Center for Mesoscale Mapping

中尺度测绘中心

基本信息

批准号：
10618982
负责人：
BRUCE R ROSEN
金额：
$ 125.96万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10618982
关键词：
3-Dimensional Acceleration Address Alzheimer&apos s Disease Anatomic Models Basic Science Biological Brain Brain Stem Cell Nucleus Cerebral Palsy Communities Computer Models Computer software Consensus Data Data Set Development Devices Diffusion Dimensions Disease Educational process of instructing Educational workshop Electroencephalography Electromagnetics Electrophysiology (science)Epilepsy Evaluation Event Fiber Frequencies Functional Magnetic Resonance Imaging Generations Goals Histologic Human Image Investigation Link Machine Learning Magnetic Resonance Imaging Maps Measures Mental Depression Mental disorders Microscopic Mind Modeling Molecular Morphologic artifacts Motion Multiple Sclerosis Neurons Neurosciences Performance Peripheral Nerve Stimulation Property Publications Research Personnel Resolution Resources Respiration Scanning Services Signal Transduction Sleep Disorders Slice Spatial Distribution Structure Surface System Techniques Technology Time Training Training Programs Transcranial magnetic stimulation Visualization Work brain magnetic resonance imaging cognitive neuroscience data space deep learning design electric field frontier human disease human imaging improved in vivo industry partner instrumentation machine learning algorithm meter model building nervous system disorder neural neuroimaging neuropathology novel open source post-doctoral training pre-doctoral reconstruction response spatiotemporal tool tool development translational neuroscience usability web based software white matter

项目摘要

Overview of the Proposed Resource – Abstract The goal of the Center for Mesoscale Mapping is to drive the convergence of microscopic- and macroscopic- scale evaluation of brain structure and function for human translational neuroscience, by developing and applying tools to study the spatial distribution and temporal orchestration of mesoscopic events in the human brain. Our Collaborators will, through a dynamic “push-pull” relationship, provide unique problems which drive the development of these tools, and in return guide us in the design and optimization of our toolbox for practical use in a variety of normal and disease settings. While there is still no formal consensus on the definition of mesoscopic within the neuroscience community, we take as our guide the spatial and temporal scales at which local groups of neurons act in coherent fashion – in the cortex, this includes the spatial scale of columns and laminar structures (between ~0.1-1 mm), while in deeper structures includes the myriad of deep brain and brainstem nuclei. Preliminary data from our own center, and of course others throughout the world, now support the notion that we are on the threshold of being able to map, measure and perturb the human brain at these scales, and do so comprehensively across wide swaths of the human brain. Temporally too, recent advances suggest a convergence between temporal scales addressable with tools like fMRI, which can now investigate delta frequency coherent phenomena, and advanced electromagnetic tools to measure and perturb coherent electrophysiological activity at higher frequencies still. With this convergence in mind, the tools we proposed to develop within the TRDs of the CMM will provide our Collaborative and Service User community with the important “missing links” between the advances in human cognitive neuroscience at the “system level,” and the enormous strides in cellular level circuit functional characterization. Our Collaborators will bring their own unique challenges to help us define and further refine these tools, offering problems requiring distinct measures of human brain structural and functional properties in a variety of normal and disease settings. Our Service Users will utilize our tools to better understand human neural systems, and particularly human disease states from multiple sclerosis to Alzheimer’s, to depression and epilepsy. Finally, our Center will seek to disseminate these tools, through open-source software and hardware designs, industrial partnerships and “hands-on” teaching courses for hardware, and to train a new generation of human neuroscientists in the use of our advanced tools to explore the human brain at this next frontier.

拟议资源概述 - 摘要中尺度测绘中心的目标是推动微观和宏观的融合通过开发和应用，对人类转化神经科学的大脑结构和功能进行规模评估研究人脑介观事件的空间分布和时间编排的工具。合作者将通过动态的“推拉”关系，提供独特的问题来推动开发这些工具，并指导我们设计和优化我们的工具箱以供实际使用虽然在各种正常和疾病环境中仍然没有就定义达成正式共识。在神经科学界的介观范围内，我们以空间和时间尺度为指导局部神经元组以连贯的方式起作用——在皮层中，这包括柱的空间尺度和层状结构（~0.1-1毫米之间），而更深的结构包括无数的深部大脑和来自我们自己的中心以及世界各地其他中心的初步数据现在支持这一点。我们即将能够在这些方面绘制、测量和扰动人类大脑规模，并在人类大脑的广泛领域进行全面的研究，这也是最近的进展。建议使用功能磁共振成像等工具可寻址的时间尺度之间的收敛，现在可以研究德尔塔频率相干现象，以及用于测量和扰乱相干的先进电磁工具考虑到这种融合，我们提出了更高频率的电生理活动。在 CMM 的 TRD 内开发将为我们的协作和服务用户社区提供人类认知神经科学在“系统层面”的进步与我们的合作者将在细胞级电路功能表征方面取得巨大进步。帮助我们定义和进一步完善这些工具的挑战，提出了需要采取不同措施的问题我们的服务用户在各种正常和疾病环境下的人脑结构和功能特性。将利用我们的工具更好地了解人类神经系统，特别是人类疾病状态最后，我们的中心将努力传播这些疾病。工具，通过开源软件和硬件设计、行业合作伙伴关系和“实践”教学硬件课程，并培训新一代人类神经科学家使用我们的先进工具探索人类大脑的下一个前沿领域。

项目成果

期刊论文数量（103）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

建议在大脑临床研究中实施定量磁化率图：ISMRM 电磁组织特性研究组的共识。

DOI：
发表时间：
2023-07-05
期刊：
影响因子：
0
作者：
QSM Consensus Organization Committee;Bilgic, Berkin;Costagli, Mauro;Chan, Kwok;Duyn, Jeff;Langkammer, Christian;Lee, Jongho;Li, Xu;Liu, Chunlei;Marques, José P;Milovic, Carlos;Robinson, Simon;Schweser, Ferdinand;Shmueli, Karin;Spincema
通讯作者：
Spincema

Personalized 7T fMRI-Guided navigation TMS targeting: Preliminary data of speech-motor cortex in speech perception.

个性化 7T fMRI 引导导航 TMS 定位：言语感知中言语运动皮层的初步数据。

DOI：
发表时间：
2023
期刊：
影响因子：
7.7
作者：
Daneshzand, Mohammad;Lankinen, Kaisu;Ahveninen, Jyrki;Wang, Qing Mei;Green, Jordan R;Kimberley, Teresa J;Li, Shasha
通讯作者：
Li, Shasha

A fast direct solver for surface-based whole-head modeling of transcranial magnetic stimulation.

用于基于表面的经颅磁刺激全头建模的快速直接求解器。

DOI：
发表时间：
2023-10-31
期刊：
影响因子：
4.6
作者：
Makaroff, S N;Qi, Z;Rachh, M;Wartman, W A;Weise, K;Noetscher, G M;Daneshzand, M;Deng, Zhi;Greengard, L;Nummenmaa, A R
通讯作者：
Nummenmaa, A R

The effect of meninges on the electric fields in TES and TMS. Numerical modeling with adaptive mesh refinement.

脑膜对 TES 和 TMS 电场的影响。