PHYSIOLOGY OF CALCIUM APPETITE

钙食欲的生理学

• 批准号: 2146039
• 负责人: MICHAEL G TORDOFF
• 金额: $ 12.6万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2146039
• 关键词: 1,25 dihydroxycholecalciferol; appetite; calcitonin; calcium metabolism; dietary calcium; hormone regulation /control mechanism; laboratory rat; nutrition related tag; parathyroid hormones; physiologic bone resorption; satiations

The role of calcium in mammalian physiology is one of the most active areas of current biomedical research, with over 7,500 papers a year published on the subject. Despite the wealth of information concerning the control of calcium metabolism, scant attention has been paid to the role of calcium intake in calcium homeostasis. There are several clear demonstrations that manipulations of calcium metabolism influence the motivation to drink calcium but there has been no concerted attempt to study the physiological substrate of this behavior. The absence of these data is a critical omission in light of the low intake of calcium by most Americans, and the involvement of calcium in many chronic diseases (e.g. osteoporosis, kidney disease, heart disease, hypertension). The studies proposed here are designed to elucidate the physiological processes underlying the motivation to drink calcium. The questions addressed include (1) "Which aspects of calcium metabolism initiate calcium appetite?" To answer this question, calcium metabolism will be manipulated by (a) depriving rats of dietary calcium, and (b) administering calcium-regulatory hormones. The effect of these treatments on calcium intake and calcium metabolism will be compared. Measures will be taken of calcium intake, calcium balance, blood concentrations of calcium, parathyroid hormone (PTH), calcitonin, and I ,25-dihydroxyvitamin D, bone reabsorption, and tissue calcium content. The goal will be to determine which of these facets of calcium metabolism is responsible for the control of calcium appetite. The second question addressed is (2) "How does ingested calcium satiate calcium appetite?". Studies designed to answer this will (a) relate changes in calcium physiology to the satiation of calcium appetite, and (b) localize the organs involved. These studies will provide a solid foundation for understanding the physiological controls of calcium intake, and the role of calcium intake in calcium homeostasis. This information will help identify the reasons for the low intake of calcium by Americans, and provide strategies to help rectify this problem.

钙在哺乳动物生理学中的作用是最活跃的 当前的生物医学研究领域，每年有7,500篇论文 发表在该主题上。尽管有很多关于 控制钙代谢，对该角色的关注很少 钙稳态中的钙摄入量。有几个清晰 证明了钙代谢的操纵影响 喝钙的动机，但没有一致的尝试 研究这种行为的生理底物。缺乏这些 鉴于大多数钙的摄入量低，数据​​是一个严重的省略 美国人，以及钙参与许多慢性疾病（例如 骨质疏松症，肾脏疾病，心脏病，高血压）。 此处提出的研究旨在阐明生理 饮用钙动机的基础的过程。 问题 解决的问题包括（1）“钙代谢的哪些方面开始 钙食欲？”回答这个问题，钙代谢将是 由（a）剥夺大鼠饮食钙的操纵，（b） 给予钙调节激素。这些治疗的影响 将比较钙摄入量和钙代谢。措施将 从钙摄入量，钙平衡，血液浓度中服用 钙，甲状旁腺激素（PTH），降钙素和I，25-二羟基维生素 D，骨吸附和组织钙含量。目标是 确定钙代谢的哪个方面负责 钙食欲的控制。解决的第二个问题是（2）“如何 摄入钙的钙食欲吗？”。 回答这将（a）将钙生理的变化与饱腹 钙食欲，（b）定位所涉及的器官。 这些研究将为理解 钙摄入的生理控制和钙摄入的作用 在钙稳态中。此信息将有助于确定原因 为了低于美国人的钙摄入量，并提供了帮助的策略 纠正这个问题。