NEURAL CONTROL OF CALCIUM INTAKE

钙摄入量的神经控制

• 批准号: 6516941
• 负责人: STUART A MCCAUGHEY
• 金额: $ 0.95万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6516941
• 关键词: 1,25 dihydroxycholecalciferol; appetite; behavior test; brain regulatory center; calcitonin; calcium ion; chorda tympani; cranial nerves; dietary calcium; experimental brain lesion; gene expression; immature animal; immunocytochemistry; laboratory rat; male; neuroregulation; nutrient intake activity; nutrition related tag; parathyroidectomy; peripheral nervous system; protooncogene; telencephalon

Many Americans consume low amounts of calcium, which places them at risk for several major diseases. However, little is known about the factors that control calcium ingestion. The goal of the proposed research is to investigate which peripheral nerves and brain areas control calcium intake in rats. Ultimately, this may help to provide insight into why animals, including humans, select certain levels of calcium in their diets and how this behavior might be altered to prevent disease. Three experiments will be conducted, with specific aims as follows: 1) to determine whether particular brain areas are more active when calcium appetite is induced, using immunocytochemistry to detect c-Fos, c-Jun, and FosB; 2) to determine whether lesions of the subfornical organ affect calcium intake; 3) to determine whether transection of the chorda tympani and/or glossopharyngeal nerve affects short-term intake of CaCl2 and other solutions.

许多美国人消耗的钙含量低，这使他们有多种主要疾病的风险。但是，对控制钙摄入的因素知之甚少。拟议的研究的目的是研究哪些周围神经和大脑区域控制大鼠的钙摄入量。最终，这可能有助于洞悉为什么包括人类在内的动物在饮食中选择某些水平的钙以及如何改变这种行为以预防疾病。将进行三个实验，具有以下特定目的：1）确定特定的大脑区域在诱导钙食欲时是否更活跃，使用免疫细胞化学检测C-FOS，C-JUN和FOSB； 2）确定亚长质器官的病变是否影响钙的摄入； 3）确定Chorda Tympani和/或胃咽部神经的横断是否会影响CaCl2和其他溶液的短期摄入。