Changing lives, changing brains: How modern family and work life influences ADRD risks

改变生活，改变大脑：现代家庭和工作生活如何影响 ADRD 风险

基本信息

批准号：
10256738
负责人：
YAAKOV STERN
金额：
$ 63.87万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10256738
关键词：
Address Adult Affect Age Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Behavioral Biocompatible Materials Birth Brain Buffers Cessation of life Characteristics Child Cicatrix Cities Clinical Code Cognition Cognitive Cognitive aging Complex Consent Country Data Data Set Dementia Diagnosis Disease Economic Factors Economics Education Elderly Employment Environment Event Family Fertility Frequencies Genetic Predisposition to Disease Genetic Risk Health Health behavior Heterogeneity Hormonal Hour Impaired cognition Incidence Individual Intervention Investigation Joints Leisures Length Life Life Cycle Stages Link Marital Status Marriage Mediating Medical Modernization Natural experiment Norway Occupations Outcome Participant Pathway interactions Pattern Plants Population Population Study Prevalence Prevention Prospective Studies Public Health Recording of previous events Registries Research Resources Retirement Risk Risk Factors Sampling Sleep Sorting - Cell Movement Stress Surveys Tweens Unemployment Variant Woman Work age related aged base biobank child bearing cognitive development cognitive testing cohort data registry dementia risk effective therapy emerging adult family structure follow-up health economics improved longitudinal analysis men polygenic risk score prospective sex social social disadvantage socioeconomics spelling

项目摘要

The prevalence of Alzheimer's disease and related dementias (ADRD) is projected to triple by 2050. Currently, there is no known effective treatment for ADRD. Prevention through behavioral changes affecting ADRD risk is therefore of utmost importance, and about 35% of ADRD risk is thought to be attributable to potentially modifiable factors. Current changes in modern family life and work are likely to have important effects on the risk of ADRD, as the work and family structure multiple aspects of individuals lives and environments that are likely to be related to ADRD risks. Yet, work and family trajectories as pathways and moderators of ADRD risk are understudied. Our overall hypothesis is that contemporary changes in family patterns and work lives contribute to age related changes in cognition and ADRD. A shift to “modern” family structures and work tasks have occurred relatively early in Norway, and unique data availability allows these changes to be studied prospectively to predict coming changes in ADRD in the US and other countries. We will study life-course effects of and interactions between family and work in adulthood for risk of ADRD and cognitive impairment in older adults. This will be done by exploiting the exceptional Norwegian HUNT (Nord-Trondelag Health Study) dataset, a large ongoing prospective population that includes cohorts born 1900 – 1960, combined with Norwegian national registry data. Using these population-representative cohorts have exceptionally detailed health and socioeconomic longitudinal data to address these issues. We will take advantage of specific events that create natural experiments. Our results will help to identify “sensitive periods” over the life course and how they mediate genetic risks of cognitive decline and ADRD.

阿尔茨海默氏病和相关痴呆症 (ADRD) 的患病率预计将增加三倍 2050. 目前，尚无已知的通过行为预防 ADRD 的有效治疗方法。因此，影响 ADRD 风险的变化至关重要，大约 35% 的 ADRD 风险是被认为可归因于现代家庭生活当前的变化。工作和工作可能对 ADRD 风险产生重要影响，因为工作和家庭结构个人生活和环境的多个方面可能与 ADRD 风险相关。然而，工作和家庭轨迹作为 ADRD 风险的途径和调节因素的研究还不够。我们的总体假设是，当代家庭模式和工作生活的变化有助于与年龄相关的认知变化和 ADRD 向“现代”家庭结构和工作的转变。任务在挪威发生得相对较早，独特的数据可用性允许这些变化进行前瞻性研究，以预测美国和其他国家 ADRD 即将发生的变化。我们将研究成年后家庭与工作的生命历程影响以及风险相互作用 ADRD 和老年人认知障碍的研究将通过利用特殊的方法来实现。挪威 HUNT（北特伦德拉格健康研究）数据集，大量持续的预期人群其中包括 1900 年至 1960 年出生的队列，并结合挪威国家登记数据。这些具有人口代表性的群体具有极其详细的健康和社会经济状况我们将利用纵向数据来解决这些问题。我们的结果将有助于识别生命过程中的“敏感期”。它们如何介导认知能力下降和 ADRD 的遗传风险。