Design of Infrared Imaging to Assess Vascular Tone in Peripheral Vascular Beds

评估外周血管床血管张力的红外成像设计

• 批准号: 8340636
• 负责人: Alexander Gorbach
• 金额: $ 3.83万
• 依托单位: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8340636
• 关键词: Adherence; Algorithms; Area; Atherosclerosis; Blood Vessels; Blood flow; Cutaneous; Development; Disease; Dorsal; Endothelium; Fingers; Forearm; Frequencies; Genes; Globin; Hemoglobin; Human; Image; Individual; Inflammatory; Injury; Lesion; Leukocytes; Measurement; Mediating; Microcirculation; Nucleotides; Peripheral; Phase; Physiologic pulse; Relative (related person); Reperfusion Therapy; Sickle Cell; Sickle Cell Anemia; Signal Transduction; Skin; Smooth Muscle; Spatial Distribution; Surface; System; Temperature; Testing; Time; Tissues; Ultrasonography; Veins; arterial tonometry; base; brachial artery; clinical application; design; image processing; in vivo; indexing; reactive hyperemia; vascular bed; vascular endothelial dysfunction; vasomotion

We demonstrate that functional infrared imaging is capable of detecting low frequency temperature fluctuations in intact human skin and revealing spatial, temporal, spectral, and time-frequency based differences among three tissue classes: microvasculature, large sub-cutaneous veins, and the remaining surrounding tissue of the forearm. We found that large veins have stronger contractility in the range of 0.005-0.06 Hz compared to the other two tissue classes. Wavelet phase coherence and power spectrum correlation analysis show that microvasculature and skin areas without vessels visible by IR have high phase coherence in the lowest three frequency ranges (0.005-0.0095 Hz, 0.0095-0.02 Hz, and 0.02-0.06 Hz), whereas large veins oscillate independently.

我们证明，功能性红外成像能够检测到完整的人体皮肤中的低频温度波动，并揭示了三个组织类别之间的空间，时间，光谱和基于时频的差异：微血管脉络膜，大脉管静脉，大型粉状静脉，以及前臂的其余周围组织。我们发现，与其他两个组织类别相比，大静脉在0.005-0.06 Hz范围内具有更强的收缩力。小波相相一致性和功率相关性分析表明，IR可见的微瘤和皮肤区域具有高相位相干性，最低三个频率范围（0.005-0.0095 Hz，0.0095-0.0.02 Hz，0.02-0.02 Hz，0.02-0.06 Hz，而0.02-0.06 Hz），而不是静脉内的大型静脉固有。