Brain Tissue Resource Centre for Alcohol Research

酒精研究脑组织资源中心

基本信息

批准号：
9333063
负责人：
Jillian June Kril
金额：
$ 46.08万
依托单位：
UNIVERSITY OF SYDNEY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9333063
关键词：
Address Advanced Development Affect Alcohol abuse Alcohol consumption Alcohol-Related Disorders Alcoholic beverage heavy drinker Alcoholism Alcohols Anatomy Area Automobile Driving Autopsy Biological Biology Brain Brain Injuries Brain region Cirrhosis Clinical Communities Comorbidity Consent DSM-IV Data Developing Countries Development Diabetes Mellitus Disease Economics Epigenetic Process Ethanol toxicity Ethics Facility Accesses Forensic Medicine Formalin Freezing Goals Government Health Human Individual Injury Institutional Ethics Knowledge Laboratories Life Style Malignant Neoplasms Management Information Systems Medical Mental Depression Mental disorders Mission Nerve Degeneration Neuraxis Neurosciences Neurosciences Research New South Wales Nucleus Accumbens Organ Outcomes Research Pathologic Pathology Pattern Physiological Positioning Attribute Predisposition Preparation Prevention Prevention strategy Process Protocols documentation Public Health Radiology Specialty Recording of previous events Research Research Methodology Research Personnel Research Project Grants Resources Role Schizophrenia Smoker Societal Factors Standardization Structure Techniques Tissue Donors Tissues Training Universities addiction alcohol consequences alcohol measurement alcohol research alcohol use disorder biobank brain tissue case control cohort design drinking exhaust experience human tissue innovation interest neuropathology non-smoker prevent problem drinker programs prospective public health relevance research study screening social socioeconomics sound suicidal behavior therapy development tissue resource treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Alcohol-related disorders are areas of major public health and socio-economic concern. Research aimed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol abuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from alcoholic subjects and matched controls. The New South Wales Tissue Resource Center (NSW TRC) at the University of Sydney is an established brain bank that focuses on facilitating research into alcoholism, alcohol-related brain damage and associated conditions. Since its inception the NSW TRC has provided tissue for over 150 research projects. The aim of this innovative facility is to continue o provide fresh-frozen and formalin fixed tissue to research groups in the USA and worldwide who are studying alcohol use disorders. Tissue is collected, with appropriate consent, from forensic autopsies and through a prospective brain donor program, Using our Brains. The donors have lifestyle, medical and psychiatric histories fully documented. Access is open to any researcher with institutional ethics approval. In addition to providing researchers with tissue, the NSW TRC takes a leading role in the area of brain banking by researching methods for enhancing tissue quality, developing standardized preparation protocols, undertaking meticulous clinical characterization of cases, building better information management systems and training staff. Brain banking is a long-term endeavor and maximum benefits will be seen as the number of researchers accessing the facility increases. Multiple research groups using the same case material and applying different questions or techniques will serve to amplify the outcomes of the research. Furthermore, because of the extensive characterization of cases, research groups can generate data that can be related to clinical, laboratory and radiological information. Taken together the provision of high quality, appropriately prepared tissue to researchers will help address the important health problem caused by alcohol abuse. There is strong support for this facility from both the public and the research community.

描述（由申请人提供）：与酒精有关的疾病是主要公共卫生和社会经济关注的领域。旨在防止成瘾和器官损伤的研究，尤其是与酒精相关的脑损伤（ARBD），必须以对细胞水平的酒精滥用生物学的认识为基础。此类研究取决于从酒精受试者和匹配的对照组中获得高质量，广泛表征组织的机会。悉尼大学的新南威尔士组织资源中心（NSW TRC）是一家既定的脑库，致力于促进酒精中毒，酒精相关的脑损伤和相关状况的研究。自成立以来，新南威尔士州TRC为150多个研究项目提供了组织。这种创新设施的目的是继续o为正在研究酒精使用障碍的美国和全球的研究小组提供新鲜冷冻和福尔马林固定组织。在适当同意的情况下，从法医尸检和通过我们的大脑通过前瞻性脑供体计划收集组织。捐助者拥有充分记录的生活方式，医学和精神病学历史。获得机构伦理批准的任何研究人员都可以访问。除了为研究人员提供组织外，新南威尔士州TRC还通过研究提高组织质量，制定标准化的制备方案的方法，对案例进行细致的临床表征，建立更好的信息管理系统和培训人员的精心临床表征，在大脑银行业务领域发挥领导作用。大脑银行业务是一项长期努力，随着进入设施的研究人员的数量增加，将被视为最大收益。使用相同案例材料并应用不同问题或技术的多个研究小组将有助于扩大研究的结果。此外，由于病例的广泛表征，研究组可以生成可能与临床，实验室和放射学信息有关的数据。汇总提供高质量，适当准备的组织向研究人员提供的，将有助于解决酗酒引起的重要健康问题。公众和研究界都有强烈的支持。