Imaging of Cognition, Learning and Memory in Aging

衰老过程中认知、学习和记忆的成像

基本信息

批准号：
9913429
负责人：
YAAKOV STERN
金额：
$ 97.74万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913429
关键词：
3-Dimensional Adult Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Behavior Behavioral Brain Brain Pathology Cerebrovascular Circulation Clinical Cognition Cognitive Data Data Analyses Data Set Disease Elderly Functional Magnetic Resonance Imaging Genetic Image Impaired cognition Individual Individual Differences Learning Life Experience Life Style Link Measures Mediating Mediation Memory Methodology Methods Modeling Outcome Participant Pathology Pattern Positioning Attribute Positron-Emission Tomography Predisposition Probability Procedures Process Proxy Public Health Research Rest Risk Short-Term Memory Structure System Task Performances Testing Thick Time White Matter Hyperintensity Work age related age related cognitive change aging brain base behavior measurement brain morphology brain volume cognitive function cognitive performance cognitive reserve differential expression experience follow-up innovation insight longitudinal analysis mild cognitive impairment multimodality neuromechanism preservation prevent recruit relating to nervous system theories white matter young adult β-amyloid burden

项目摘要

The proposed research is aimed at better understanding the neural underpinnings of cognitive reserve (CR). We have postulated that CR moderates the relationship between age- or Alzheimer’s disease (AD)-related brain pathology and the clinical impact of that pathology. Our findings suggest that CR operates through individual differences in how tasks are processed in the brain and that we can use fMRI-measured task-related activation to understand these processing differences. We have also begun to look at the factors influencing brain integrity, or brain reserve (BR). The promise of better understanding CR and BR is that these concepts have implications for preservation of function over time, so the neural mechanisms underlying reserve are optimally studied in a longitudinal context. We propose to initiate longitudinal follow-up at 5 years of a large, well characterized, initially healthy group of young (n=50) and older (N=150) adults, in order to elucidate the neural mechanism underlying CR that help maintain BR and successful cognitive performance in the face of advancing age-related brain changes and AD pathology. These participants have already been studied at baseline with two fMRI tasks, as well as quantified measures of age- and AD-related brain changes and pathology, including MR measures of brain volume, cortical thickness, white matter hyperintensities, resting cerebral blood flow and default network integrity, as well quantified amyloid burden from Florbetaben PET. We have already identified candidate neural mechanisms for CR. We will determine whether differential expression of these CR networks in healthy elders is associated with reduced risk of important clinical outcomes including cognitive decline and developing mild cognitive impairment MCI or AD. We will also explore how measured CR and CR networks maintain BR and how they moderate the effect of observed brain changes and advancing AD pathology in order to preserve cognitive functioning.

拟议的研究旨在更好地理解认知储备（CR）的神经基础。我们假设 CR 调节与年龄或阿尔茨海默病 (AD) 相关的关系我们的研究结果表明，CR 通过脑病理学和该病理学的临床影响来发挥作用。大脑处理任务的方式存在个体差异，我们可以使用功能磁共振成像测量的任务相关为了了解这些处理差异，我们也开始研究影响因素。大脑完整性，或大脑储备（BR）是更好地理解 CR 和 BR 的希望。随着时间的推移，对功能的保存有影响，因此储备背后的神经机制是我们建议在 5 年的时间里进行纵向随访。特征明确、最初健康的年轻人（n = 50）和老年人（n = 150）组，以阐明 CR 背后的神经机制有助于维持 BR 和面对困难时成功的认知表现推进与年龄相关的大脑变化和 AD 病理学已经对这些参与者进行了研究。两项功能磁共振成像任务的基线，以及与年龄和 AD 相关的大脑变化的量化测量，病理学，包括脑容量、皮质厚度、白质高信号、静息的 MR 测量脑血流量和默认网络完整性，以及来自 Florbetaben PET We 的量化淀粉样蛋白负荷。已经确定了 CR 的候选神经机制，我们将确定是否存在差异。这些 CR 网络在健康老年人中的表达与重要临床风险的降低相关包括认知能力下降和轻度认知障碍 MCI 或 AD 在内的结果。探索测量的 CR 和 CR 网络如何维持 BR 以及它们如何调节观察到的大脑的影响改变和推进 AD 病理学，以保持认知功能。