital withdrawal symptoms and drug craving, following a period of digital media abstinence, and assess associations with digital and drug use behaviors. Brain function, and withdrawal symptomology among drug using young adults will be examined before and after a period of digital media abstinence in which participants will surrender their mobile phone over-night and agree to not engage in any screen-time. Specifically, alterations in reinforcement processing brain function and responsivity to drug and technology cues, following acute digital abstinence, will be characterized (Aim 1). Drug craving and digital withdrawal symptoms (physiological, affective, cognitive) linked to acute digital media abstinence will be examined (Aim2). Finally, relations between individual differences in substance and digital media use history, observed digital withdrawal symptoms, and altered brain function will be examined (Aim3). The proposed aims will expand the PI’s existing experience in addiction neuroscience by allowing her to study comorbid risk for addictive digital and substance use and gain new training in, peripheral physiology measurement, high-resolution neuroimaging, and subcortical segmentation techniques.

项目概要 药物成瘾在大学青年中非常普遍，并且与药物滥用的发展有关 因此，了解影响使用的因素对于公共卫生至关重要。 虽然之前的研究已将使用与心理社会因素联系起来，但对技术设备（例如移动设备）的依赖却增加了。 随着数字媒体的发展，数字媒体带来了新的不容忽视的风险因素。 持续不断的奖励刺激，大量使用可能会导致神经生物学和奖励处理失调 与药物使用有关的系统，并且在预防时可能会导致戒断症状。 加剧对数字媒体的渴望，以及对其他奖励（例如毒品）的渴望，进而导致上瘾的风险增加 识别可能使年轻人容易出现适应不良技术使用的症状。 拟议项目的主要目标是描述吸毒行为的个体差异。 戒断数字媒体一段时间后的神经认知数字戒断症状和药物渴望，并评估 与青少年吸毒者的数字和吸毒行为以及戒断症状的关联。 成年人将在数字媒体禁欲期之前和之后接受检查，在此期间将放弃他们的数字媒体 手机通宵并同意不从事任何屏幕时间具体修改加固处理。 急性数字戒断后，大脑功能以及对药物和技术线索的反应将被表征（目标 1) 与急性数字媒体相关的药物渴望和数字戒断症状（生理、情感、认知）。 最后，将检查物质的个体差异与数字媒体使用之间的关系。 将检查病史、观察到的数字戒断症状和大脑功能改变（目标 3）。 将允许 PI 研究成瘾的共病风险，从而扩展 PI 在成瘾神经科学方面的现有经验 数字和物质使用，并获得外周生理学测量、高分辨率神经成像和 皮层下分割技术。