Development of Mechanisms Underlying Human Motor Learning

人类运动学习机制的发展

• 批准号: 10618802
• 负责人: Amy J. Bastian
• 金额: $ 68.67万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2029-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618802
• 关键词: Affect; Age; Brain; Child; Childhood; Cognitive; Complex; Data; Dependence; Development; Disease; Education; Environment; Gender; Home; Human; Injury; Laboratories; Learning; Lesion; Methods; Motor; Movement; Nervous System Trauma; Neurologic; Neurosciences; Persons; Process; Resolution; Rewards; Signal Transduction; Testing; Therapeutic; Time; Training; Video Games; Well in self; experience; motor learning; social; success; timeline

Movement abilities affect a child’s physical, social and emotional well-being, as well as their educational success—all of which can last a lifetime. Movement is fundamental to the development of abilities across domains (motor, cognitive), because it underlies a child’s ability to explore and interact with the environment and other people. How children learn movement is a complex process that changes with development, experience and injury. It depends on a suite of interacting brain mechanisms that are driven by different signals (e.g. reward, error), have different learning rates, retention capacities, contextual dependencies and vulnerabilities to neurological damage. A key gap in human neuroscience is our limited understanding of this complex interplay. We propose to leverage recently developed home-based experimental tasks and new laboratory methods to generate high resolution time courses for different components of childhood motor learning, and then determine how they are affected by neurological lesions. With these data we can create a detailed flowchart of movement learning capacity and the effects of disease, as a function of age and developmental markers. This would provide the comprehensive understanding required to generate tailored therapeutic training strategies targeted to age, developmental maturity, gender, and disease state.

运动能力影响孩子的身体、社交和情感健康，以及他们的教育 成功——所有这些都可以持续一生。运动是能力发展的基础。 领域（运动、认知），因为它是孩子探索环境和与环境互动的能力的基础 孩子们如何学习运动是一个复杂的过程，会随着发展、经验而变化。 它取决于一系列由不同信号驱动的相互作用的大脑机制（例如奖励， 错误），具有不同的学习率、保留能力、上下文依赖性和漏洞 人类神经科学的一个关键差距是我们对这种复杂相互作用的理解有限。 我们建议利用最近开发的家庭实验任务和新的实验室方法 为儿童运动学习的不同组成部分生成高分辨率时间课程，然后确定 利用这些数据，我们可以创建详细的运动流程图。 学习能力和疾病的影响，作为年龄和发育标记的函数。 制定针对年龄的定制治疗培训策略所需的全面理解， 发育成熟度、性别和疾病状态。