Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescents

儿童和青少年执行功能、食欲调节和肥胖的神经发育

• 批准号: 10643633
• 负责人: Shana Adise
• 金额: $ 14.99万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643633
• 关键词: 6 year old; Abdomen; Address; Adolescence; Adolescent; Adolescent obesity; Affect; Age; Appetite Regulation; Attenuated; Award; Behavioral; Biological Markers; Birth; Body Composition; Body fat; Bottle feeding; Brain; Brain region; Cattle; Child; Child Development; Child Health; Childhood; Complex; Data; Data Analyses; Data Set; Decision Making; Desire for food; Development; Development Plans; Diabetes Mellitus; Diet; Dietary Sugars; Endocrinology; Environment; Exposure to; Faculty; Feeding behaviors; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Grain; Grant; Growth; Health; Hospitals; Human Milk; Hyperphagia; Infant; Intake; Intervention Studies; Laboratories; Latino; Life; Link; Los Angeles; Machine Learning; Magnetic Resonance Imaging; Measures; Mediating; Mentored Research Scientist Development Award; Mentors; Mentorship; Metabolism; Milk; Modeling; Mothers; National Institute of Diabetes and Digestive and Kidney Diseases; Neighborhoods; Neuroanatomy; Neurocognitive; Neurologic; Obesity; Outcome; Pediatric Hospitals; Pediatric Research; Performance; Phenotype; Population; Postdoctoral Fellow; Prefrontal Cortex; Process; Protocols documentation; Puberty; Publications; Research; Research Personnel; Research Support; Resources; Rewards; Scientist; Short-Term Memory; Site; Solid; Source; Statistical Data Interpretation; Structure; Theoretical model; Thinness; Time; Training; United States National Institutes of Health; Variant; Ventral Striatum; Weight; Weight Gain; Youth; career; career development; cognitive development; cognitive neuroscience; cohort; computational neuroscience; critical developmental period; critical period; early-life nutrition; eating in absence of hunger; economic disparity; environmental disparity; executive function; experience; healthy weight; high body mass index; infant nutrition; innovation; insight; neurodevelopment; neuroimaging; neuroinflammation; novel; nutrition; obesity development; obesity in children; obesity risk; pediatric department; population based; programs; prospective; recruit; sex; skills; social disparities; social influence; statistics; sugar; tool; treatment program

Dr. Adise is an excellent and ideal candidate for an NIDDK Mentored Research Scientist Development Award. She is currently transitioning from a postdoctoral fellow on the NIH-funded Adolescent Brain Cognitive Development (ABCD) study to faculty in the Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism at Children’s Hospital of Los Angeles (CHLA). She has a strong publication and funding record and a unique combination of expertise across cognitive and computational neuroscience, nutrition, obesity, and pediatric ingestive behavior. The proposed research plan has three specific aims: 1) To characterize the temporal and directional cause vs. consequence relationship between neuroanatomical and functional associations of executive function and obesity development throughout adolescence; 2) To determine if developmental trajectories of executive function differ among populations with fewer neighborhood/ environmental resources linked to optimal child health and development. 3) To examine the contribution of infant nutrition to the development of executive function and appetite regulation during childhood. Dr. Adise has proposed an innovative study to address these aims that employs magnetic resonance imaging (MRI), novel statistical analyses (e.g., latent growth curve modeling, machine learning) and behavioral and biological markers of appetite regulation. The career development plan supports the research aims and Dr. Adise’s transition to independence with training in 1) neurocognitive development with respect to sex- and pubertal-specific influence on brain maturation; 2) social and environmental disparities (SED) and health; 3) Infant nutrition, appetite regulation, and body composition; and 4) Novel tools longitudinal data analysis. Her co-primary mentors, Drs. Elizabeth Sowell and Michael Goran are leading experts in the fields of neuroimaging, SED research, and infant nutrition and appetite regulation, respectively. Dr. Adise will also receive additional training with Dr. Kyung Rhee, a leading expert in translational mechanisms of executive functioning training in intervention research, and Dr. Joshua Millstein, an expert in longitudinal data analysis. CHLA is among the top 5 pediatric research hospitals in the USA and the population base consists of children who face extreme SEDs and health outcomes, including high rates of pediatric obesity. As one of Dr. Adise’s goals is to understand the influence of social and environmental disparities on obesity outcomes, CHLA is the perfect environment for Dr. Adise to accomplish her short- and long-term training and career goals. Dr. Adise has full backing and commitment from The Department of Pediatrics, which will continue to provide her with protected research time, a start-up package with significant funds, office and research space, and access to a wide array of research cores, including the MRI core as well as access to intramural funding programs. This award will help to establish the foundation on which Dr. Adise will build her expertise as a leading scientist in the field of neurocognitive development of pediatric ingestive behavior by providing the protected time to achieve the necessary training, experience, and mentorship.

Adise 博士是 NIDDK 指导研究科学家发展奖的优秀且理想的候选人。 她目前正从 NIH 资助的青少年大脑认知项目的博士后研究员转型 针对儿科、内分泌科、糖尿病科和糖尿病科的教员进行的发展（ABCD）研究 她在洛杉矶儿童医院 (CHLA) 的新陈代谢方面拥有良好的发表和资助记录。 认知和计算神经科学、营养学、肥胖症和 拟议的研究计划有三个具体目标：1）描述时间特征。 以及神经解剖学和功能关联之间的方向原因与结果关系 整个青春期的执行功能和肥胖发展；2) 确定是否发育； 社区/环境资源较少的人群的执行功能轨迹有所不同 3) 研究婴儿营养对儿童健康和发育的贡献。 阿迪斯博士提出了儿童时期执行功能和食欲调节的发展。 为解决这些目标而进行的创新研究采用磁共振成像（MRI）、新颖的统计方法 分析（例如，潜在生长曲线建模、机器学习）以及行为和生物标记 职业发展计划支持阿迪斯博士的研究目标和过渡。 通过以下方面的培训获得独立性：1）关于性别和青春期特异性影响的神经认知发展 大脑成熟；2）社会和环境差异（SED）和健康；3）婴儿营养、食欲 调节和身体成分；以及4）新工具纵向数据分析。 Elizabeth Sowell 和 Michael Goran 是神经影像学、SED 研究和婴儿领域的顶尖专家 Adise 博士还将分别接受 Kyung Rhee 博士的额外培训。 干预研究中执行功能训练转化机制的领先专家，博士。 Joshua Millstein 是一位纵向数据分析专家，CHLA 是排名前 5 的儿科研究医院之一。 在美国，人口基数由面临极端 SED 和健康结果的儿童组成，包括 阿迪斯博士的目标之一是了解社会和儿童肥胖率的影响。 由于环境差异对肥胖结果的影响，CHLA 是阿迪斯博士实现她目标的完美环境 Adise 博士的短期和长期培训和职业目标得到了该部门的全力支持和承诺。 儿科，这将继续为她提供受保护的研究时间，这是一个具有重大意义的启动计划 资金、办公和研究空间，以及使用各种研究核心的机会，包括 MRI 核心 作为获得校内资助计划的机会，该奖项将有助于为阿迪斯博士奠定基础。 将培养她作为儿科消化神经认知发展领域领先科学家的专业知识 通过提供受保护的时间来获得必要的培训、经验和指导来行为。