Brain Tissue Resource Center for Alcohol Research

酒精研究脑组织资源中心

基本信息

批准号：
8142049
负责人：
Jillian June Kril
金额：
$ 43.83万
依托单位：
UNIVERSITY OF SYDNEY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8142049
关键词：
Address Alcohol consumption Alcohol-Related Disorders Alcohols Animal Model Area Australia Autopsy Blood Banks Brain Brain Diseases Brain Injuries Clinical Collection Comorbidity DNA Data Development Diagnosis Disease Ensure Ethics Formalin Freezing Funding Future Genetic Health Human International Knowledge Laboratories Life Life Style Management Information Systems Medical History Molecular Biology Nervous system structure New South Wales Pathology Procedures Process Proteomics Protocols documentation Public Health Research Research Personnel Research Technics Resources Role Solutions Testing Tissues Training Universities Work alcohol research brain tissue disorder control innovation interest metabolomics neuroimaging neuropsychiatry new technology problem drinker programs prospective research study social socioeconomics tissue fixing tissue resource

项目摘要

DESCRIPTION (provided by applicant): Alcohol-related disorders of the nervous system are major public health and socio-economic problems throughout the world. Per capita consumption of alcohol in Australia is extremely high and, as a result alcohol related brain damage is common. The New South Wales Tissue Resource Center (TRC) at the University of Sydney has established itself as a useful resource for the facilitation of research into alcohol-related brain damage and associated conditions. The aim of this important and innovative facility is to provide fresh-frozen and formalin fixed tissue to research groups worldwide who are investigating these disorders. In addition, the TRC takes a leading role in the area of brain banking by developing standardized protocols, undertaking enhanced clinical characterization of cases, building better information systems management and by training staff. We have endeavoured to ensure the future viability of the TRC by developing a donor program called Using our Brains (donors sign up during life) that will expand our current collection procedures and provide more valuable, longitudinally characterized tissue for research studies. The donors have full life- style, medical histories and brain function documented. With this comes a social and ethical responsibility to ensure that the greatest benefit is obtained from the tissues donated. Brain banking is a long-term proposition and maximum benefits will be seen as case numbers increase. Using the same case material and applying different scientific techniques, research groups can generate data that can be related to pre-mortem clinical, laboratory and radiological information. We believe this is achieved by providing a bank that can be accessed by a diverse range of researchers. Funding is sought to further develop this important resource for international researchers with an interest in alcohol related brain damage. PUBLIC HEALTH RELEVANCE: Alcohol-related disorders of the nervous system are major public health and socio-economic problems throughout the world. A brain bank is a facilitator for research groups to study and find solutions for these disorders.

描述（由申请人提供）：与酒精相关的神经系统疾病是全世界主要的公共卫生和社会经济问题。澳大利亚的人均酒精消费量极高，因此与酒精相关的脑损伤很常见。悉尼大学新南威尔士州组织资源中心 (TRC) 已成为促进酒精相关脑损伤及相关病症研究的有用资源。这个重要的创新设施的目的是为世界各地正在研究这些疾病的研究小组提供新鲜冷冻和福尔马林固定的组织。此外，TRC 通过制定标准化协议、加强病例的临床特征、建立更好的信息系统管理和培训员工，在脑库领域发挥主导作用。我们通过开发一个名为“使用我们的大脑”（捐赠者在生前注册）的捐赠计划，努力确保 TRC 未来的生存能力，该计划将扩大我们当前的收集程序，并为研究提供更有价值的、纵向特征的组织。捐赠者有完整的生活方式、病史和大脑功能记录。随之而来的是社会和道德责任，以确保从捐赠的组织中获得最大的利益。脑库是一个长期的主张，随着病例数量的增加，将看到最大的效益。使用相同的案例材料并应用不同的科学技术，研究小组可以生成与尸检前临床、实验室和放射学信息相关的数据。我们相信，这是通过提供一个可供各种研究人员访问的银行来实现的。正在寻求资金，为对酒精相关脑损伤感兴趣的国际研究人员进一步开发这一重要资源。公共卫生相关性：与酒精相关的神经系统疾病是全世界主要的公共卫生和社会经济问题。脑库是研究小组研究和寻找这些疾病解决方案的促进者。