Brain Tissue Resource Centre for Alcohol Research

酒精研究脑组织资源中心

基本信息

批准号：
8600457
负责人：
Jillian June Kril
金额：
$ 48.25万
依托单位：
UNIVERSITY OF SYDNEY
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8600457
关键词：
Address Advanced Development Affect Alcohol abuse Alcohol consumption Alcohol-Related Disorders Alcoholic beverage heavy drinker Alcoholism Alcohols Anatomy Area Automobile Driving Autopsy Biological Biology Brain Brain Injuries Brain region Cirrhosis Clinical Communities Comorbidity Consent DSM-IV Data Developed Countries Developing Countries Development Diabetes Mellitus Disease Epigenetic Process Ethanol toxicity Facility Accesses Forensic Medicine Formalin Freezing Goals Government Health Human Individual Injury Institutional Ethics Knowledge Laboratories Life Style Malignant Neoplasms Management Information Systems Medical Mental Depression Mental disorders Mission Nerve Degeneration Neuraxis Neurosciences Neurosciences Research New South Wales Nucleus Accumbens Organ Outcomes Research Pathology Pattern Physiological Positioning Attribute Predisposition Preparation Prevention Prevention strategy Process Protocols documentation Public Health Recording of previous events Research Research Methodology Research Personnel Research Project Grants Resources Role Schizophrenia Smoker Societal Factors Structure Techniques Tissue Donors Tissues Training Universities addiction alcohol research alcohol use disorder base biobank brain tissue case control cohort design drinking exhaust experience health economics human tissue innovation interest meetings neuropathology non-smoker prevent problem drinker programs prospective research study screening social socioeconomics sound suicidal behavior tissue fixing tissue resource treatment strategy

项目摘要

Alcohol-related disorders are areas of major public health and socio-economic concern. Research aimed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol abuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from alcoholic subjects and matched controls. The New South Wales Tissue Resource Center (NSW TRC) at the University of Sydney is an established brain bank that focuses on facilitating research into alcoholism, alcohol-related brain damage and associated conditions. Since its inception the NSW TRC has provided tissue for over 150 research projects. The aim of this innovative facility is to continue o provide fresh-frozen and formalin fixed tissue to research groups in the USA and worldwide who are studying alcohol use disorders. Tissue is collected, with appropriate consent, from forensic autopsies and through a prospective brain donor program, Using our Brains. The donors have lifestyle, medical and psychiatric histories fully documented. Access is open to any researcher with institutional ethics approval. In addition to providing researchers with tissue, the NSW TRC takes a leading role in the area of brain banking by researching methods for enhancing tissue quality, developing standardized preparation protocols, undertaking meticulous clinical characterization of cases, building better information management systems and training staff. Brain banking is a long-term endeavor and maximum benefits will be seen as the number of researchers accessing the facility increases. Multiple research groups using the same case material and applying different questions or techniques will serve to amplify the outcomes of the research. Furthermore, because of the extensive characterization of cases, research groups can generate data that can be related to clinical, laboratory and radiological information. Taken together the provision of high quality, appropriately prepared tissue to researchers will help address the important health problem caused by alcohol abuse. There is strong support for this facility from both the public and the research community.

酒精相关疾病是主要的公共卫生和社会经济问题领域。旨在预防成瘾和器官损伤，特别是酒精相关脑损伤（ARBD）的研究必须以细胞水平上酒精滥用生物学的良好知识为基础。此类研究依赖于从酒精受试者和匹配对照中获得高质量、广泛表征的组织。悉尼大学新南威尔士州组织资源中心 (NSW TRC) 是一个成熟的脑库，专注于促进酗酒、酒精相关脑损伤和相关病症的研究。自成立以来，新南威尔士州 TRC 已为 150 多个研究项目提供组织。该创新设施的目的是继续向美国和世界各地研究酒精使用障碍的研究小组提供新鲜冷冻和福尔马林固定的组织。在获得适当同意的情况下，通过法医尸检并通过前瞻性大脑捐赠计划“使用我们的大脑”收集组织。捐赠者的生活方式、医疗和精神病史都有完整的记录。任何获得机构道德批准的研究人员都可以访问。除了为研究人员提供组织外，新南威尔士州 TRC 还通过研究提高组织质量的方法、制定标准化制备方案、对病例进行细致的临床表征、建立更好的信息管理系统和培训人员，在脑库领域发挥主导作用。脑库是一项长期的工作，随着使用该设施的研究人员数量的增加，将看到最大的效益。多个研究小组使用相同的案例材料并应用不同的问题或技术将有助于扩大研究结果。此外，由于病例的广泛特征，研究小组可以生成与临床、实验室和放射学信息相关的数据。总而言之，向研究人员提供高质量、适当制备的组织将有助于解决由酗酒引起的重要健康问题。该设施得到了公众和研究界的大力支持。