Toward Healthy Aging in Adults with Autism: A Longitudinal Clinical and Multimodal Brain Imaging Study

成年自闭症患者健康老龄化：纵向临床和多模态脑成像研究

• 批准号: 10523387
• 负责人: ANDREW L ALEXANDER
• 金额: $ 231.94万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523387
• 关键词: Adult; Affect; Age; Age-Years; Aging; Biological Aging; Brain; Brain imaging; Clinical; Cognitive aging; Communities; DNA; DNA Methylation; Data; Data Coordinating Center; Data Set; Databases; Dementia; Disease; Elderly; Enrollment; Epigenetic Process; Family history of; Female; Foundations; Genetic; Genetic Processes; Goals; Health; Health Promotion; Impaired cognition; Individual; Individual Differences; Learning; Life Expectancy; Life Style; Longitudinal Studies; Longitudinal cohort study; Longitudinal prospective study; Measurement; Measures; Mental Health; Mental disorders; Motor; Nerve Degeneration; Neurobiology; Neurocognition; Neurologic; Older Population; Outcome; Participant; Personal Satisfaction; Persons; Predictive Factor; Prevalence; Protocols documentation; Psyche structure; Psychiatric Diagnosis; Psychopathology; Reporting; Research; Resources; Role; Sampling; Science; Services; Severities; Siblings; Statistical Data Interpretation; Structure; Time; Universities; Utah; Variant; Visit; Wisconsin; adult with autism spectrum disorder; age effect; age related; autism spectrum disorder; autistic; base; cognitive function; cohort; comorbid depression; comorbidity; data curation; disability; functional disability; healthy aging; high dimensionality; imaging study; improved; improved outcome; individuals with autism spectrum disorder; innovation; male; motor disorder; multimodality; neuroimaging; physical conditioning; polygenic risk score; population health; prospective; psychiatric comorbidity; recruit; research study; resilience; sex; therapy development; trait; young adult

PROJECT SUMMARY/ABSTRACT Autism spectrum disorder (ASD) is a lifelong disorder that has consequences throughout adulthood. Recent population health studies indicate that aging autistic adults have shorter life expectancy and increased rates of physical and mental health problems. However, there is a paucity of studies that have focused on the progression of health and wellness with aging in ASD and factors that can contribute to better or worse outcomes. In this Autism Center of Excellence (ACE) Network project, the Interdisciplinary Science to Learn about Autism – Aging (ISLA-A) Network will deploy a harmonized, optimized, and innovative protocol to investigate the effects of aging in autism in one of the largest prospective longitudinal cohort studies of autistic adults to date. The aims of the ISLA-A center are 1) to establish and follow a large cohort of autistic male and female adults, siblings and age- and sex- matched non-autistic adults with a comprehensive harmonized research protocol to investigate multi- modal aspects of aging, including measures of clinical severity, physical and mental health, cognitive aging, brain structure and function, and epigenetic measures of biological aging; 2) to characterize both group and individual age-related changes in autism severity, health, wellness and brain measures with aging; 3) to investigate the relationships between clinical, health, and brain imaging measures; and 4) to investigate whether biological aging is accelerated in autism using new epigenetic measures of aging. The overarching goal of the ISLA-A Network is to create a comprehensive, harmonized, and high-dimensional dataset that will characterize trajectories of aging in autism that may be used to investigate whether early or accelerated aging is a hallmark feature of autism, and how aging in autism influences health and brain outcomes. The inclusion of siblings, who share genetics with the autistic adult cohort, will help to identify autism-specific factors related to aging and outcomes. The ISLA-A study results will identify candidate factors that are predictive to autism aging outcomes and will guide the development of interventions and services to improve outcomes. This new large, multi-modal, longitudinal, and generalizable dataset will be shared with the autism research community for independent studies. Overall, the ISLA-A Network study will generate a rich, high-impact resource for better understanding of aging in autism, with the ultimate goal of improving the health and support of autistic adults.

项目概要/摘要 自闭症谱系障碍 (ASD) 是一种终生疾病，会对整个成年期产生影响。 人口健康研究表明，老年自闭症患者的预期寿命较短，且患病率较高 然而，很少有研究关注其进展情况。 自闭症谱系障碍 (ASD) 中年龄增长对健康和保健的影响以及可能导致更好或更差结果的因素。 自闭症卓越中心 (ACE) 网络项目，了解自闭症的跨学科科学 – 衰老 (ISLA-A) 网络将部署协调、优化和创新的协议来研究衰老的影响 迄今为止对自闭症成人进行的最大的纵向前瞻性队列研究之一。 ISLA-A 中心的目标是 1) 建立并跟踪一大群自闭症男性和女性成年人、兄弟姐妹和年龄- 和性别匹配的非自闭症成年人，采用全面协调的研究方案来调查多 衰老的模式方面，包括临床严重程度、身心健康、认知衰老的测量， 大脑结构和功能，以及生物衰老的表观遗传测量；2）表征这两个群体和 随着年龄的增长，自闭症严重程度、健康状况、健康状况和大脑测量值发生与年龄相关的变化； 调查临床、健康和脑成像测量之间的关系；4) 调查是否 使用新的表观遗传学衰老指标可以加速自闭症患者的生物衰老。 ISLA-A Network 旨在创建一个全面、协调和高维的数据集，该数据集将表征 自闭症的衰老轨迹可用于早期调查是否加速衰老是一个标志 自闭症的特征，以及自闭症的衰老如何影响健康和大脑结果。 与自闭症成人群体共享遗传学，将有助于识别与衰老和自闭症相关的特定因素 ISLA-A 研究结果将确定预测自闭症衰老结果的候选因素。 并将指导干预措施和服务的发展，以改善结果。 纵向和可概括的数据集将与自闭症研究界共享，以供独立研究 总体而言，ISLA-A 网络研究将产生丰富的、高影响力的资源，以便更好地了解 自闭症的老龄化，最终目标是改善自闭症成年人的健康和支持。