Public Engagement for Gene Drive Technology

基因驱动技术的公众参与

• 批准号: 10265521
• 负责人: Cinnamon S Bloss
• 金额: $ 45.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265521
• 关键词: Address; Affect; Agreement; Area; Catalogs; Communities; Complex; Coupled; Culicidae; Data; Dengue; Development; Disease; Disease Vectors; Documentation; Educational workshop; Effectiveness; Emerging Technologies; Ensure; Environment; Ethics; Foundations; General Population; Genes; Genetic; Genetic Engineering; Geographic Locations; Geography; Glean; Goals; Individual; Infection; Insecticide Resistance; Interdisciplinary Study; International; Intervention; Interview; Leadership; Link; Malaria; Methods; Modification; Mosquito Control; Organism; Persons; Process; Public Health; Publishing; Research; Research Personnel; Research Project Grants; Risk; Safety; Sampling; Series; Site; Social Policies; Structure; Surveys; Target Populations; Technology; Translations; Vector-transmitted infectious disease; Work; ZIKA; base; climate change; design; evidence base; field study; gene drive system; improved; innovation; insight; member; mosquito-borne; multidisciplinary; new technology; novel; novel strategies; product development; response; social; success; tool; vector; vector control

PROJECT SUMMARY Development of gene drives to control mosquito vectors of disease has rapidly accelerated in recent years, and these efforts may soon culminate in gene drive systems ready for open field testing. The success of gene drive and other novel vector control approaches will depend on design decisions, oversight, and plans for field testing and deployment that meet the needs of various stakeholders, including residents of affected areas and the general public, but there is little agreement about how best to obtain informed public input. In a recent analysis of engagement initiatives for novel vector control approaches, our group found that for many initiatives, there was a lack of documentation, and for initiatives that were documented, many had vaguely articulated goals that were not clearly linked to either the methods used or the stage of technological development. The goal of this study is to develop a robust conceptual framework for public engagement to guide the development of gene drives and other emerging technologies from early proof of concept through field trials to deployment. The framework we produce will be generalizable to other novel and exceptional technologies. Each aim of the proposed project is supported by prior published work conducted by our group and observations from preliminary data. In Specific Aim 1, we will conduct a systematic landscape analysis of engagement initiatives for existing novel genetic and other vector control technologies, including gene drive. In Specific Aim 2, we will formulate a public engagement framework that aligns stage of product development with engagement timing, methods, messages, and goals. In Specific Aim 3, we will obtain informed expert and public input on the engagement framework and use the input to refine and finalize the framework. This contribution will be significant because it will provide the foundation for a coherent and comprehensive approach to public engagement for gene drive and other novel and emerging technologies, thereby ensuring the successful translation of novel innovations to address critical public health problems. The approach is innovative in engaging both experts and a demographically and geographically diverse sample of members of the public, including both English and Spanish speakers. The work is feasible in our hands because our team of established investigators has a track record of successful multidisciplinary research projects related to public engagement for novel vector control interventions, as well as expertise in ethical, social, and policy issues related to gene drive.

项目概要 近年来，用于控制疾病蚊媒的基因驱动的开发迅速加速 多年以来，这些努力可能很快就会在基因驱动系统中达到顶峰，为露天测试做好准备。的成功 基因驱动和其他新颖的病媒控制方法将取决于设计决策、监督和计划 现场测试和部署，满足包括受影响地区居民在内的各个利益相关者的需求 和公众，但对于如何最好地获得知情的公众意见，几乎没有达成一致。在最近的一次 通过对新型病媒控制方法的参与举措进行分析，我们的小组发现对于许多举措来说， 缺乏文件记录，对于已记录的举措，许多举措的目标表述模糊 与所使用的方法或技术发展阶段没有明确的联系。目标是 这项研究旨在为公众参与制定一个强有力的概念框架，以指导发展 基因驱动和其他新兴技术从早期概念验证到现场试验 部署。我们生成的框架将可推广到其他新颖且卓越的技术。 拟议项目的每个目标均得到我们小组先前发表的工作和观察的支持 从初步数据来看。在具体目标 1 中，我们将对参与度进行系统的景观分析 现有新型遗传和其他病媒控制技术（包括基因驱动）的举措。特定目标 2、我们将制定一个公众参与框架，将产品开发阶段与参与相结合 时间、方法、信息和目标。在具体目标 3 中，我们将获得有关专家和公众的知情意见 参与框架并使用输入来完善和最终确定该框架。这一贡献将是巨大的 因为它将为公众参与的连贯和全面的方法奠定基础 基因驱动和其他新兴技术，从而确保小说的成功翻译 解决关键公共卫生问题的创新。该方法具有创新性，让专家和 人口统计和地理上不同的公众样本，包括英国人和 讲西班牙语的人。这项工作在我们手中是可行的，因为我们的资深调查人员团队有一个轨道 与公众参与新型病媒控制相关的成功多学科研究项目的记录 干预措施，以及与基因驱动相关的伦理、社会和政策问题的专业知识。