2023 Nitric Oxide GRC and GRS

2023 一氧化氮 GRC 和 GRS

• 批准号: 10608028
• 负责人: Andrew J Gow
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10608028
• 关键词: Address; Air Pollutants; Alzheimer' s Disease; Asthma; Athletic; Award; Bacteria; Basic Science; Biochemistry; Blood Vessels; Budgets; COVID-19 pandemic; COVID-19 patient; COVID-19 pneumonia; California; Carcinogens; Cardiopulmonary; Cardiovascular Diseases; Cardiovascular system; Chemistry; Collaborations; Communities; Complex; Consumption; Data; Detection; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Disease Resistance; Dose; Endothelium-Dependent Relaxing Factors; Environment; Enzymes; Explosion; Failure; Fostering; Functional disorder; Funding; Gender; Generations; Goals; Health; Health Status; Hemoglobin; Human; Human Biology; Human body; Hypertension; Inflammation; International; Life; Lung; Lung diseases; Mission; Molecular; Nature; Nitric Oxide; Nitric Oxide Synthase; Nitrous Oxide; Nobel Prize; Oral; Organism; Oxides; Participant; Pathology; Patients; Performance; Pharmacology and Toxicology; Physicians; Physiological; Physiology; Play; Postdoctoral Fellow; Preparation; Production; Reaction; Recording of previous events; Relaxation; Request for Proposals; Research; Research Personnel; Role; Running; Science; Scientist; Signal Pathway; Signal Transduction; Signaling Molecule; Source; Structure; System; Therapeutic; Therapeutic Intervention; Time; Training; Translational Research; United States National Institutes of Health; Universities; Vascular System; Work; body system; design; ethnic minority; experience; graduate student; human disease; improved; inhaled nitric oxide; insight; interest; meetings; member; neonatal pulmonary hypertension; next generation; novel; novel therapeutics; parity; posters; prevent; professor; programs; racial minority; respiratory health; skills; supportive environment; symposium; synergism

PROJECT SUMMARY This proposal requests partial support for a meeting on the “Molecular Mechanisms of Nitric Oxide Signaling in Health and Disease” as a Gordon Research Conference (GRC) and Gordon Research Seminar (GRS) to be held in Ventura California from February 12th -17th 2023. The broad and long-term goal of this conference is to bring together the world's leading researchers in this field to foster cross-disciplinary discussions and collaborations. The meeting is designed to enhance our understanding of Nitric Oxide as a regulator of physiological function and as such an important target for control in both health and disease. In particular, we are interested in emphasizing how restoring appropriate Nitric Oxide signaling can alleviate diseases as varied as diabetes, hypertension, asthma, and COVID-19 related pneumonia. The 2023 conference will include a GRS for trainees held immediately prior to and in conjunction with the GRC. The specific aims of this meeting will be to convene over 35 leading experts who will present unpublished data and insights within the field of Nitric Oxide research. The GRC program will be structured into 9 sessions that comprehensively cover the field with sessions focused on cardiovascular performance, molecular mechanisms of signaling, Nitric Oxide generation and detection, and the role of Nitric Oxide in respiratory health. Both basic and translational research will be highlighted, with a major emphasis on physiological signaling and disruptions of this system that can be targeted to improve human health. Afternoon poster sessions will permit all participants to contribute to these topics with the most meritorious abstracts chosen by the conference Chair and Vice-Chair for oral presentations. Every effort will be made to encourage participation by graduate students and postdoctoral fellows in the GRC. In addition, the GRS will be specifically aimed at trainees, allowing them to present their research and interact in a relaxing and extra supportive environment. Every effort will be made to promote gender parity and include racial/ethnic minorities and persons with disabilities. The significance of this application lies in the much needed forum provided by the GRC and GRS to bring together and synergize the members of an international research community working on Nitric Oxide. Nitric Oxide research is unique in that it brings together chemists, environmental scientists, pulmonary and cardiovascular physicians. The Gordon conference on NO which has run since 1995 provides one of the only venues that brings together this diverse group and promotes transformational research ideas. The GRS will have the added value of helping to train and energize the next generation of researchers in the field. The need for greater understanding of how Nitric Oxide is critical to normal human function has only been made more apparent in the recent COVID pandemic. Nitric Oxide based detection and delivery systems are currently in use to not only treat patients, but to improve general health levels and improve resistant to disease. The investigators brought together by this conference have the potential to bring about true transformational change in human health.

项目摘要 该提案要求部分支持“一氧化氮信号的分子机制 健康与疾病”作为戈登研究会议（GRC）和戈登研究研讨会（GRS） 2023年2月12日至17日在加利福尼亚州举行。这次会议的广泛和长期目标是 将该领域的世界领先研究人员汇集在一起​​，以促进跨学科讨论和 协作。会议旨在增强我们对一氧化氮作为调节器的理解 生理功能，也是健康和疾病控制的重要目标。特别是我们 有兴趣强调如何恢复适当的一氧化氮信号传导如何减轻各种各样的疾病 作为糖尿病，高血压，哮喘和Covid-19相关的肺炎。 2023会议将包括 直接在与GRC结合之前和结合GRC之前举行的学员。这次会议的具体目标 将召集超过35位领先的专家，他们将在现场介绍未发表的数据和见解 一氧化氮研究。 GRC计划将结构为9个会话，全面涵盖该领域 会议的重点是心血管表现，信号传导的分子机制，一氧化氮 产生和检测以及一氧化氮在呼吸健康中的作用。基本和翻译 研究将被强调，重点是该系统的物理信号和破坏 这可以针对改善人类健康。下午的海报会议将允许所有参与者 会议主席和副主席选择的最有功摘要促进这些主题 用于口头演示。将尽一切努力鼓励研究生和 GRC的博士后研究员。此外，GRS将专门针对培训，使他们能够 介绍他们的研究并在轻松和额外的支持环境中进行互动。将尽一切努力 促进性别平等，包括种族/族裔少数民族和残疾人。这一点的意义 申请在于GRC和GRS提供的急需的论坛，以汇集并协同化 一个从事一氧化氮的国际研究社区的成员。一氧化氮研究在 它汇集了化学家，环境科学家，肺部和心血管医师。 自1995年以来，戈登（Gordon）会议召开的戈登会议提供了唯一汇集此的场所之一 多样化的小组并促进了变革型研究思想。 GRS将具有帮助 训练该领域的下一代研究人员。需要更深入地了解如何 一氧化氮对正常人类功能至关重要 大流行。目前正在使用基于一氧化氮的检测和输送系统来治疗患者，而且还使用 提高一般健康水平并改善对疾病的抗性。调查人员聚集在一起 会议有可能实现人类健康的真正变革。