Core Center for Musculoskeletal Biology and Medicine (Overall Application)

肌肉骨骼生物学与医学核心中心（整体应用）

基本信息

批准号：
10215386
负责人：
Tamara N Alliston
金额：
$ 77.42万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10215386
关键词：
Acids Animal Model Applications Grants Archives Area Back Basic Science Biology Biomechanics Biometry Calcium-Sensing Receptors Clinical Clinical Data Clinical Sciences Collaborations Communication Country Custom Degenerative polyarthritis Diagnosis Digital Libraries Discipline Disease Educational Curriculum Endocrine Epidemiology Etiology Experimental Designs Fostering Fracture Functional disorder Funding Goals Grant Health Histologic Human Image Infrastructure Insulin-Like Growth Factor I Investigation Knowledge Laboratories Leadership Locomotion Manuscripts Medical center Medicine Metabolic Bone Diseases Methods Mission Musculoskeletal Musculoskeletal Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases Orthopedic Surgery Orthopedics Osteoporosis PTH gene Patients Productivity Protocols documentation Publishing Reagent Recording of previous events Reporting Reproducibility Research Research Design Research Personnel Research Support Resources Role Science Scientist Services Site Specialist Supervision System Technology Tissue Sample Tissues Training Transcend Translating Translational Research United States National Institutes of Health Visit base bench to bedside disease phenotype experience imaging modality innovation interdisciplinary collaboration longitudinal database mechanical load member men musculoskeletal imaging non-invasive imaging osteoporosis with pathological fracture pre-clinical programs quantitative imaging reconstruction skeletal symposium synergism theories tool

项目摘要

The proposed UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) will be an interdisciplinary consortium of 114 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in musculoskeletal science. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology and Biomechanics Core; 2) Imaging Core; and 3) Epidemiology, Biostatistics and Study Design Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External and Internal Advisory and Boards, and a symposium with a rotating topic relevant to our theme of Systems in Musculoskeletal Biology and Medicine. Another vital component of the Center is its Pilot/Feasibility grant program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology grant program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

拟议的 UCSF 肌肉骨骼生物学和医学核心中心 (CCMBM) 将是一个由 114 名基础和临床科学家组成的跨学科联盟，致力于了解生物学和肌肉骨骼疾病的病理生理学。目标是刺激和支持跨学科加州大学旧金山分校现有的主要研究项目之间的合作，以加速转化肌肉骨骼科学研究。实验室到临床转化研究的一个基本挑战是需要在人类中验证小动物模型的发现。拟议的 CCMBM 将克服这个问题通过在研究疾病生物学的研究人员和开发先进技术的专家之间建立联系来克服障碍研究工具和方法、分析大量临床数据的科学家以及积极救治患者。 UCSF CCMBM 提出了三个核心：1）骨骼生物学和生物力学核心； 2）成像核心； 3) 流行病学、生物统计学和研究设计核心。这些核心将提供研究支持和技术培训，以及新合作的场所和新成员的切入点。该中心还将通过浓缩计划促进科学交流；课程包括研讨会以当地和访问科学家为特色，每年一次全天的静修，包括外部和内部咨询和董事会和研讨会，其轮流主题与我们的肌肉骨骼生物学系统主题相关药品。该中心的另一个重要组成部分是其试点/可行性资助计划。这提供了种子资金初级研究人员和刚接触肌肉骨骼研究的科学家。最后，工具和技术补助金计划将为中心成员提供资金，以利用杰出的专业研究 UCSF 的 CCMBM 之外提供的服务。总体而言，CCMBM 的资金基础雄厚，支持加州大学旧金山分校的实力很强，中心内外互动的机会很多。对象该中心的目标是充分利用所有可用资源来促进基础生物学的发现肌肉骨骼疾病。