MARVEL: A Multidisciplinary Assessment of Risks from Vaping during Early Life

MARVEL：对生命早期电子烟风险的多学科评估

• 批准号: 10628250
• 负责人: ERIC Christian DONNY
• 金额: $ 185.69万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628250
• 关键词: Address; Adolescence; Adolescent; Adolescent Development; Affect; Behavior; Biological; Biological Markers; Biostatistics Core; Brain; Cluster randomized trial; Cognitive; Collaborations; Data Collection; Dependence; Development; Ensure; Environmental Risk Factor; Epidemic; Epigenetic Process; Evaluation; Face; Genetic; Genomics; Health; High School Student; Individual; Intervention; Interview; Life; Literature; Modification; Molecular; Neurocognitive; Nicotine; Oxidative Stress; Pathway interactions; Pattern; Personal Satisfaction; Physiological; Prevention; Puberty; Regulation; Reporting; Research; Research Support; Risk Assessment; Risk Behaviors; Schools; Structure; Surveys; Symptoms; System; Teenagers; Testing; Time; Tobacco; Tobacco use; Youth; addiction; adolescent health; airway inflammation; cerebrovascular; cognitive development; cognitive skill; community partnership; critical developmental period; design; developmental psychology; experience; health assessment; health communication; high school; human subject protection; improved; interdisciplinary approach; multidisciplinary; neurodevelopment; nicotine use; novel; operation; oxidative damage; peer; prevent; programs; prospective; psychologic; psychosocial; psychosocial development; pulmonary function; recruit; respiratory health; skills; stem; systemic inflammatory response; tobacco regulatory science; vaping

ABSTRACT – OVERALL The proposed program project, A Multidisciplinary Assessment of Risks of Vaping in Early Life (Project MARVEL), takes an integrated approach to assessing vaping behavior and the emergence of dependence; elucidating the impact of vaping on adolescent health; and generating empirically-tested messages to reduce adolescent vaping. In 2020, 19.6% of high school students, representing over 3 million adolescents, reported past month vaping. Moreover, the proportion of high school students who report frequent vaping has increased substantially. Significant gaps exist in understanding current patterns of youth vaping, the relationship between vaping and dependence, the impact of vaping on health, and how best to stem the surge in adolescent vaping. The overarching aims of this program project are to: (1) Assess the use of nicotine-containing vaping products and the relationship between vaping and the emergence of symptoms of dependence, including individual, interpersonal, and environmental factors that may moderate the impact of vaping; (2) Determine how vaping disrupts health and well-being through its impact on key physiological and psychological systems that are still developing during adolescence; and (3) Evaluate the potential impact of vaping prevention messages, developed based on emerging evidence of health harms from Project MARVEL and focused on the ways in which vaping affects adolescents’ bodies and lives. Four projects are proposed, supported by four cores. Project 1 will assess the relationship between vaping and the emergence of dependence, describe how vaping impacts the development of adolescent well-being, and determine how adolescents perceive the impact of vaping on their daily lives. Project 2 will examine the association between vaping, neurodevelopment, autonomic regulation, and cognitive/psychological skills. Project 3 will determine how vaping impacts respiratory health by examining symptoms, function, and early molecular alterations in airways. Project 4 will develop, optimize, and evaluate messages about novel health harms of vaping, identified in Projects 1-3 and the extant literature, that resonate with high school students. The Administrative Core will manage operations for Project MARVEL, facilitate interactions between projects, and coordinate study participation. The Biostatistics Core will ensure our designs and analyses maximize validity, generalizability, and efficiency. The Adolescent Research Support Core will address the unique challenges of conducting research with a large number of adolescents from multiple schools, facilitate recruitment and retention, ensure protection of human subjects, and maintain and leverage community partnerships. Finally, the Biomarker and Product Evaluation Core will characterize the most commonly used products and provide objective markers of exposure and biological effect. Project MARVEL has the potential to greatly improve our understanding of how vaping impacts adolescent health and how best to intervene to reduce vaping during this critical developmental period.

摘要 – 总体 拟议的计划项目，对早期电子烟风险的多学科评估（项目 MARVEL），采用综合方法来评估电子烟行为和依赖性的出现； 阐明电子烟对青少年健康的影响；并生成经过实证检验的信息以减少 2020 年，19.6% 的高中生（代表超过 300 万青少年）报告了青少年吸电子烟的情况。 此外，报告经常吸电子烟的高中生比例有所增加。 在理解当前青少年电子烟的模式以及两者之间的关系方面存在重大差距。 电子烟和依赖性、电子烟对健康的影响，以及如何最好地遏制青少年电子烟激增。 该计划项目的总体目标是： (1) 评估含尼古丁电子烟产品的使用情况 以及电子烟与依赖症状出现之间的关系，包括个人、 (2) 确定如何抽吸 通过影响仍然存在的关键生理和心理系统来破坏健康和福祉 (3) 评估电子烟预防信息的潜在影响， 基于 MARVEL 项目中新出现的健康危害证据而开发，重点关注 电子烟影响青少年的身体和生活提出了四个项目，并得到四个核心的支持。 项目 1 将评估电子烟与依赖性的出现之间的关系，描述电子烟如何 影响青少年福祉的发展，并确定青少年如何看待青少年的影响 项目 2 将研究电子烟与神经发育、 自主调节和认知/心理技能项目 3 将决定电子烟的影响。 项目 4 将通过检查呼吸道的症状、功能和早期分子变化来监测呼吸道健康。 开发、优化和评估有关项目 1-3 中确定的电子烟对健康的新危害的信息，以及 与高中生产生共鸣的现有文献 行政核心将管理运营。 对于 Project MARVEL，促进项目之间的互动并协调研究参与。 生物统计学核心将确保我们的设计和分析最大限度地提高有效性、普遍性和效率。 青少年研究支持核心将解决大规模开展研究的独特挑战 来自多所学校的青少年数量，促进招募和保留，确保保护人类 最后，生物标志物和产品评估。 核心将描述最常用产品的特征，并提供客观的暴露标记和 MARVEL 项目有可能极大地提高我们对电子烟如何产生的理解。 影响青少年健康以及如何最好地干预以减少这一关键发育时期的电子烟。