Extended Treatment for Smoking Cessation

延长戒烟治疗

基本信息

批准号：
8281698
负责人：
SEAN P. DAVID
金额：
$ 56.8万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8281698
关键词：
21 year old Abstinence Address Adolescent Adult Air Behavioral Bupropion Carbon Monoxide Cells Cellular Phone Chronic Clinical Trials Cocaine Dependence Cognitive Cognitive Therapy Computers Controlled Study Counseling County Cox Proportional Hazards Models Detection Development Disease Drug Addiction Early Diagnosis Eligibility Determination Event History Analysis Intention Knowledge Logistic Regressions Maintenance Measures Mediator of activation protein Modeling Monitor Nicotine Opiate Addiction Outcome Outcome Measure Participant Pharmacotherapy Phase Population Study Prevalence Probability Public Health Randomized Recommendation Relapse Reporting Research Sampling Selection Bias Smoke Smoker Smoking Societies Supportive care Survival Analysis Tail Target Populations Techniques Technology Telephone Time Tobacco Treatment Failure Withholding Treatment Work Writing alcoholism therapy base cigarette smoking craving depressive symptoms design disorder later incidence prevention experience follow-up meetings nicotine patch open label primary outcome public health relevance rapid detection response secondary outcome self help skills training smoking cessation success treatment planning treatment response varenicline

项目摘要

DESCRIPTION (provided by applicant): Research indicates that drug addictions are chronic, relapsing disorders requiring extended therapy and follow-up. However, only a few smoking cessation trials have examined the utility of extended therapy models. We propose to examine the efficacy of a multi-component extended cigarette smoking cessation treatment in promoting longer-term smoking abstinence. Adult smokers and adolescent smokers (18 - 21) years of age will serve as the target population for this study. A total of 400 smokers will be randomized. Treatment will include both open label and extended treatment phases. Open Label Treatment. All 400 smokers will receive nicotine patch (21mg), bupropion (300mg) and individualized cognitive and behavioral skills training (ST). Nicotine patches and bupropion will be provided for 10 weeks and cognitive behavior therapy (CBT) will be provided for 26 weeks. Those who fail to respond to bupropion and nicotine patch will be switched to varenicline through week 26. Those who relapse beyond week 10 will re-start bupropion and nicotine patch through week 26. Extended Treatment. Following open label treatment, half (n=200) will receive CBT from week 26 - week 52. CBT will include both therapist-directed and self-directed relapse prevention skills training. In addition, telephone counseling will be provided in conjunction with voicemail, computer and cell phone technology enabling monitoring of treatment plan implementation and early detection of smoking "slips" and rapid response by treatment staff. Control. Remaining participants (n=200) will receive monthly telephone support calls from week 26 - week 52. The proposed study will address several important gaps in our knowledge of effective smoking cessation treatment. First, this will be one of only a handful of studies to investigate the effects of extended therapy for smoking cessation. Second, this will be among the first controlled studies to examine the effects of a multi-component treatment employing pharmacotherapy, intensive behavioral skills training, self-help skills training and rapid slip detection and response via voicemail, cell phone and telephone counseling. PUBLIC HEALTH RELEVANCE: Cigarette smoking is a major public health problem. This study is designed to study the efficacy of an extended smoking cessation treatment.

描述（由申请人提供）：研究表明，药物成瘾是慢性的，需要扩展治疗和随访的疾病。但是，只有少量的戒烟试验检查了扩展治疗模型的实用性。我们建议检查多组分扩展吸烟戒烟治疗在促进长期戒烟方面的功效。成年吸烟者和青少年吸烟者（18-21岁）将成为这项研究的目标人群。共有400名吸烟者将被随机分配。治疗将包括开放标签和扩展治疗阶段。开放标签处理。所有400名吸烟者都将接受尼古丁补丁（21mg），安非他酮（300mg）和个性化的认知和行为技能培训（ST）。将提供10周的尼古丁斑块和安非他酮，并将提供认知行为疗法（CBT）26周。那些未能对安非他酮和尼古丁补丁做出反应的人将在第26周之前切换到Varenicline。第10周以后复发的人将在第26周期间重新启动安非他酮和尼古丁补丁。在开放标签处理后，一半（n = 200）将从第26周 - 第52周开始接受CBT。CBT将包括治疗师指导和自我指导的预防复发技能培训。此外，将与语音邮件，计算机和手机技术一起提供电话咨询，从而可以监测治疗计划实施和早期检测吸烟“滑动”以及治疗人员的快速反应。控制。剩余的参与者（n = 200）将从第26周至第52周的每月电话支持电话。拟议的研究将解决我们有关有效戒烟治疗的知识中的几个重要差距。首先，这将是研究扩展治疗对戒烟的影响的少数研究之一。其次，这将是最早检查使用药物治疗，强化行为技能培训，自助技能培训以及通过语音邮件，手机和电话咨询的快速滑移检测和响应的多组分治疗效果的对照研究之一。公共卫生相关性：吸烟是一个主要的公共卫生问题。这项研究旨在研究扩展戒烟治疗的功效。