UCSF Musculoskeletal Training Program

加州大学旧金山分校肌肉骨骼训练计划

• 批准号: 10625232
• 负责人: Tamara N Alliston
• 金额: $ 24.26万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625232
• 关键词: Musculoskeletal; Training Programs

PROJECT SUMMARY The overall goal of the UCSF Musculoskeletal (MSK) Training Program is to prepare Ph.D. scientists and M.D. or M.D./Ph.D. residents and fellows for a lifetime of scholarly pursuits that lead to in-depth understanding and improved care for patients with MSK diseases. We are confident that our proposed training program will accomplish this goal. Drawing on the solid mentorship skills of 35 nationally renowned and highly collaborative faculty with primary appointments in 10 academic and clinical departments, the UCSF MSK Training Program provides rigorous research training in basic and clinical/translational sciences important to the study of MSK diseases. These 35 participating faculty members bring multi-disciplined expertise that reflects areas of rapidly expanding research development such as stem cells, neurobiology, tissue regeneration, molecular physiology, and artificial intelligence. A vital aspect of the program is to focus exclusively on preparing postdoctoral trainees for independent research careers. The program proposes three slots for postdoctoral trainees, including two slots for Ph.D. postdoctoral fellows (research training duration of two years) and one slot for physician trainees from our research-track residency program in Orthopaedic Surgery (research training duration of one year). The central component of the training experience is direct research in the basic laboratory or clinical/translational research group of a primary research mentor. The training experience fuses this scientific training with sustained, individualized, and goal-oriented mentorship that guides trainees along the pathway to gaining their competitive research funding. The program includes formal coursework in ethics, rigor and reproducibility, statistical analysis, and grant-writing. It will also emphasize basic and clinical/translational science education by drawing on significant curricular activities designed explicitly for MSK science; innovative research experiences with an emphasis on scientific rigor and translation; individualized development plans that utilize evidence-based approaches for career planning; numerous exposures to state-of-the-art methods and techniques through weekly grand rounds and invited lectures, monthly research-in-progress seminars, journal clubs, and an annual retreat; and scientific communication through formal expectations of publications and presentations at national meetings. These activities capitalize on the programmatic and scientific infrastructure created by several existing MSK- related centers and institutes with UCSF-wide participation and influence. Overall, the training enabled by this program will attract and prepare junior scientists with the goal of understanding the mechanistic basis of MSK diseases, finding new therapies for these diseases, and ensuring that scientific discoveries lead to advances in public health in an equitable and cost-effective manner. In doing so, the program will ensure that a cadre of young scientists will pursue academic careers in MSK research and advance the field in fundamental ways.

项目概要 UCSF 肌肉骨骼 (MSK) 培训计划的总体目标是培养博士学位。科学家和医学博士 或医学博士/博士居民和研究员一生的学术追求，导致深入的理解和 改善对 MSK 疾病患者的护理。我们相信我们提出的培训计划将 实现这个目标。借鉴 35 名全国知名且高度协作的人的扎实指导技能 UCSF MSK 培训计划的 10 个学术和临床部门的主要任命教师 提供对 MSK 研究很重要的基础科学和临床/转化科学方面严格的研究培训 疾病。这 35 名参与的教师带来了多学科的专业知识，反映了快速发展的领域 扩大干细胞、神经生物学、组织再生、分子生理学等研究发展， 和人工智能。该计划的一个重要方面是专注于培养博士后学员 为独立研究事业。该计划为博士后培训生提供了三个名额，其中包括两个 博士名额博士后研究员（研究培训期限为两年）和​​实习医生名额 来自我们的骨科住院医师研究项目（研究培训为期一年）。这 培训经验的核心组成部分是在基础实验室或临床/转化中的直接研究 研究小组的主要研究导师。培训经验将科学培训与持续、 个性化、以目标为导向的指导，指导学员走上获得竞争力的道路 研究经费。该计划包括道德、严谨性和可重复性、统计分析、 和拨款写作。它还将通过借鉴基础科学和临床/转化科学教育来强调 专门为 MSK 斯隆科学领域设计的重要课程活动；创新研究经验 强调科学严谨性和翻译；利用基于证据的个性化发展计划 职业规划的方法；每周多次接触最先进的方法和技术 大型查房和邀请讲座、每月正在进行的研究研讨会、期刊俱乐部和年度静修会； 通过对国家会议上的出版物和演示的正式期望进行科学交流。 这些活动利用了由 MSK 现有的多个项目创建的计划和科学基础设施 具有 UCSF 广泛参与和影响力的相关中心和机构。总体而言，由此实现的培训 该计划将吸引和培养初级科学家，以了解 MSK 的机制基础 疾病，寻找这些疾病的新疗法，并确保科学发现带来进步 以公平和具有成本效益的方式保障公共卫生。在此过程中，该计划将确保一支骨干队伍 年轻科学家将在 MSK 斯隆研究领域追求学术生涯，并从根本上推动该领​​域的发展。