Sensory Mechanisms of Cadmium-Induced Behavioral Disorders Across Generations

镉引起的几代人行为障碍的感觉机制

• 批准号: 10747559
• 负责人: Delia S Shelton
• 金额: $ 5.02万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-25 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10747559
• 关键词: Ablation; Acute; Adolescent; Adult; Adverse effects; Affect; Agriculture; Animal Behavior; Animals; Applications Grants; Area; Attention Deficit Disorder; Behavior; Behavior Disorders; Behavioral; Biological; Biological Assay; Biology; Brain; Cadmium; Calcium; Calcium Oscillations; Carcinogens; Cells; Chemicals; Child; Chocolate; Chronic; Cognitive; Complement; Data; Depressed mood; Development; Diet; Dietary Cadmium; Dietary Supplementation; Disease; Doctor of Philosophy; Elderly; Environment; Environmental Risk Factor; Environmental Wind; Epigenetic Process; Etiology; Exposure to; Eye; Fishes; Food; Fruit; Future Generations; Gene Expression; Generations; Genetic; Genomics; Goals; Grain; Grant; Half-Life; Health; Heavy Metals; Human; Immunohistochemistry; Immunotoxins; Inductively Coupled Plasma Mass Spectrometry; Industrialization; Ingestion; Intake; Knowledge; Laboratories; Lasers; Learning; Life; Link; Maps; Meat; Memory; Mental Retardation; Mental disorders; Mentors; MicroRNAs; Modeling; Molecular Biology; Mutagens; National Institute of Environmental Health Sciences; Necrosis; Neurodevelopmental Disorder; Neuropsychology; Neurosciences; Ocular Pathology; Outcome; Pathology; Pathway interactions; Peer Review; Perception; Phase; Population; Prevalence; Prevention; Publications; Quantitative Reverse Transcriptase PCR; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Reticular Formation; Science; Selenium; Social Behavior; Social Development; Soil; Technical Expertise; Testing; Therapeutic Effect; Time; Tissues; Toxic effect; Toxicogenomics; Toxicology; Transgenic Organisms; Universities; Vegetables; Vision; Visual; Visual impairment; Visualization; Water; Work; Zebrafish; autism spectrum disorder; behavioral phenotyping; career; career development; dietary; epidemiology study; experience; hindbrain; intergenerational; neural; neural circuit; neurobehavioral; neurobehavioral disorder; neurocognitive disorder; next generation sequencing; non-smoking; novel; parent grant; professor; programs; reproductive; research and development; response; sensory mechanism; skills; superior colliculus Corpora quadrigemina; symposium

PROJECT SUMMARY/ABSTRACT An area of needed exploration is environmentally-induced behavioral disorders. Studies show Cadmium (Cd) toxicity can manifest as behavioral disorders, cognitive challenges, and vision deficiencies in humans, but the pathway for these adverse effects is unknown. Its long biological half-life exacerbates the importance of understanding how early-life Cd exposure impacts later life outcomes and future generations. The parent grant has two aims focused on gaining a mechanistic understanding of cadmium-induced behavioral disorders across generations. Specific Aim 1: Identify the disrupted neural circuitry underlying cadmium-induced visuo-behavioral deficits using whole-brain activity mapping. Specific Aim 2: Inter- and transgenerational effects of cadmium-induced behavioral disorders. The parent grant for this proposal is R00ES030398 to launch Dr. Delia Shelton’s career as an independent scientific investigator as an Assistant professor in the Department of Biology at University of Miami, where she draws on her scientific background in animal behavior, toxicology, neuroscience and genomics. Dr. Shelton has extensive experience in understanding behavioral phenotyping and cadmium toxicity which is completed by professional skills in mentoring that she gained in her graduate studies and during the K99 phase of the grant, permitting her to become a successful independent researcher and leader in behavioral toxicology. In her new laboratory, Dr. Shelton proposes to test the hypothesis that chronic human dietary-relevant Cd exposure leads to visuo-behavioral disorders later in life and across generations. In the proposed supplement, Dr. Shelton will mentor the Diversity Supplement candidate, Myles Covington, in pursuing a research project that complements and extends the aims of the parent grant, thereby creating a unique opportunity. The focus of this application submitted under PA-21-071 “Research Supplements to Promote Diversity in Health-Related Research” is to support the research training and career development of Myles Covington through studying the potential therapeutic effects of selenium supplementation for dietary cadmium-induced toxicity on visually- guided behavior. Research and career development activities are proposed to expand their technical skill set, enhance their knowledge in toxicology, molecular biology and genomics, and provide opportunities for professional development including networking disseminating science at conferences and through peer- reviewed publications, which will enhance their ability to pursue a PhD in toxico-genomics.

项目摘要/摘要 需要探索的领域是环境引起的行为障碍。研究表明镉（CD） 毒性可以表现为人类的行为障碍，认知挑战和视力缺陷，但 这些不良反应的途径尚不清楚。它的长期生物半衰期加剧了 了解早期生活的CD暴露如何影响以后的生活成果和后代。父母赠款 有两个目标重点是获得对镉诱导的行为障碍的机械理解 几代人。 特定目标1：确定镉诱导的视觉行为缺陷的神经回路破坏的神经回路 使用全脑活动映射。 特定目标2：镉诱导的行为障碍的间和变革性效应。 该提案的父母赠款是R00ES030398，以启动Delia Shelton博士的职业生涯 科学研究者是迈阿密大学生物学系的助理教授 借鉴了她在动物行为，毒理学，神经科学和基因组学方面的科学背景。谢尔顿博士 在理解行为表型和镉毒性方面具有丰富的经验 通过她在研究生学习和K99阶段获得的心理专业技能 格兰特（Grant），允许她成为成功的独立研究者和行为毒理学领导者。在 她的新实验室Shelton博士提出了一个假设，即慢性人类饮食中的CD 暴露会导致生活后期和几代人的视觉行为疾病。在拟议的补充剂中 谢尔顿博士将指导多样性补充候选人迈尔斯·卡温顿（Myles Covington）追求研究项目 完成并扩展了父母赠款的目标，从而创造了独特的机会。重点 在PA-21-071提交的该申请中，“研究补品以促进与健康有关的多样性 研究”是为了支持Myles Covington的研究培训和职业发展 补充硒对饮食镉诱导的毒性的潜在治疗作用对视觉 指导行为。提出了研究和职业发展活动来扩大其技术技能， 增强他们在毒理学，分子生物学和基因组学方面的了解，并为 专业发展，包括在会议上以及通过同行进行网络传播科学的网络 审查了出版物，这将增强他们在毒素基因组学中获得博士学位的能力。