The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program

罗伯特·T·马利森耶鲁-朱拉隆功压力、酒精使用和精神病理学培训计划

• 批准号: 10665205
• 负责人: JOEL GELERNTER
• 金额: $ 24.69万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665205
• 关键词: Address; Affect; Alcohol consumption; Alcohols; Chronic; Clinical; Clinical Trials; Collaborations; Communities; Dedications; Developing Countries; Development; Disease; Drug Addiction; Economics; Environment; Faculty; Fellowship; Genetic; Genetic study; Goals; Health; Health Professional; Hospitals; Income; Infrastructure; Institution; Interdisciplinary Study; International; Lead; Medical Care Costs; Medicine; Mental disorders; Molecular Biology; Names; Policy Research; Population; Postdoctoral Fellow; Prevention; Psychiatry; Psychopathology; Psychopharmacology; Public Health; Recording of previous events; Research; Research Personnel; Research Training; Scientist; Site; Stress; Substance Use Disorder; Thailand; Training; Training Programs; Translational Research; Universities; clinical translation; community based participatory research; design; economic disparity; experience; implementation research; medical schools; multidisciplinary; neuroimaging; pre-doctoral; prevent; programs; social; stress related disorder

Abstract Psychiatric disorders are a set of chronic, non-communicable diseases (NCDs), a global public health problem of enormous economic, social, and medical cost to the international community. Stress, alcohol use and other factors (social and environmental; physical disorders) often exacerbate psychiatric disorders. Low and middle income and developing countries are disproportionately affected due to both economic disadvantages and the less well-established institutional infrastructures dedicated to the understanding, treatment and prevention of psychopathology. We propose a collaborative research training program in the multidisciplinary, translational research of stress, alcohol use and psychopathology between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (the lead Thai site) Phramongkutklao (PMK) Hospital, also in Bangkok, and Prince of Songkla University (PSU) in Hat Yai, Thailand; and the Yale University School of Medicine in the U.S. The project is directed by leaders in Thailand and the US, Dr. Kalayasiri at Chulalongkorn, and Drs. Potenza and Gelernter at Yale, mPIs for this application. Three major training mechanisms are proposed for Thai trainees, including long- term (1-2-yr) predoctoral and postdoctoral fellowships, and short-term (1-6 month) fellowships. During the five- year program, training responsibility increases at Chulalongkorn, PMK, and PSU (as experience builds) and decreases at Yale. This program builds on an extensive research program in Psychiatry at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics and clinical correlates of psychopathology (especially substance use disorders) in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn, PMK and PSU and more generally in Thailand to conduct state-of-the-art research in interdisciplinary and translational research in psychiatry through a range of training experiences (genetics, molecular biology, clinical, developmental, psychopharmacology, clinical trials, neuroimaging, implementation, community, and policy research); and has strong ongoing potential for clinical translation. The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating Thai institutions to better understand, treat, and prevent the NCDs of psychiatric illnesses. This training program is also specifically designed to serve a major public health purpose by enhancing Thailand’s capacity to confront major health concerns including alcohol and other stress-related disorders that are unprecedented in Thailand’s history. The context of this program is a long-term research and training collaboration between Yale and Chulalongkorn that focused on drug dependence which was co-led by at Yale by Drs. Gelernter and Malison. This new program with a new focus is expanded in scope to address the needs of Thailand better and include a Thai mPI, and is now named “The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program” for Dr. Malison, who passed in July, 2020.

抽象的 精神疾病是一组慢性，非通信疾病（NCD），这是一个全球公共卫生问题 国际社会的巨大经济，社会和医疗费用。压力，饮酒和其他 因素（社会和环境；身体疾病）常常加剧精神疾病。低和中间 收入和发展中国家由于经济缺陷而受到不成比例的影响 不太公认的机构基础设施致力于理解，治疗和预防 心理病理学。我们提出了一个多学科，翻译的协作研究培训计划 研究压力，饮酒和心理病理学的研究 泰国曼谷（泰国领先地点）也在曼谷的Phramongkutklao（PMK）医院和桑克拉亲王 泰国Hat Yai的大学（PSU）；美国耶鲁大学医学院该项目是 由泰国和美国的领导人执导，在Chulalongkorn的Kalayasiri博士和博士。 Potenza和Gelernter 耶鲁大学，此应用程序的MPI。提出了针对泰国训练的三种主要培训机制，包括长期 学期（1-2岁）前和博士后奖学金以及短期（1-6个月）奖学金。在五个期间 年度计划，Chulalongkorn，PMK和PSU的培训责任（随着体验的建设）和 耶鲁大学下降。该计划以耶鲁大学学校的精神病学广泛研究计划为基础 耶鲁大学调查人员与研究人员之间的现有培训和研究合作 在Chulalongkorn的遗传学和临床相关性研究中 在泰国人群中使用疾病）。该计划将有助于调查员在丘拉隆科恩（Chulalongkorn）的能力， PMK和PSU以及泰国更普遍地在跨学科和 通过一系列培训经验（遗传学，分子生物学，临床，， 发育，心理药理学，临床试验，神经影像学，实施，社区和政策 研究）;并具有持续的临床翻译潜力。该计划的明确长期目标将 建立具有专业知识的科学家，卫生专业人员和学者的批判性和可持续性 合作的泰国机构的研究环境，以更好地理解，治疗和防止 精神病。该培训计划还专门设计用于实现主要公共卫生目的 通过增强泰国面对重大健康问题在内的能力，包括酒精和其他与压力有关 泰国历史上史无前例的疾病。该计划的背景是一项长期研究， 耶鲁大学和Chulalongkorn之间的培训合作，重点是毒品依赖 在耶鲁大学博士。 Gelernter和Malison。这个具有新焦点的新程序在范围中扩展了 泰国的需求更好，包括泰国MPI，现在被命名为“罗伯特·马利森·耶鲁·杜拉隆龙龙” Malison博士于2020年7月通过了压力，饮酒和心理病理学培训计划”。