AAOS/ORS Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research Symposium

AAOS/ORS 通过了解软骨与骨之间的串扰来应对关节疾病研究研讨会

基本信息

项目摘要

 DESCRIPTION (provided by applicant): The healthy joint seamlessly integrates the mechanical and biological functions of multiple tissues, including cartilage, bone, synovium, nerve, vasculature, and others, to support smooth, pain-free movement. Surprisingly little is known about the mechanisms that support this integration, or the mechanisms that disrupt it in joint disease. Understanding these mechanisms is central to maintaining joint health and treating joint disease, the leading cause of disability in the United States. Joint diseases such a osteoarthritis, osteonecrosis, juvenile arthritis, and post-traumatic arthritis disable individuals across the lifespan affecting over 46 million Americans, including more than half of the population over 65. While advances in the study of individual joint tissues have shed light on the mechanisms of joint disease, more research is needed to elucidate the mechanisms by which these tissues interact, and the local and systemic factors responsible for this crosstalk. Therefore, the American Academy of Orthopaedic Surgeons (AAOS) selected Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone as the topic for the 2016 AAOS Research Symposium. The exceptional burden of joint disease motivates a focused, interdisciplinary symposium designed to advance the development of better clinical solutions. This symposium takes an innovative approach to overcome the boundaries in disciplinary or scientific expertise that limit progress in understanding the integration of individual tissues in he joint. The primary objective of the symposium is to engage clinicians, engineers, and biologists to share emerging concepts from each discipline on crosstalk among bone, cartilage, systemic factors, and other tissues in joint health and disease across the lifespan. The structure of the meeting supports this goal, with a single-platform format that allows the entire group to consider together and discuss seven topics that were selected to highlight advances from individual fields within the context of joint crosstalk. All sessions at this 2.5-day meeting feature invited presentations by scientific leaders and pioneering junior investigators who are applying new ideas and approaches to understand joint function. Each session includes a 30 minute structured discussion to identify the leading edge of the field, determine gaps in knowledge, and establish new research priorities. Fifteen New Investigator Awards support the engagement of diverse early stage investigators as oral or poster presenters. In addition to publishing the proceedings of the symposium, outcomes include workshops at annual meetings of musculoskeletal research societies, a webinar, and inclusion of updated research priorities in the AAOS Unified Orthopaedic Research Agenda, which communicates musculoskeletal research needs to funding agencies, Congress, and the public. Given the urgent demand for improved clinical solutions, and the recent advances in bone and cartilage research, this symposium will stimulate the dialogue to accelerate research on crosstalk among tissues in the joint, to understand and ultimately treat degenerative joint disease.
 描述(由申请人提供):健康的关节无缝地整合了多种组织的机械和生物功能,包括软骨、骨、滑膜、神经、脉管系统等,以支持平滑、无痛的运动,但令人惊讶的是,人们对这种关节知之甚少。支持这种整合的机制,或在关节疾病中破坏这种机制的机制对于维持关节健康和治疗关节疾病至关重要,关节疾病是美国骨关节炎等关节疾病的主要原因。骨坏死、幼年关节炎和创伤后关节炎使个体丧失能力 影响超过 4600 万美国人的整个生命周期,其中包括超过一半的 65 岁以上人口。虽然个体关节组织研究的进展已经揭示了关节疾病的机制,但还需要更多的研究来阐明这些组织发生疾病的机制。因此,美国骨科医师学会 (AAOS) 选择通过了解软骨和骨之间的串扰来应对关节疾病作为本次会议的主题。 2016 AAOS 研究研讨会。关节疾病的特殊负担激发了一场重点突出的跨学科研讨会,旨在推动更好的临床解决方案的开发。该研讨会采用创新方法来克服限制理解整合进展的学科或科学专业知识的界限。研讨会的主要目标是让信徒、工程师和生物学家分享各个学科关于骨、软骨、系统因素和其他组织在关节健康和疾病中的串扰的新兴概念。会议的结构支持这一目标,采用单一平台的形式,使整个小组能够共同考虑和讨论七个主题,这些主题是为了在联合讨论的背景下突出各个领域的进展而选择的。为期 2.5 天的会议邀请科学领袖和初级研究人员进行演讲,他们应用新的想法和方法来理解联合功能。每次会议包括 30 分钟的结构化讨论,以确定该领域的前沿、确定知识差距并建立联系。十五个新的研究重点。新研究者奖支持不同的早期研究人员作为口头或海报展示者的参与,除了出版研讨会论文集外,成果还包括肌肉骨骼研究协会年会的研讨会、网络研讨会以及将最新的研究重点纳入 AAOS。鉴于对改进临床解决方案的迫切需求以及骨骼和软骨研究的最新进展,统一骨科研究议程向资助机构、国会和公众传达了肌肉骨骼研究的需求。该研讨会将促进对话,加速关节组织间串扰的研究,了解并最终治疗退行性关节疾病。

项目成果

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Tamara N Alliston其他文献

Tamara N Alliston的其他文献

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{{ truncateString('Tamara N Alliston', 18)}}的其他基金

Osteocyte-dependent mechanisms of bone cartilage crosstalk in osteoarthritis
骨关节炎中骨软骨串扰的骨细胞依赖性机制
  • 批准号:
    10727267
  • 财政年份:
    2023
  • 资助金额:
    $ 1.5万
  • 项目类别:
UCSF Musculoskeletal Training Program
加州大学旧金山分校肌肉骨骼训练计划
  • 批准号:
    10625232
  • 财政年份:
    2023
  • 资助金额:
    $ 1.5万
  • 项目类别:
The mechanistic control of bone quality and joint crosstalk by osteocytes
骨细胞对骨质量和关节串扰的机械控制
  • 批准号:
    10605074
  • 财政年份:
    2022
  • 资助金额:
    $ 1.5万
  • 项目类别:
Core Center for Musculoskeletal Biology and Medicine (Overall Application)
肌肉骨骼生物学与医学核心中心(整体应用)
  • 批准号:
    10460468
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Skeletal Biology and Biomechanics (SBB) Core
骨骼生物学和生物力学 (SBB) 核心
  • 批准号:
    10460472
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Skeletal Biology and Biomechanics (SBB) Core
骨骼生物学和生物力学 (SBB) 核心
  • 批准号:
    10642797
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Core Center for Musculoskeletal Biology and Medicine (Overall Application)
肌肉骨骼生物学与医学核心中心(整体应用)
  • 批准号:
    10707598
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Skeletal Biology and Biomechanics (SBB) Core
骨骼生物学和生物力学 (SBB) 核心
  • 批准号:
    10215391
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Core Center for Musculoskeletal Biology and Medicine (Overall Application)
肌肉骨骼生物学与医学核心中心(整体应用)
  • 批准号:
    10642787
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:
Core Center for Musculoskeletal Biology and Medicine (Overall Application)
肌肉骨骼生物学与医学核心中心(整体应用)
  • 批准号:
    10215386
  • 财政年份:
    2019
  • 资助金额:
    $ 1.5万
  • 项目类别:

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