Training in Molecular Toxicology

分子毒理学培训

• 批准号: 8667052
• 负责人: OLIVER nmn HANKINSON
• 金额: $ 20.7万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8667052
• 关键词: Molecular Toxicology; Training

DESCRIPTION (provided by applicant) This is a renewal of the training grant "Training in Molecular Toxicology" at UCLA that was first funded in 2008. The training grant has catalyzed the expansion and consolidation of molecular toxicological research and training at UCLA and has stimulated interactions and collaborations among the participating faculty and the pre- and postdoctoral trainees. During the current funding period, the number of training grant faculty members increased from nine to fourteen. The faculty has primary appointments in nine different departments at UCLA. Four of the new appointees are Assistant Professors, and represent potential future leaders of the program. Seven of the faculty members have M.D. degrees. These faculty provides a potential avenue for the recruitment of physician-scientists to postdoctoral (and perhaps also pre-doctoral) positions in the training grant. The training grant requests support for five years and for four pre-doctoral students in the Molecular Toxicology Interdepartment Doctoral Program (IDP) at UCLA, and two postdoctoral trainees in the laboratories of the training grant faculty. Pre-doctoral trainees wil usually be appointed for three years, and postdoctoral trainees will be appointed for up to two years. In general, only pre-doctoral trainees who have completed their first year (during which most do rotations) will be awarded positions on the training grant. This number of trainee positions requested is justified by the increase in the number of our faculty, their substantial NIEHS and non-NIEHS funding, the investigators' previous success in recruiting excellent pre-doctoral and postdoctoral trainees, and the excellent publication record of the trainees. The faculty has a common interest in the mechanisms whereby environmental toxins cause disease. There are four major foci of research interest: i) The role of pesticides in the etiology of Parkinson's disease, ii) genetic damage (including carcinogenesis) caused by environmental agents, (iii) the toxic effects of secondhand cigarette smoke and of fossil fuels and their combustion products, and iv) nanotoxicology. Other areas of research pursued by individual faculty include metal toxicity and the analysis of transcription networks in toxicity. The UCLA Vice Chancellor for Research very recently announced a "Grand Challenge" initiative. One of the six Challenges focuses on preventing diseases associated with energy, pesticides and environmental technologies. The training grant faculty and trainees are poised to make major contributions to this endeavor. The UCLA Academic Senate undertook an eight year review of the Molecular Toxicology IDP in 2010, and an External Advisory Committee reviewed the training grant in 2011. The Committees were clearly impressed with the IDP and the attainments of the training grant. UCLA has committed considerable resources to the Molecular Toxicology Program, and institutional support is very strong. Over the next five years the NIEHS training grant will further enhance and stimulate molecular toxicological research and training at UCLA, should encourage more students and postdoctoral fellows to pursue research in toxicology, and will signal the increasing importance of toxicology as a discipline at UCLA.

描述（由申请人提供） 这是UCLA上首次资助的UCLA培训补助金“分子毒理学培训”的续签。培训赠款催化了UCLA的分子毒理学研究和培训的扩张和巩固，并激发了参与教师以及前和后的受训者之间的互动和协作。在当前的资助期间，培训赠款教职员工的数量从九个增加到14个。该学院在加州大学洛杉矶分校的九个不同部门有主要任命。 新任命的四个是助理教授，代表该计划的潜在未来领导人。七个教职员工拥有医学博士学位。这些教师为招募医师科学家在培训补助金的博士后职位（也许也是博士前）职位提供了潜在的途径。培训赠款要求提供五年的支持和四个前博士 分子毒理学互动学博士学位课程（IDP）的学生，以及培训赠款教师实验室的两名博士后学员。 博士后学员通常会任命三年，而博士后学员将被任命长达两年。 一般而言，只有完成第一年（在此期间大多数轮换）的博士前学员才能获得培训补助金的职位。要求的这一数量的学员职位是合理的，这是合理的，我们的教师人数的增加，大量的NIEHS和非NIEHS资金，调查人员先前在招募出色的博士前和博士后学员方面取得了成功，以及受训者的出色出版物记录。该教师对环境毒素引起疾病的机制具有共同的兴趣。研究兴趣的四个主要焦点：i）农药在帕金森氏病病因中的作用，ii）遗传损害（包括癌变）是由环境剂引起的，（iii）二手香烟烟雾和化石燃料及其燃烧产物的毒性作用，以及其燃烧产物，以及IV）纳米毒学。个人教师追求的其他研究领域包括金属毒性和毒性中转录网络的分析。 UCLA研究副校长最近宣布了一项“大挑战”倡议。六个挑战之一的重点是预防与能源，农药和环境技术相关的疾病。培训补助金的教师和学员准备为这项努力做出重大贡献。加州大学洛杉矶分校的学术参议院于2010年对分子毒理学IDP进行了八年的审查，外部咨询委员会在2011年审查了培训赠款。委员会对IDP和培训赠款的成就显然给人留下了深刻的印象。加州大学洛杉矶分校（UCLA）为分子毒理学计划提供了大量资源，机构支持非常强大。在接下来的五年中，NIEHS培训补助金将进一步增强和刺激UCLA的分子毒理学研究和培训，应鼓励更多的学生和博士后研究员从事毒理学研究，并表明毒理学作为UCLA的学科的重要性越来越重要。