3/3; Promoting resilience in children:Protocol Development for a Birth Cohort Study to Access Factors Impacting Neurodevelopment

3/3；

• 批准号: 10013563
• 负责人: ANDREW L ALEXANDER
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013563
• 关键词: 10 year old; Accounting; Address; Adolescent; Affect; Age; Agreement; Alcohol or Other Drugs use; Area; Biological; Birth; Brain; Brain Mapping; Child; Child Development; Child Health; Childhood; Cognitive; Cohort Studies; Collaborations; Collection; Communities; Complex; Consultations; Data; Data Collection; Databases; Development; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Ethical Issues; Ethics; Evaluation; Exposure to; Family; Foundations; Fright; Future; Genetic; Goals; Guidelines; Health; Health Promotion; Home environment; Human; Infant; Intervention; Investigation; Knowledge; Laws; Legal; Life; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Methodology; Modeling; Mothers; Near-Infrared Spectroscopy; Neuraxis; Neurocognitive; Opioid; Outcome; Participant; Personal Satisfaction; Phase; Phase II Clinical Trials; Pilot Projects; Policies; Postpartum Women; Poverty; Pregnancy; Pregnant Women; Protocols documentation; Research; Resources; Risk; Risk Factors; Safety; Sampling; Sedation procedure; Social Interaction; Specimen; Standardization; Structure; Substance Use Disorder; Surveys; Target Populations; Techniques; Testing; Time; Vulnerable Populations; Woman; Work; addiction; adverse childhood events; brain behavior; cognitive ability; cognitive development; cognitive performance; cognitive testing; cohort; critical period; design; early childhood; early life exposure; experience; fetal; flexibility; multidisciplinary; multimodality; myelination; neurodevelopment; neuroimaging; opioid exposure; opioid use; opioid use in pregnancy; peer support; phase 2 study; postnatal period; prenatal; prenatal exposure; protocol development; public health relevance; recruit; resilience; retention rate; social; social stigma

PROMOTING RESILIENCE IN CHILDREN: PROTOCOL DEVELOPMENT FOR A BIRTH COHORT STUDY TO ASSESS FACTORS IMPACTING NEURODEVELOPMENT ABSTRACT The first ten years of life are accompanied by rapid changes to the developing brain and cognitive abilities. A multitude of complex interacting factors including genetics, early-life exposure to substances, family and social interactions, and home and community environments can affect the trajectories of brain and cognitive development. Adequate investigations of these effects and interactions have been limited by several factors, including challenges associated with the recruitment and retention of pregnant women with prenatal substance use; the legal, ethical and regulatory issues associated with studies of substance-using pregnant women and children; and the difficulties of performing neuroimaging in infants and young children without sedation. These three linked and synergistic projects aim to address these challenges by developing effective research protocols to lay a foundation for a successful future large-scale, national HEALthy Brain and Cognitive Development (HBCD) birth cohort study, which will follow the developmental trajectories for a decade. Project 1 will develop protocols for recruitment and retention of a diverse sample of pregnant and postpartum women with oversampling of mothers with prenatal opioid use. Project 2 will identify ethical, legal and regulatory challenges for investigations in this vulnerable population, and subsequently define effective solutions to enable recruitment and study of these participants. Project 3 will develop and evaluate protocols for acquiring high-quality, quantitative neuroimaging measures with magnetic resonance imaging and functional near infrared spectroscopy, as well as assess effective strategies for measuring cognitive performance in young children, including those exposed to opioids. These linked projects are essential to address the major challenges with the planned HBCD study and will leverage a highly collaborative, multidisciplinary team; leading-edge neuroimaging techniques; and outstanding institutional resources.

促进儿童的复原力：出生队列研究方案的制定 评估影响神经发育的因素 抽象的 生命的前十年伴随着大脑发育和认知能力的快速变化。一个 多种复杂的相互作用因素，包括遗传、早年接触物质、家庭和社会 互动、家庭和社区环境会影响大脑和认知的轨迹 发展。对这些影响和相互作用的充分研究受到多种因素的限制， 包括与招募和保留孕妇提供产前物质相关的挑战 使用;与药物使用孕妇研究相关的法律、伦理和监管问题 孩子们;以及在没有镇静剂的情况下对婴幼儿进行神经影像学检查的困难。这些 三个相互关联和协同的项目旨在通过开展有效的研究来应对这些挑战 协议为未来成功的大规模国家健康大脑和认知奠定基础 发育（HBCD）出生队列研究，将跟踪十年的发育轨迹。项目 1 将制定招募和保留孕妇和产后妇女不同样本的协议 对产前使用阿片类药物的母亲进行过度抽样。项目 2 将确定道德、法律和监管 调查这一弱势群体面临的挑战，并随后制定有效的解决方案 促进这些参与者的招募和研究。项目 3 将开发和评估收购协议 通过磁共振成像和功能性近距成像进行高质量、定量的神经影像测量 红外光谱，以及评估测量年轻人认知表现的有效策略 儿童，包括接触阿片类药物的儿童。这些相互关联的项目对于解决主要问题至关重要 计划中的六溴环十二烷研究面临挑战，并将利用高度协作的多学科团队； 领先的神经影像技术；和优秀的机构资源。