Motion Robust Relaxometry for Infant Neuroimaging

用于婴儿神经影像的运动鲁棒松弛测量法

基本信息

批准号：
10583970
负责人：
ANDREW L ALEXANDER
金额：
$ 62.92万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-20 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10583970
关键词：
2 year old 3-Dimensional Acoustics Address Adult Affect Age Age-Months Area Attenuated Axon Basal Ganglia Brain Brain Injuries Brain imaging Brain region Cerebral Palsy Child Child Development Childhood Clinical Clinical Research Clinical/Radiologic Cone Detection Development Diagnosis Disabled Children Disease Environment Evaluation Future Genetic Genetic Diseases Head Image Imaging Techniques Imaging technology Impairment Individual Individual Differences Infant Infant Development Intervention Lesion Life Longevity Loudness Machine Learning Magnetic Resonance Imaging Maps Measurement Measures Methods Morphologic artifacts Motion Motor Movement Disorders Myelin Neurologic Noise Outcome Pathology Pediatric Research Performance Persons Population Prognostic Marker Property Protocols documentation Radial Relaxation Resources Risk Scanning Sedation procedure Sensorimotor functions Sleep Software Tools Standardization Techniques Technology Testing Thalamic structure Time Toddler brain abnormalities brain tissue clinical diagnostics cohort developmental disease high risk image reconstruction imaging modality imaging study improved ischemic lesion multimodality myelination nervous system disorder neuroimaging novel pediatric patients precision medicine pressure prognostic prognostic value public health relevance quantitative imaging research study side effect sound spinal tract success tool white matter white matter damage

项目摘要

ABSTRACT: Quantitative relaxometry is a promising method for quantifying brain changes with early development and brain tissue differences as a function of genetics, environment or pathology. Relaxometry may be useful for assessing abnormal white matter damage in infants at risk for cerebral palsy, which is the leading movement disorder in children. Head motion is a significant challenge for MRI studies in young children, resulting in image artifacts and errors in quantitative imaging measures. Long and loud scans also adversely affect imaging compliance in young children. Consequently, there is a critical need to develop imaging methods that are robust to motion, faster, and quieter. This project will develop, optimize and evaluate novel 3D radial imaging technologies for multimodal structural imaging and quantitative relaxometry for studies in sleeping infants and toddlers. The outcome will be a fast, ultra-quiet imaging technique capable of providing imaging maps of quantitative relaxation times that are robust to nearly all motions. These optimized, motion-corrected, quantitative relaxometry technologies will be applied to a cohort of infants and toddlers without sedation to generate developmental relaxometry templates for normative studies from 0 to 2 years of age. The normative relaxometry framework will be applied to lesions and abnormal brain development of infants at risk for or diagnosed with cerebral palsy, The normative framework will also be used to investigate individual differences in brain and sensorimotor development in both typical development and cerebral palsy. Ultimately, this project will provide a set of robust, reliable and accurate image acquisition methods, software tools, and strategies for investigating healthy and abnormal brain development in both clinical and research pediatric populations without sedation.

抽象的：定量松弛测量法是一种很有前途的方法，可以量化早期大脑的变化。发育和脑组织差异作为遗传、环境或病理。松弛测量法可能有助于评估脑白质异常损伤婴儿有患脑瘫的风险，脑瘫是儿童中主要的运动障碍。头部运动对于幼儿 MRI 研究来说是一个重大挑战，导致定量成像测量中的图像伪影和误差。长而大声的扫描也对幼儿的影像依从性产生不利影响。因此，有一个关键的需要开发对运动稳定、更快、更安静的成像方法。这该项目将开发、优化和评估新型 3D 径向成像技术用于睡眠研究的多模态结构成像和定量松弛测量婴儿和幼儿。结果将是一种快速、超安静的成像技术提供对几乎所有情况都稳健的定量弛豫时间成像图议案。这些优化的、运动校正的定量松弛测量技术将应用于一组无需镇静的婴儿和幼儿，以产生用于 0 至 2 岁规范研究的发育松弛测量模板。规范的松弛测量框架将应用于病变和异常的大脑有脑瘫风险或被诊断患有脑瘫的婴儿的发育，规范框架还将用于研究大脑和典型发育和脑瘫中的感觉运动发育。最终，该项目将提供一套稳健、可靠、准确的图像采集方法，研究健康和异常大脑发育的软件工具和策略在无需镇静的临床和研究儿科人群中。