Brain Tissue Resource Center for Alcohol Research

酒精研究脑组织资源中心

基本信息

批准号：
10166728
负责人：
Jillian June Kril
金额：
$ 45.28万
依托单位：
UNIVERSITY OF SYDNEY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10166728
关键词：
Address Alcohol consumption Alcohol dependence Alcohol-Related Disorders Alcoholism Alcohols Amygdaloid structure Animals Area Autopsy Biology Brain Brain Injuries Brain region Cardiovascular Diseases Cessation of life Clinical Clinical Data Clinical Research Collection Complex Consent Consumption DSM-V Data Development Diagnosis Disease Drug usage Ensure Ethanol Exclusion Criteria Family Forensic Medicine Formalin Freezing Functional disorder Funding Genetic Predisposition to Disease Goals Government Health Care Costs Human Individual Infrastructure Institutional Ethics Knowledge Laboratories Life Style Liver Cirrhosis Liver diseases Magnetic Resonance Imaging Measures Medical Medical Records Mental Depression Mental disorders Methods Modification Molecular Monitor National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurosciences Research Nucleus Accumbens Organ Outcomes Research Paraffin Embedding Patients Protocols documentation Provider Public Health Publications Recording of previous events Recovery Research Research Design Research Methodology Research Personnel Research Project Grants Research Technics Resources Sampling Scanning Services Slide Societies Source Students Substance Use Disorder Techniques Test Result Tissue Banks Tissues Translational Research Universities Ventral Tegmental Area addiction alcohol consequences alcohol misuse alcohol research alcohol use disorder base biobank brain circuitry brain research brain tissue career case control cigarette smoking cognitive testing cohort comorbidity data archive data sharing design disorder control experience health economics illicit drug use improved inclusion criteria nervous system disorder next generation novel operation preclinical study prevent preventable death problem drinker professor programs prospective recruit relating to nervous system research study societal costs socioeconomics sound tissue resource treatment program

项目摘要

Project Summary Alcohol-related disorders are areas of major public health and socio-economic concern. Research aimed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol misuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from individuals with alcohol use disorders and matched controls. The NSW Brain Tissue Resource Center (BTRC) is a brain bank that was established to facilitate research into alcohol addiction and ARBD. It provides human post-mortem brain tissue, and associated clinical information, to researchers worldwide. Tissues are collected from individuals with alcohol use disorders and controls through a prospective donor program or from people undergoing forensic autopsy. Collection of tissue is closely monitored using a range of inclusion and exclusion criteria so as to maintain tissue quality for application to a wide variety research techniques. Tissues are prepared so that fresh frozen, formalin fixed and formalin fixed, paraffin embedded samples are available to researchers. Cases undergo a thorough neuropathologic examination and are assigned DSMIV and DSM 5 diagnoses following review of medical records and medical, family history and lifestyle information provided by the donor and/or their family. Cohorts of alcoholics and controls with and without complicating factors (e.g. comorbid cigarette smoking, liver disease or depression) are then established to allow researchers to tailor their study design to address questions of importance for alcohol misuse and alcoholism. Access to tissue is open to any researcher with institutional ethics approval. Requests for tissue are reviewed by an NIAAA convened Scientific Review Board to ensure appropriate and efficient use of the resource. The BTRC holds institutional ethics approval to collect, hold and distribute tissues and associated clinical data. Its operations are overseen by a Director, Professor Jillian Kril, Deputy Director, Dr Greg Sutherland, and Manager, Ms Donna Sheedy, all of whom have extensive experience in biobanking and have, over their careers, contributed more than 70 publications in the area of alcohol research. A Management Committee appointed by the University of Sydney provides oversight and guidance to the BTRC. The University of Sydney provides the infrastructure to house and operate the bank. Since its inception in 2000 the BTRC has facilitated over 110 research projects that have resulted in 207 publications on various aspects of alcohol misuse and alcoholism. In addition, projects have contributed to the research degrees of 194 students. The BTRC also contributes tissue and data to research projects on other aspects of neurological and psychiatric disease that have resulted in an addition 300+ publications.

项目概要酒精相关疾病是主要的公共卫生和社会经济问题领域。研究旨在预防成瘾和器官损伤，特别是酒精相关的脑损伤（ARBD），必须以细胞水平上酒精滥用的生物学知识为基础。这样的研究依赖于从患有此类疾病的个体中获取高质量、广泛表征的组织。酒精使用障碍和匹配的对照。新南威尔士州脑组织资源中心 (BTRC) 是一个脑库的建立是为了促进酒精成瘾和 ARBD 的研究。它提供向世界各地的研究人员提供人类死后脑组织以及相关的临床信息。通过前瞻性研究从患有酒精使用障碍和控制的个体中收集组织捐赠者计划或来自接受法医尸检的人。组织的收集受到密切监控使用一系列纳入和排除标准，以保持组织质量以应用于各种各样的研究技术。准备组织，新鲜冷冻，福尔马林固定并研究人员可以获得福尔马林固定、石蜡包埋的样品。案件经过彻底神经病理学检查，并在审查后分配 DSMIV 和 DSM 5 诊断捐赠者和/或其捐赠者提供的医疗记录以及医疗、家族史和生活方式信息家庭。酗酒者和对照组有或没有复杂因素（例如共病）的队列然后建立吸烟、肝病或抑郁症），以便研究人员能够调整他们的研究设计旨在解决酒精滥用和酗酒的重要问题。获取组织向任何获得机构道德批准的研究人员开放。组织请求由 NIAAA 召集了科学审查委员会，以确保资源的适当和有效利用。这 BTRC 获得机构伦理批准，可以收集、保存和分发组织及相关临床数据。其运营由主任 Jillian Kril 教授和副主任 Greg 博士监督 Sutherland 和经理 Donna Sheedy 女士在生物样本库方面拥有丰富的经验在他们的职业生涯中，在酒精研究领域发表了 70 多篇出版物。一个悉尼大学任命的管理委员会负责监督和指导 BTRC。悉尼大学为银行的办公和运营提供基础设施。自从自 2000 年成立以来，BTRC 已推动了 110 多个研究项目，并取得了 207 关于酒精滥用和酗酒各个方面的出版物。此外，项目还有为194名学生的研究学位做出了贡献。 BTRC 还向以下组织提供组织和数据：关于神经和精神疾病其他方面的研究项目，这些项目已导致另外 300 多篇出版物。