PHYSIOLOGY OF CALCIUM APPETITE

钙食欲的生理学

• 批准号: 6176243
• 负责人: MICHAEL G TORDOFF
• 金额: $ 22.16万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6176243
• 关键词: 1,25 dihydroxycholecalciferol; appetite; calcitonin; calcium metabolism; dietary calcium; hormone regulation /control mechanism; laboratory rat; nutrition related tag; parathyroid hormones; satiations

DESCRIPTION (Adapted From The Applicant's Abstract): This is the second revision of a competitive renewal seeking 4 years of support for a program aimed at identifying the physiological basis of a specific calcium appetite. Scant attention has been paid to the role of calcium intake and calcium homeostasis. This is a critical omission in light of the low calcium intake of most Americans, and the involvement of low calcium intake in many chronic diseases (e.g., osteoporosis, kidney disease, heart disease, and hypertension). In this project, it is proposed to take advantage of the biopsychological methods developed to study other ingestive behaviors to elucidate the physiological processes underlying the motivation to drink calcium. Three specific aims are proposed. First, the hypothesis will be tested that circulating concentrations of calcium mediate calcium intake. This will be done by measuring calcium intake in rats given intracerebral ventricular infusions of calcium or calcium antagonists. Second, the hypothesis will be tested that one or more of the calcium regulatory hormones has direct effects on calcium intake. The contribution of each of the three hormones involved (parathyroid hormone, calcitonin, and 1,25-dihydroxy vitamin D) will be assessed by measuring the effect on calcium intake of 1,25-dihydroxy vitamin D infused into rats with plasma concentration of parathyroid hormone and calcitonin held constant. Third, the question of why calcium deprived rats drink sodium chloride and various other taste solutions will be addressed. It is hypothesized that calcium deprived rats ingest these solutions because they increase plasma calcium concentrations, which in turn, reinforces subsequent intake. This will be tested by a) screening a large number of compounds to determine whether they influence plasma calcium concentrations and b) using the electronic esophagus preparation to investigate whether rats find manipulations that increase plasma calcium rewarding. These studies will provide a solid foundation for understanding the physiological controls of calcium intake. This information from studies with rats will help identify the reasons for the low calcium intake of Americans, and provide strategies to help rectify this problem.

描述（根据申请人的摘要改编）： 这是寻求4年支持的竞争性更新的第二次修订 旨在确定特定的生理基础的计划 钙食欲。注意钙摄入的作用很少 和钙稳态。鉴于低点，这是一个严重的遗漏 大多数美国人的钙摄入量以及低钙摄入量的参与 许多慢性疾病（例如骨质疏松症，肾脏疾病，心脏病和 高血压）。在这个项目中，建议利用 开发了用于研究其他摄入行为的生物心理学方法 阐明喝酒动机的生理过程 钙。提出了三个具体目标。首先，该假设将进行检验 钙的循环浓度介导钙摄入量。这将是 通过测量脑室心室的大鼠的钙摄入量来完成 钙或钙拮抗剂的输注。其次，假设将是 测试了一种或多种钙调节激素具有直接影响 在钙摄入量。涉及的三种激素中每种贡献的贡献 （甲状旁腺激素，降钙素和1,25-二羟基维生素D） 通过测量对1,25-二羟基维生素D的钙摄入的影响评估 注入甲状旁腺激素的血浆浓度和 降钙素保持恒定。第三，为什么钙剥夺大鼠的问题 将解决氯化钠和其他各种味觉溶液。它 假设钙剥夺了大鼠摄入这些溶液，因为它们 增加血浆钙浓度，进而增强后续 进气。这将通过a）筛选大量化合物来测试 确定它们是否影响血浆钙浓度，b）使用 电子食管准备，以研究大鼠是否发现操纵 这增加了血浆钙的奖励。这些研究将提供坚实的 理解钙摄入量的生理控制的基础。这 与大鼠研究的信息将有助于确定较低的原因 美国人的钙摄入量，并提供策略来纠正这一点 问题。