Brain Tissue Resource Center for Alcohol Research

酒精研究脑组织资源中心

基本信息

批准号：
10460414
负责人：
Jillian June Kril
金额：
$ 45.09万
依托单位：
UNIVERSITY OF SYDNEY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2023-09-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460414
关键词：
Address Alcohol consumption Alcohol dependence Alcohol-Related Disorders Alcoholism Alcohols Amygdaloid structure Animals Area Autopsy Biology Brain Brain Injuries Brain region Cardiovascular Diseases Cessation of life Clinical Clinical Data Clinical Research Collection Complex Consent Consumption DSM-V Data Development Diagnosis Disease Drug usage Ensure Ethanol Exclusion Criteria Family Forensic Medicine Formalin Freezing Functional disorder Funding Genetic Predisposition to Disease Goals Government Health Care Costs Human Individual Infrastructure Institutional Ethics Knowledge Laboratories Life Style Liver Cirrhosis Liver diseases Magnetic Resonance Imaging Measures Medical Medical Records Mental Depression Mental disorders Methods Modification Molecular Monitor National Institute on Alcohol Abuse and Alcoholism Neurobiology Neurosciences Research Nucleus Accumbens Organ Outcomes Research Paraffin Embedding Patients Persons Protocols documentation Provider Public Health Publications Recording of previous events Recovery Research Research Design Research Methodology Research Personnel Research Project Grants Research Technics Resources Sampling Scanning Services Slide Societies Source Students Substance Use Disorder Techniques Test Result Tissue Banks Tissues Translational Research Universities Ventral Tegmental Area addiction alcohol consequences alcohol misuse alcohol research alcohol use disorder base biobank brain circuitry brain research brain tissue career case control cigarette smoking cognitive testing cohort comorbidity data archive data sharing design disorder control experience health economics illicit drug use improved inclusion criteria nervous system disorder next generation novel operation preclinical study prevent preventable death problem drinker professor programs prospective recruit relating to nervous system research study societal costs socioeconomics sound tissue resource treatment program

项目摘要

Project Summary Alcohol-related disorders are areas of major public health and socio-economic concern. Research aimed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol misuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from individuals with alcohol use disorders and matched controls. The NSW Brain Tissue Resource Center (BTRC) is a brain bank that was established to facilitate research into alcohol addiction and ARBD. It provides human post-mortem brain tissue, and associated clinical information, to researchers worldwide. Tissues are collected from individuals with alcohol use disorders and controls through a prospective donor program or from people undergoing forensic autopsy. Collection of tissue is closely monitored using a range of inclusion and exclusion criteria so as to maintain tissue quality for application to a wide variety research techniques. Tissues are prepared so that fresh frozen, formalin fixed and formalin fixed, paraffin embedded samples are available to researchers. Cases undergo a thorough neuropathologic examination and are assigned DSMIV and DSM 5 diagnoses following review of medical records and medical, family history and lifestyle information provided by the donor and/or their family. Cohorts of alcoholics and controls with and without complicating factors (e.g. comorbid cigarette smoking, liver disease or depression) are then established to allow researchers to tailor their study design to address questions of importance for alcohol misuse and alcoholism. Access to tissue is open to any researcher with institutional ethics approval. Requests for tissue are reviewed by an NIAAA convened Scientific Review Board to ensure appropriate and efficient use of the resource. The BTRC holds institutional ethics approval to collect, hold and distribute tissues and associated clinical data. Its operations are overseen by a Director, Professor Jillian Kril, Deputy Director, Dr Greg Sutherland, and Manager, Ms Donna Sheedy, all of whom have extensive experience in biobanking and have, over their careers, contributed more than 70 publications in the area of alcohol research. A Management Committee appointed by the University of Sydney provides oversight and guidance to the BTRC. The University of Sydney provides the infrastructure to house and operate the bank. Since its inception in 2000 the BTRC has facilitated over 110 research projects that have resulted in 207 publications on various aspects of alcohol misuse and alcoholism. In addition, projects have contributed to the research degrees of 194 students. The BTRC also contributes tissue and data to research projects on other aspects of neurological and psychiatric disease that have resulted in an addition 300+ publications.

项目摘要与酒精有关的疾病是主要的公共卫生和社会经济关注的领域。研究旨在防止成瘾和器官损害，尤其是酒精相关的脑损伤（ARBD），必须以对细胞水平滥用酒精滥用的生物学的认识来支持。这样的研究取决于获得高质量，广泛表征的组织酒精使用障碍和匹配的控件。新南威尔士州脑组织资源中心（BTRC）是旨在促进酒精成瘾和ARBD研究的脑库。它提供人类验尸后脑组织以及与全球研究人员相关的临床信息。通过前瞻性从患有酒精使用障碍和对照的人那里收集组织捐助者计划或接受法医尸检的人。密切监测组织的收集使用一系列包含和排除标准，以维持组织质量以应用于各种各样的研究技术。制备组织，使得新鲜冷冻，福尔马林固定和福尔马林固定的石蜡嵌入样品可供研究人员使用。案件经历了彻底的神经病理检查，并在审查后被分配DSMIV和DSM 5诊断医疗记录和医疗，家族史和生活方式信息由捐助者和/或其提供的信息家庭。酗酒者和对照组，有和没有复杂因素（例如合并症然后建立吸烟，肝病或抑郁症），以允许研究人员量身定制研究设计，以解决对滥用酒精和酒精中毒的重要性问题。进入组织获得机构伦理批准的任何研究人员开放。组织的请求通过 NIAAA召集了科学审查委员会，以确保对资源的适当有效使用。这 BTRC持有机构伦理批准，以收集，持有和分发组织和相关的临床数据。它的业务由董事，副主任，Greg博士负责监督。 Sutherland和经理Donna Sheedy女士，他们在生物库中都有丰富的经验并且在他们的职业生涯中，在酒精研究领域贡献了70多家出版物。一个悉尼大学任命的管理委员会提供了监督和指导 BTRC。悉尼大学提供基础设施来容纳和经营银行。自从 BTRC于2000年成立，已促进了110多个研究项目，这些项目已导致207 关于滥用酒精和酒精中毒的各个方面的出版物。此外，项目有为194名学生的研究学位做出了贡献。 BTRC还为组织和数据贡献关于神经和精神病其他方面的研究项目，导致了增加了300多个出版物。