Project 1 - Vaping Behavior, the Emergence of Dependence, and Well-being

项目 1 - 电子烟行为、依赖性的出现和幸福感

• 批准号: 10628251
• 负责人: ERIC Christian DONNY
• 金额: $ 23.29万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628251
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Articulation; Attention; Behavior; Behavioral; Biological Markers; Characteristics; Cognitive; Data; Dependence; Development; Devices; Dimensions; Disease; Dose; Emotional; Environmental Risk Factor; Frequencies; Functional disorder; Goals; Happiness; Health; High School Student; Individual; Interview; Knowledge; Life; Link; Literature; Longitudinal Surveys; Longitudinal cohort; Marijuana; Measures; Mediating; Mediator; Mental disorders; Methods; Modernization; Natural History; Neurobiology; Nicotine; Nicotine Dependence; Participant; Personal Satisfaction; Prevention; Psyche structure; Recording of previous events; Reporting; Respiratory physiology; Risk; Risk Assessment; Role; Sampling; Social Well-Being; Students; Surveys; Symptoms; System; Time; Tobacco; Tobacco use; World Health Organization; Youth; addiction; adolescent health; cognitive testing; cohort; critical period; daily functioning; design; electronic cigarette use; emotion regulation; experience; handicapping condition; health communication; high school; improved; multidisciplinary; novel; preference; prevent; prospective; psychologic; recruit; skills; social; vaper; vaping

ABSTRACT – PROJECT 1: Vaping Behavior, the Emergence of Dependence, and Well-being Since 2014, vaping has been the most popular form of tobacco use among high school students, with over 1.7 million reporting current use in 2021. Recent evidence also indicates an increase in the proportion of adolescents who vape 20 or more days a month, highlighting a surge in the levels of use often associated with dependence. Understanding vaping behavior, including frequency and intensity of use, during the critical years of high school, and the relationship with dependence is central to vaping prevention. Prevention also relies on knowledge of the health effects of vaping that are relevant to adolescents. One such effect is dependence, a recognized psychiatric disease with an associated pathophysiology that can impact adolescent life. However, the potential health impact of vaping extends beyond dependence. Modern definitions conceptualize health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity” (World Health Organization). Adolescent well-being involves a number of characteristics (e.g., perseverance, connectedness) that depend on fundamental skills (cognitive, emotional, social) acquired during this critical period of development. A large literature demonstrates how functioning within these domains is vulnerable to the impact of nicotine, suggesting that vaping, particularly when associated with dependence, is likely to impact adolescent well-being. The overall goal of Project 1 is to characterize how vaping leads to dependence and impacts the well-being of adolescents. The Specific Aims are: 1) Prospectively assess vaping behavior and the emergence of symptoms of vaping dependence during adolescence; 2) Describe how vaping is related to well- being; and 3) Leverage a mixed methods approach to improve survey measures and deepen understanding of how changes in vaping, dependence, health and well-being impact adolescent daily life. To address these aims, Project 1 will screen over 13,500 high school students (all grades) to recruit a sample of vaping and non- vaping students to participate in an online survey. The initial survey will be conducted in over 4300 students from all grades (cross-sectional). Freshmen, Sophomores and Juniors who are recruited into the online survey will form a longitudinal cohort of over 3100 students with additional waves of surveys conducted every six months. A subset (N=360; 240 vapers) of the longitudinal cohort will complete lab-based assessments at two time points, 18 months apart (i.e., corresponding to Waves 1-3 and 4-6). Finally, up to 40 participants will complete in-depth interviews after Wave 1 and up to 40 participants will complete interviews after Wave 4-6. Project 1 will provide a rich characterization of the natural history of vaping and the impact it has on adolescent development and well-being. This information is central to the overarching goal of Project MARVEL – to prevent youth vaping through empirically-based and adolescent relevant health communications.

摘要 – 项目 1：电子烟行为、依赖性的出现和幸福感 自 2014 年以来，电子烟一直是高中生中最流行的烟草使用形式，超过 1.7 到 2021 年，报告当前使用情况的人数将达到 100 万。最近的证据还表明， 每月吸电子烟 20 天或以上的青少年，这突显了电子烟使用量的激增，这通常与以下因素相关： 了解关键年份的电子烟行为，包括使用频率和强度。 高中阶段，与依赖的关系是预防电子烟的核心。 了解与青少年相关的电子烟对健康的影响之一就是依赖性。 公认的精神疾病及其相关的病理生理学可能会影响青少年的生活。 现代定义将健康概念化为电子烟对健康的潜在影响。 “一种身体、心理和社会适应的完整状态，而不仅仅是没有疾病或虚弱” （世界卫生组织）。青少年的福祉涉及许多特征（例如毅力、 连通性）取决于在此关键时期获得的基本技能（认知、情感、社交） 大量文献表明这些领域的功能如何容易受到影响。 尼古丁的影响，表明电子烟，特别是与依赖相关时，可能会影响 项目 1 的总体目标是描述电子烟如何导致依赖和影响。 影响青少年的福祉 具体目标是： 1) 前瞻性评估电子烟行为和 青春期出现电子烟依赖症状；2) 描述电子烟与健康有何关系； 3) 利用混合方法改进调查措施并加深对 电子烟、依赖性、健康和福祉的变化如何影响青少年的日常生活。 目标是，项目 1 将筛选超过 13,500 名高中生（所有年级），以招募电子烟和非电子烟样本。 电子烟学生参与在线调查 初步调查将在 4300 多名学生中进行。 来自所有年级（横截面）的新生、二年级学生和三年级学生。 将形成一个由 3100 多名学生组成的纵向队列，每六次进行一次额外的调查 纵向队列的一个子集（N=360；240 名电子烟使用者）将在两个月后完成基于实验室的评估。 时间点，相隔 18 个月（即对应第 1-3 波和第 4-6 波） 最后，最多 40 名参与者。 第 1 波后将完成深度访谈，第 4-6 波后将有最多 40 名参与者完成访谈。 项目 1 将提供电子烟自然历史及其对青少年影响的丰富特征 这些信息是 MARVEL 项目总体目标的核心—— 通过基于经验的和青少年相关的健康传播来预防青少年吸电子烟。