Brain Imaging Core

脑成像核心

• 批准号: 10450731
• 负责人: ANDREW L ALEXANDER
• 金额: $ 19.22万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450731
• 关键词: Animal Model; Anxiety; Behavioral; Blood flow; Brain; Brain imaging; Cerebrum; Communities; Computer Systems; Computer software; Consultations; Data; Data Analytics; Data Storage and Retrieval; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Educational workshop; Energy Metabolism; Ensure; Environment; Exhibits; Experimental Designs; Functional Magnetic Resonance Imaging; Goals; High Performance Computing; Human; Image; Image Analysis; Individual; Infrastructure; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; MRI Scans; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Methodology; Methods; Modality; Molecular; Morphologic artifacts; Motion; Nerve Degeneration; Neurosciences; Neurotransmitters; Participant; Performance; Perfusion; Physics; Physiologic pulse; Physiological; Physiology; Population; Positron-Emission Tomography; Procedures; Protocols documentation; Quality Control; Radiopharmaceuticals; Research; Research Personnel; Research Project Grants; Resolution; Resources; Rest; Risk; Rodent; Scanning; Scientist; Sensory Receptors; Services; Software Tools; Spectrum Analysis; Statistical Data Interpretation; Structure; Students; System; Systems Development; Talents; Technical Expertise; Technology; Training; Update; animal imaging; base; behavioral phenotyping; computer science; data acquisition; design; functional near infrared spectroscopy; human model; image processing; imaging modality; imaging scientist; insight; instrument; meetings; neural correlate; neural patterning; neurochemistry; neurodevelopment; neuroimaging; neuropathology; nonhuman primate; novel; novel marker; protocol development; radiotracer; relating to nervous system; statistics; tool; white matter

Waisman Center investigators study intellectual and developmental disabilities (IDD) through investigating the brain structure and function in both animal models and individuals exhibiting or at risk for these conditions. The Waisman Brain Imaging Core (BIC) provides all of the tools and services required for these investigations and includes facilities for magnetic resonance imaging (MRI), human positron emission tomography (PET), high- resolution PET for animal imaging, ancillary physiological recordings during imaging, and extensive software tools and training for image analysis. This facility occupies a key role in providing systems level neuroscience that lies at the interface between the neurodevelopment, behavioral and molecular levels of analysis. The specific aims for for the Brain Imaging Core are: Aim 1 to develop MRI, PET, fNIRS hardware, methodologies and software technologies for neuroimaging studies of normal development, atypical development, and neurodegeneration in both humans and animal models. The objectives of this aim encompass all of the available neuroimaging modalities and resources available for IDD investigators. We also provide access to a highly realistic MRI simulator to enable participants to acclimate to the procedures and rehearse the behavioral protocols that are used in scanning. Aim 2 to provide expertise and guidance for neuroimaging protocol development and experimental design to UW-Madison investigators for studying IDD populations and animal models. The objectives of this aim are to ensure IDD investigators have access to technical expertise in neuroimaging methods as they plan, initiate and conduct their research projects. The BIC is staffed with highly skilled imaging scientists with expertise in MRI pulse sequence design, PET neuroreceptor imaging, radiopharmaceutical development, rodent and nonhuman primate imaging and data analytics. Aim 3 to provide training and technical support for investigators and their staffs in the use of all of the imaging modalities in the BIC. The objectives of this aim include the conduct of courses and training workshops, regular technical updates at BIC monthly meetings and lab meetings of the participating PIs, specialized consultation with the staff and students of PIs, development of specialized scanning sequences and data acquisition protocols for novel applications and consultation and support in statistical analysis of imaging data. The overall activities and function of the BIC will be directed by the goal of enriching the UW neuroscience community to disseminate ideas, implement plans and train neuroimaging scientists for research in IDDs.

魏斯曼中心的研究人员通过调查智力和发育障碍（IDD） 动物模型和表现出这些病症或有这些病症风险的个体的大脑结构和功能。这 Waisman 脑成像核心 (BIC) 提供这些调查所需的所有工具和服务， 包括磁共振成像 (MRI)、人体正电子发射断层扫描 (PET)、高 用于动物成像的分辨率 PET、成像过程中的辅助生理记录以及丰富的软件 图像分析工具和培训。该设施在提供系统级神经科学方面发挥着关键作用 它位于神经发育、行为和分子水平分析之间的界面。具体的 脑成像核心的目标是： 目标 1 开发 MRI、PET、fNIRS 硬件、方法和 用于正常发育、非典型发育和神经影像学研究的软件技术 人类和动物模型中的神经退行性变。该目标的目标涵盖了所有可用的 IDD 研究人员可用的神经影像模式和资源。我们还提供访问高度 逼真的 MRI 模拟器，使参与者能够适应程序并排练行为 扫描中使用的协议。目标 2 为神经影像方案提供专业知识和指导 为威斯康星大学麦迪逊分校研究人员研究 IDD 人群和动物提供开发和实验设计 模型。这一目标的目的是确保 IDD 调查人员能够获得以下领域的技术专业知识： 他们计划、启动和开展研究项目时使用神经影像方法。 BIC 拥有高素质的工作人员 熟练的成像科学家，在 MRI 脉冲序列设计、PET 神经感受器成像、 放射性药物开发、啮齿动物和非人类灵长类动物成像和数据分析。目标 3 提供 为调查人员及其工作人员提供使用所有成像方式的培训和技术支持 BIC。该目标的目标包括举办课程和培训研讨会、定期技术更新 在参与 PI 的 BIC 月度会议和实验室会议上，与工作人员进行专门咨询， PI 的学生，开发专门的扫描序列和数据采集协议 成像数据统计分析中的应用、咨询和支持。总体活动和 BIC 的职能将以丰富华盛顿大学神经科学界的目标为指导，以传播 想法、实施计划并培训神经影像科学家进行 IDD 研究。