Spatial Organization of Temperature-Related Circadian and Vasomotor Rhythms

与温度相关的昼夜节律和血管舒缩节律的空间组织

• 批准号: 9361521
• 负责人: Alexander Gorbach
• 金额: $ 13.29万
• 依托单位: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9361521
• 关键词: Beds; Biological Markers; Biophysical Process; Blood flow; Body Temperature; Circadian Rhythms; Clinical; Clinical Research; Consumption; Goals; Guidelines; Hospitals; Immobilization; Maps; Measurement; Mechanics; Monitor; Morphologic artifacts; Motion; Periodicity; Peripheral; Phase; Physiological; Procedures; Skin; Staging; Surface; System; Techniques; Technology; Temperature; Theoretical model; Time; Validation; Variant; Vasomotor; Wireless Technology; Work; circadian pacemaker; design; endothelial dysfunction; human subject; image guided; operation; research study; sensor; tumor

Continuous monitoring of variations in blood flow is vital in assessing the status of microvascular and macrovascular beds for a wide range of clinical and research scenarios. Although a variety of techniques exist, most require complete immobilization of the subject, thereby limiting their utility to hospital or clinical settings. Those that can be rendered in wearable formats suffer from limited accuracy, motion artifacts, and other shortcomings that follow from an inability to achieve intimate, noninvasive mechanical linkage of sensors with the surface of the skin. We introduce an ultrathin, soft, skin-conforming sensor technology that offers advanced capabilities in continuous and precise blood flow mapping. Systematic work establishes a set of experimental procedures and theoretical models for quantitative measurements and guidelines in design and operation. Experimental studies on human subjects, including validation with measurements performed using state-of-the-art clinical techniques, demonstrate sensitive and accurate assessment of both macrovascular and microvascular flow under a range of physiological conditions. Refined operational modes eliminate long-term drifts and reduce power consumption, thereby providing steps toward the use of this technology for continuous monitoring during daily activities.

连续监测血流变化对于评估微血管和大血管床的状态至关重要，对于广泛的临床和研究情景。尽管存在各种技术，但大多数人都需要对该受试者进行完全固定，从而将其效用限制在医院或临床环境中。那些可以以可穿戴格式渲染的人的精度，运动伪像以及其他缺点，这些缺点从无法实现传感器与皮肤表面的亲密无创机械连接。我们引入了超薄，柔软，构成皮肤的传感器技术，可在连续和精确的血流图中提供高级功能。系统的工作建立了一组实验程序和理论模型，用于定量测量和设计和操作指南。关于人类受试者的实验研究，包括使用最先进的临床技术进行的测量验证，在一系列生理条件下对大血管和微血管流的敏感和准确评估。精致的操作模式消除了长期漂移并减少功耗，从而为使用该技术提供了在日常活动中进行连续监控的步骤。