Genetics of Alcohol Dependence in African Americans: Recruitment

非裔美国人酒精依赖的遗传学：招募

• 批准号: 9769607
• 负责人: JOEL GELERNTER
• 金额: $ 39.55万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9769607
• 关键词: Acute; Address; Affect; African; African American; Alcohol Withdrawal Delirium; Alcohol dependence; Alcohol withdrawal syndrome; Chromosome Mapping; Clinical; Collection; Communities; Comorbidity; Complex; Dangerousness; Data; Diagnosis; Ethics; Funding; Future; Genes; Genetic; Genomic Segment; Genomics; Genotype; Heritability; Individual; Investigation; Medical; Outcome; Pennsylvania; Phenotype; Population; Recording of previous events; Reporting; Research Project Grants; Resources; Sampling; Sampling Studies; Societies; Substance Use Disorder; Time; United States; Universities; Variant; Work; alcohol effect; alcohol risk; base; cost; follow-up; genome wide association study; genome-wide; high risk sexual behavior; improved; recruit; risk variant; study population; trait

ABSTRACT Prevalent alcohol dependence (AD) in the United States, which has increased substantially over the past decade, is highly destructive and costly to individuals and to society. It is also moderately heritable. Delirium tremens (DTs) is a frequent, and often dangerous, consequence of acute alcohol withdrawal. We previously conducted an AD research project focused on the understudied African-American (AA) population and carried out numerous investigations including a pioneering genomewide association study (GWAS) of AD. We also reported GWAS of numerous related traits. Our findings included genomewide significant (GWS) risk loci associated to AD and related traits; our preliminary data support a risk locus for DTs at UNC13C (P= 9.4×10[-9]). Many significant findings, including the DT association, are seen exclusively in AAs. Additional recruitment of AA AD subjects with a state-of-the-art assessment is necessary. Deep phenotyping will make available other relevant related phenotypes, such as risky sexual behavior. New recruitment will build upon our existing sample to increase gene-mapping power not just for AD, but also for other substance use disorder (SUD) traits that are highly comorbid with AD in clinical populations. This resource will enable replication and a more detailed and broader investigation of identified associations. The focus on AA subjects will (a) help to address the well-recognized disparity in complex trait studies of this population; (b) allow us to follow-up GWAS results in the specific population where most of our significant results have been observed (pending future funding); and (c) increase power through greater homogeneity of the study sample. Our new subjects (pending future projects to allow genotyping and analysis based on the subjects to be collected here) will be added to the Psychiatric Genomics Consortium sample to improve the power of their SUD mega-analyses.

抽象的 在过去的十年中，美国的普遍依赖（AD）对个人和社会来说都是高度破坏性和昂贵的。它也是中等的遗传。 del妄（DTS）是急性饮酒的结果，经常是且经常危险的。我们以前进行了一个集中在知识的非洲裔美国人（AA）人口的广告研究项目，并进行了许多投资，包括AD的开创性基因组协会研究（GWAS）。我们还报道了许多相关特征的GWA。我们的发现包括与AD和相关性状相关的基因组重要（GWS）风险基因座；我们的初步数据支持在UNC13C处的DTS风险基因座（p = 9.4×10 [-9]）。在AAS中仅看到许多重要的发现，包括DT关联。 需要对AA广告主体进行额外的招募，并进行最先进的评估。深层表型将使其他相关的表型（例如风险的性行为）提供。新招聘将建立在我们现有样本的基础上，以增加基因映射能力，不仅用于AD，而且还增加了其他药物使用障碍（SUD）特征，这些特征与临床人群中的AD高度合并。该资源将实现复制，并对已确定的关联进行更详细和更详细的广播公司调查。对AA受试者的关注将（a）帮助解决该人群的复杂特征研究中公认的差异； （b）允许我们跟进GWAS在观察到大多数重要结果的特定人群中（未来的资金）； （c）通过更大的研究样本来增加功率。我们的新主题（未来的项目允许基于基于此处收集的受试者的基因分型和分析）将添加到精神病基因组学联盟样本中，以提高其SUD大型分析的力量。