Training in Molecular Toxicology

分子毒理学培训

• 批准号: 8101169
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 26.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8101169
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This training grant will support pre-doctoral and postdoctoral students in the Molecular Toxicology Interdepartmental Program (IDP) at the University of California, Los Angeles (UCLA). Prior to the establishment of the IDP in 2000, toxicological research and training was scattered through many departments at UCLA, and lacked cohesion and coordination. Establishment of the IDP focused training in one program and stimulated interactions and collaborations among the participating faculty and their students and postdoctoral fellows. The training grant will help further consolidate, improve and expand the Molecular Toxicology Program, and signal the "arrival" of toxicology as an important player in the biomedical sciences at UCLA. The nine faculty of the training grant have their primary appointments in seven different departments in three different schools. Nevertheless their laboratories/offices are in close proximity to one another. The faculty members have substantial NIEHS funding. Most importantly, they have a common interest in the mechanisms whereby toxicants induce disease. Several of the faculty members investigate the role of air pollution particulates in the exacerbation of asthma. Others investigate the carcinogenic/mutagenic effects of these and other environmental pollutants. A new area for the program is the role of pesticides in the etiology of Parkinson's disease. Capitalizing on their experience with ambient air particles, some of the faculty have begun research on the emerging field of the toxicity of manufactured nanoparticles (nanotoxicology). One pre- and one postdoctoral position is requested in the first year. These numbers will progressively increase to four and two, respectively, in the fifth year. Pre-doctoral students will be supported for up to three years after they have completed their first year of course work. Postdoctoral fellows will receive two years of support. Five of the nine mentoring faculty are physician-scientists. These faculty members will provide an avenue for the recruitment of physicians to postdoctoral positions in the training grant. The grant is highly relevant to public health. A better understanding of the processes whereby air pollution, pesticides and other environmental pollutants cause diseases, including asthma, cancer, and/or Parkinson's disease, will lead to improved risk assessment as well as methodologies for reducing or eliminating the deleterious effects of these environmental agents. BACKGROUND This is a resubmission of an application for a training grant in Molecular Toxicology at UCLA. This revised application has undergone substantial revision to address concerns of the previous review. Training grant preceptors without R01 type funding have been omitted and the number of preceptors has decreased from fifteen to nine. Course requirements have been changed to reflect the addition of more toxicology courses. Previous incomplete sections/tables are now generally complete. Dr. Hankinson, the Program Director, presented that among the 9 faculty members included in this current training grant, 7 now have substantial NIEHS funding. In response to the concern that none of the mentors is affiliated with environmental health sciences, Dr. Hankinson points out that one of the new members of the faculty (Dr. Froines) is a Professor in the Department of Environmental Health Sciences, while two other members of the faculty (Drs. Ritz and Schiestl) have secondary appointments in that Department. He also points out that it should be noted that the Molecular Toxicology Program is an interdepartmental program, and believes that the resulting broad perspective represents one of the strengths of the program.

描述（由申请人提供） 这笔培训补助金将支持加州大学洛杉矶分校 (UCLA) 分子毒理学跨部门计划 (IDP) 的博士前和博士后学生。 在2000年IDP成立之前，毒理学研究和培训分散在加州大学洛杉矶分校的多个部门，缺乏凝聚力和协调。 IDP 的建立将培训集中在一个项目中，并刺激了参与的教师及其学生和博士后研究员之间的互动和合作。培训资助将有助于进一步巩固、改进和扩大分子毒理学项目，并标志着毒理学作为加州大学洛杉矶分校生物医学科学的重要参与者的“到来”。获得培训补助金的九名教师在三所不同学校的七个不同部门担任主要职务。然而，他们的实验室/办公室彼此非常接近。教职员工获得了大量 NIEHS 资助。最重要的是，他们对毒物诱发疾病的机制有着共同的兴趣。几位教职员工研究了空气污染颗粒物在哮喘恶化中的作用。 其他人则研究这些和其他环境污染物的致癌/致突变作用。 该计划的一个新领域是农药在帕金森病病因学中的作用。 利用他们在环境空气颗粒方面的经验，一些教师已经开始对人造纳米颗粒的毒性这一新兴领域（纳米毒理学）进行研究。 第一年要求一个博士前职位和一个博士后职位。到第五年，这些数字将分别逐渐增加到四个和两个。博士前学生在完成第一年的课程后将获得长达三年的支持。博士后研究员将获得两年的支持。九名导师中有五名是医师科学家。这些教职人员将为在培训补助金中招聘医生担任博士后职位提供途径。该赠款与公共卫生高度相关。更好地了解空气污染、农药和其他环境污染物导致疾病（包括哮喘、癌症和/或帕金森病）的过程，将有助于改进风险评估以及减少或消除这些环境因素的有害影响的方法。 背景 这是加州大学洛杉矶分校分子毒理学培训资助申请的重新提交。 此修订后的申请进行了实质性修改，以解决先前审查的问题。 没有 R01 类资助的培训补助导师已被取消，导师人数从 15 人减少到 9 人。 课程要求已更改，以反映增加的更多毒理学课程。 以前不完整的部分/表格现在已基本完成。 项目主任 Hankinson 博士表示，在本次培训资助的 9 名教员中，有 7 人现在获得了 NIEHS 的大量资助。 针对没有一位导师与环境健康科学相关的担忧，汉金森博士指出，该学院的一位新成员（Froines 博士）是环境健康科学系的教授，而另外两位则是环境健康科学系的教授。教职人员（Ritz 博士和 Schiestl 博士）在该系担任二级职务。他还指出，应该指出的是，分子毒理学计划是一个跨部门的计划，并认为由此产生的广泛视角代表了该计划的优势之一。