High Performance Gradient System for Advanced Neuroimaging Research

用于高级神经影像研究的高性能梯度系统

• 批准号: 10176634
• 负责人: ANDREW L ALEXANDER
• 金额: $ 200万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176634
• 关键词: 10 year old; Aging; Area; Brain; Brain imaging; Dementia; Deposition; Diffusion Magnetic Resonance Imaging; Electronics; Funding; Grant; Head; Human; Magnetic Resonance Imaging; Neurosciences; Noise; Performance; Peripheral Nerve Stimulation; Protocols documentation; Research; Research Personnel; Resolution; Resources; Structure; System; Techniques; United States National Institutes of Health; Universities; Wisconsin; advanced system; affective neuroscience; connectome; design; developmental disease; digital; imaging capabilities; nervous system disorder; neurodevelopment; neuroimaging; next generation

ABSTRACT This grant will support the purchase of an ultrahigh-performance GE MAGNUS head gradient system to our 10+ year old research-dedicated 3-Tesla MRI system (GE MR750) in the Waisman Brain Imaging Lab (WBIL) at the University of Wisconsin – Madison (UW-Madison). The design of the MAGNUS head-only gradient system minimizes peripheral nerve stimulation, which uniquely enables extremely high gradient amplitudes and slew rates (200 mT/m and 500 T/m/s on each axis). The MAGNUS upgrade will provide major boosts in neuroimaging performance including reduced echo planar distortion and blurring, routine high-quality connectome brain imaging protocols with significantly higher spatial resolution, and extreme diffusion-weighted imaging capabilities. The MRI system upgrade also includes improvements to the system RF electronics through 64 low-noise digital receivers, reduced volume transmit coil with decreased RF power deposition, and a new 32-channel receiver head coil. The MAGNUS scanner will be a unique, high-end brain imaging research resource at UW-Madison for more than 18 investigators and 25 current projects, most of which are NIH- funded. Major areas of research that will be positively impacted include studies of aging and dementia, affective neuroscience, neurodevelopment and intellectual and developmental disorders, neurological disease, and basic neuroscience. The UW-Madison MAGNUS scanner will also be a cutting-edge neuroimaging research resource for new projects that will develop and apply next generation techniques to investigate brain structure, microstructure and function at finer scales and higher sensitivity than currently possible on any other human MRI scanner platform.

抽象的 这笔赠款将支持我们的实验室购买超高性能 GE MAGNUS 头部梯度系统 Waisman 脑成像实验室 (WBIL) 拥有 10 多年历史的研究专用 3-Tesla MRI 系统 (GE MR750) 威斯康星大学麦迪逊分校（UW-Madison）的 MAGNUS 仅头部梯度设计。 系统最大限度地减少周围神经刺激，从而独特地实现极高的梯度幅度和 MAGNUS 升级将大幅提升转换速率（每个轴为 200 mT/m 和 500 T/m/s）。 神经影像性能，包括减少回波平面失真和模糊，常规高质量 连接组脑成像协议具有显着更高的空间分辨率和极端的扩散加权 MRI 系统升级还包括系统射频电子设备的改进。 通过 64 个低噪声数字接收器、减小体积的发射线圈以及减少的射频功率沉积，以及 新型 32 通道接收器头部线圈 MAGNUS 扫描仪将成为独特的高端脑成像研究。 威斯康星大学麦迪逊分校为超过 18 名研究人员和 25 个当前项目提供资源，其中大部分是 NIH- 受到资助的主要研究领域包括衰老和痴呆症的研究， 情感神经科学、神经发育和智力和发育障碍、神经系统疾病、 威斯康辛大学麦迪逊分校 MAGNUS 扫描仪也将是一种尖端的神经影像学。 新项目的研究资源，这些项目将开发和应用下一代技术来研究大脑 比目前任何其他方法更精细的尺度和更高的灵敏度的结构、微观结构和功能 人体 MRI 扫描仪平台。