Training in Molecular Toxicology

分子毒理学培训

• 批准号: 8101169
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 26.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8101169
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This training grant will support pre-doctoral and postdoctoral students in the Molecular Toxicology Interdepartmental Program (IDP) at the University of California, Los Angeles (UCLA). Prior to the establishment of the IDP in 2000, toxicological research and training was scattered through many departments at UCLA, and lacked cohesion and coordination. Establishment of the IDP focused training in one program and stimulated interactions and collaborations among the participating faculty and their students and postdoctoral fellows. The training grant will help further consolidate, improve and expand the Molecular Toxicology Program, and signal the "arrival" of toxicology as an important player in the biomedical sciences at UCLA. The nine faculty of the training grant have their primary appointments in seven different departments in three different schools. Nevertheless their laboratories/offices are in close proximity to one another. The faculty members have substantial NIEHS funding. Most importantly, they have a common interest in the mechanisms whereby toxicants induce disease. Several of the faculty members investigate the role of air pollution particulates in the exacerbation of asthma. Others investigate the carcinogenic/mutagenic effects of these and other environmental pollutants. A new area for the program is the role of pesticides in the etiology of Parkinson's disease. Capitalizing on their experience with ambient air particles, some of the faculty have begun research on the emerging field of the toxicity of manufactured nanoparticles (nanotoxicology). One pre- and one postdoctoral position is requested in the first year. These numbers will progressively increase to four and two, respectively, in the fifth year. Pre-doctoral students will be supported for up to three years after they have completed their first year of course work. Postdoctoral fellows will receive two years of support. Five of the nine mentoring faculty are physician-scientists. These faculty members will provide an avenue for the recruitment of physicians to postdoctoral positions in the training grant. The grant is highly relevant to public health. A better understanding of the processes whereby air pollution, pesticides and other environmental pollutants cause diseases, including asthma, cancer, and/or Parkinson's disease, will lead to improved risk assessment as well as methodologies for reducing or eliminating the deleterious effects of these environmental agents. BACKGROUND This is a resubmission of an application for a training grant in Molecular Toxicology at UCLA. This revised application has undergone substantial revision to address concerns of the previous review. Training grant preceptors without R01 type funding have been omitted and the number of preceptors has decreased from fifteen to nine. Course requirements have been changed to reflect the addition of more toxicology courses. Previous incomplete sections/tables are now generally complete. Dr. Hankinson, the Program Director, presented that among the 9 faculty members included in this current training grant, 7 now have substantial NIEHS funding. In response to the concern that none of the mentors is affiliated with environmental health sciences, Dr. Hankinson points out that one of the new members of the faculty (Dr. Froines) is a Professor in the Department of Environmental Health Sciences, while two other members of the faculty (Drs. Ritz and Schiestl) have secondary appointments in that Department. He also points out that it should be noted that the Molecular Toxicology Program is an interdepartmental program, and believes that the resulting broad perspective represents one of the strengths of the program.

描述（由申请人提供） 这项培训补助金将支持洛杉矶分校（UCLA）分子毒理学互毒学跨部门计划（IDP）中的博士前和博士后学生。 在2000年建立IDP之前，毒理学研究和培训分散在UCLA的许多部门，缺乏凝聚力和协调性。在一个计划中建立了以IDP为中心的培训，并激发了参与教师及其学生和博士后研究员之间的互动和合作。培训赠款将有助于进一步巩固，改善和扩展分子毒理学计划，并指示毒理学作为UCLA生物医学科学的重要参与者的“到达”。培训补助金的九位教职员工在三所不同学校的七个不同部门任命。然而，他们的实验室/办公室彼此紧密近。教职员工拥有大量的NIEHS资金。最重要的是，它们对毒性诱导疾病的机制具有共同的兴趣。一些教职员工研究了空气污染颗粒在哮喘加重中的作用。 其他人研究了这些和其他环境污染物的致癌/诱变作用。 该计划的一个新领域是农药在帕金森氏病的病因中的作用。 利用他们在环境空气颗粒方面的经验，一些教师已经开始研究生产纳米颗粒的毒性（纳米毒理学）的新兴领域。 第一年请求一个前和一个博士后职位。这些数字将在第五年逐渐增加到四个和两个。博士前的学生完成课程的第一年后，将最多支持三年。博士后研究员将获得两年的支持。九位指导教师中有五个是医师科学家。这些教职员工将为招募医生在培训补助金的博士后职位提供途径。该赠款与公共卫生高度相关。更好地了解空气污染，农药和其他环境污染物引起的疾病，包括哮喘，癌症和/或帕金森氏病，将导致改善风险评估以及减少或消除这些环境药物的有害效果的方法。 背景 这是加州大学洛杉矶分校分子毒理学培训培训补助的申请。 该修订的应用程序已进行了大量修订，以解决上一篇评论的关注。 没有R01型资金的培训赠款受体受体，并且受体的数量已从15个减少到九个。 课程要求已更改，以反映更多毒理学课程的增加。 现在通常完成了以前的不完整部分/表格。 计划主任汉金森博士（Hankinson）博士指出，在本培训赠款中包括的9名教职员工中，有7位拥有大量的NIEHS资金。 汉金森博士指出，为了回应关心的导师隶属于环境健康科学，该学院的一位新成员（Froines博士）是环境卫生科学系的教授，而教职员工的另外两名成员（Ritz和Schiestl博士）在该部门有次要任命。他还指出，应该指出的是，分子毒理学计划是部门间计划，并认为由此产生的广泛观点代表了该计划的优势之一。