Core Center for Musculoskeletal Biology and Medicine (Overall Application)

肌肉骨骼生物学与医学核心中心（整体应用）

• 批准号: 10642787
• 负责人: Tamara N Alliston
• 金额: $ 77.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10642787
• 关键词: Acceleration; Acids; Animal Model; Applications Grants; Archives; Area; Back; Basic Science; Biology; Biomechanics; Biometry; Calcium-Sensing Receptors; Clinical; Clinical Data; Clinical Sciences; Collaborations; Communication; Country; Dedications; Degenerative polyarthritis; Diagnosis; Digital Libraries; Discipline; Disease; Education; Educational Curriculum; Endocrine; Epidemiology; Etiology; Experimental Designs; Fostering; Fracture; Functional disorder; Funding; Goals; Grant; Health; Histologic; Human; Image; Infrastructure; Insulin-Like Growth Factor I; Investigation; Knowledge; Laboratories; Leadership; Locomotion; Manuscripts; Medical center; Medicine; Metabolic Bone Diseases; Methods; Mission; Musculoskeletal; Musculoskeletal Diseases; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Orthopedic Surgery; Orthopedics; Osteoporosis; PTH gene; Patients; Productivity; Protocols documentation; Publishing; Reagent; Recording of previous events; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Support; Resources; Role; Rotation; Science; Scientist; Services; Site; Specialist; System; Technology; Tissue Sample; Tissues; Training; Transcend; Translating; Translational Research; United States National Institutes of Health; Visit; base; bench-to-bedside translation; biomechanical test; disease phenotype; experience; imaging modality; innovation; interdisciplinary collaboration; longitudinal database; mechanical load; member; men; musculoskeletal imaging; non-invasive imaging; osteoporosis with pathological fracture; pre-clinical; programs; quantitative imaging; reconstruction; skeletal; symposium; synergism; theories; tool

The proposed UCSF Core Center for Musculoskeletal Biology and Medicine (CCMBM) will be an interdisciplinary consortium of 114 basic and clinical scientists dedicated to understanding the biology and pathophysiology of musculoskeletal disease. The goal is to stimulate and support transdisciplinary collaborations amongst existing, premier research programs at UCSF in order to accelerate translational research in musculoskeletal science. A fundamental challenge for bench-to-bedside translational research is the need to validate in humans the findings from small animal models. The proposed CCMBM will overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. The UCSF CCMBM proposes three cores: 1) Skeletal Biology and Biomechanics Core; 2) Imaging Core; and 3) Epidemiology, Biostatistics and Study Design Core. These cores will provide research support and technical training, as well as a venue for new collaborations and an entry point for new members. The Center will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External and Internal Advisory and Boards, and a symposium with a rotating topic relevant to our theme of Systems in Musculoskeletal Biology and Medicine. Another vital component of the Center is its Pilot/Feasibility grant program. This provides seed money to junior investigators and to scientists new to musculoskeletal research. Finally, the Tool and Technology grant program will provide funds to Center members for the purpose of utilizing the outstanding specialized research services available outside the CCMBM at UCSF. Overall, the funding base for the CCMBM is robust, support from UCSF is strong, and opportunities for interactions within and outside the Center are numerous. The object of the Center is to make optimum use of all available resources to catalyze discovery in the basic biology of musculoskeletal disease.

拟议的 UCSF 肌肉骨骼生物学和医学核心中心 (CCMBM) 将是一个 由 114 名基础和临床科学家组成的跨学科联盟，致力于了解生物学和 肌肉骨骼疾病的病理生理学。目标是刺激和支持跨学科 加州大学旧金山分校现有的主要研究项目之间的合作，以加速转化 肌肉骨骼科学研究。实验室到临床转化研究的一个基本挑战是 需要在人类中验证小动物模型的发现。拟议的 CCMBM 将克服这个问题 通过在研究疾病生物学的研究人员和开发先进技术的专家之间建立联系来克服障碍 研究工具和方法、分析大量临床数据的科学家以及 积极救治患者。 UCSF CCMBM 提出了三个核心：1）骨骼生物学和生物力学核心； 2）成像核心； 3) 流行病学、生物统计学和研究设计核心。这些核心将提供研究 支持和技术培训，以及新合作的场所和新成员的切入点。 该中心还将通过浓缩计划促进科学交流；课程包括研讨会 以当地和访问科学家为特色，每年一次全天的静修，包括外部和内部咨询和 董事会和研讨会，其轮流主题与我们的肌肉骨骼生物学系统主题相关 药品。该中心的另一个重要组成部分是其试点/可行性资助计划。这提供了种子资金 初级研究人员和刚接触肌肉骨骼研究的科学家。最后，工具和技术补助金 计划将为中心成员提供资金，以利用杰出的专业研究 UCSF 的 CCMBM 之外提供的服务。总体而言，CCMBM 的资金基础雄厚，支持 加州大学旧金山分校的实力很强，中心内外互动的机会很多。对象 该中心的目标是充分利用所有可用资源来促进基础生物学的发现 肌肉骨骼疾病。

项目成果

Predictors of a change in patient willingness to have Total knee arthroplasty: Insights from the osteoarthritis initiative.

患者全膝关节置换术意愿变化的预测因素：来自骨关节炎倡议的见解。

• 发表时间: 2020-06
• 作者: Bendich, Ilya;Halvorson, Ryan T;Ward, Derek;Nevitt, Michael
• 通讯作者: Nevitt, Michael

A comparison of alendronate to varying magnitude PEMF in mitigating bone loss and altering bone remodeling in skeletally mature osteoporotic rats.

阿仑膦酸钠与不同强度的脉冲电磁场​​在减轻骨骼成熟骨质疏松大鼠骨质流失和改变骨重塑方面的比较。

• DOI: 10.1016/j.bone.2020.115761
• 发表时间: 2020-11-17
• 期刊: Bone
• 影响因子: 4.1
• 作者: C. Androjna;Cristal S. Yee;Carter R. White;E. Waldorff;J. Ryaby;M. Zborowski;T. Alliston;R. Midura
• 通讯作者: R. Midura

Longitudinal Relationship Between Physical Activity and Joint Space Narrowing: Forty-Eight-Month Follow-Up Data From the Osteoarthritis Initiative.

体力活动与关节间隙狭窄之间的纵向关系：来自骨关节炎倡议的四十八个月随访数据。

• 发表时间: 2022-07
• 影响因子: 4.7
• 作者: Hu, Bo;Han, DongBai;Nevitt, Michael C;Wise, Barton L;Segal, Neil A
• 通讯作者: Segal, Neil A

The Prevalence of Bullying Among Pediatric Orthopaedic Patients.

儿科骨科患者中欺凌行为的发生率。

• 发表时间: 2021-09-01
• 作者: Carrillo, Laura A;Sabatini, Coleen S;Brar, Ravinder K;Jagodzinski, Jason E;Sabharwal, Sanjeev;Delgado, Eliana;Livingston, Kristin S
• 通讯作者: Livingston, Kristin S

MRI-Based Quantitative Osteoporosis Imaging at the Spine and Femur.

基于 MRI 的脊柱和股骨定量骨质疏松症成像。

• 发表时间: 2021
• 作者: Sollmann, Nico;Löffler, Maximilian T;Kronthaler, Sophia;Böhm, Christof;Dieckmeyer, Michael;Ruschke, Stefan;Kirschke, Jan S;Carballido;Karampinos, Dimitrios C;Krug, Roland;Baum, Thomas
• 通讯作者: Baum, Thomas