Properties and Applications of Fluoride-Calcium-Phosphate Complex

氟钙磷酸盐络合物的性质及应用

• 批准号: 7963780
• 负责人: LAURENCE C. CHOW
• 金额: $ 18.75万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963780
• 关键词: Apatites; Binding; Calcium Fluoride; Chemicals; Chemistry; Child; Citrates; Clinical; Complex; Dental Enamel; Dentifrices; Deposition; Development; Diphosphates; Dose; Drug Formulations; Evaluation; Exposure to; Fluoride Ion; Fluorides; Future; Gel; Human; In Situ; In Vitro; Ionic Strengths; Ions; Lead; Measurement; Measures; Methods; Minerals; Modeling; Nature; Oral; Oral cavity; Outcome; Phase; Precipitation; Preparation; Process; Property; Regimen; Research; Saliva; Solutions; Source; Structure; Surface; Titrations; Tooth structure; Topical application; Water; anticaries; base; calcium phosphate; demineralization; design; frontier; improved; in vitro Model; in vivo; inhibitor/antagonist; inorganic phosphate; insight; public health relevance; remineralization

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2 and F-containing apatitic (F-Ap) minerals. Preliminary results showed the feasibility of using FCaP for developing higher efficacy F regimens without increasing the F dose, or with a lower F dose. In order to achieve this objective, it is necessary to obtain a better understanding of the FCaP complex itself. Specifically, what are the composition ranges in which stable FCaP can exist? What is the structure of FCaP, What are the factors that destabilize FCaP, leading to precipitation? We propose to conduct studies aimed at gaining insights into these questions through the following Aims: Aim 1 - Preparation and characterization of FCaP complex formed under a wide range of solution compositions. Aim 2 - Factors that destabilize FCaP complex leading to precipitation and characterization of the precipitation products. Aim 3 - Initial Evaluation of F deposition produced by FCaP complex solutions in an in vitro model. Successful outcome of the proposed research can open new frontiers of future research aimed at improving the anticaries efficacy of F while decreasing the F strength and is safer to used, especially for children. PUBLIC HEALTH RELEVANCE: We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions that simultaneously contain desired levels of all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation. The FCaP solutions can be triggered to precipitate F reservoirs in the mouth. Successful outcome of the proposed research can lead to development of new ultra effective oral rinses, dentifrices, gels, and F-containing calcium phosphate remineralizing products with a lower F strength in the product, and therefore is safer to use.

DESCRIPTION (provided by applicant): We propose to study a newly discovered fluoride-calcium-phosphate (FCaP) complex that allows preparation of solution compositions simultaneously containing all there tooth mineral ions: fluoride, calcium, and phosphate, without precipitation The FCaP solutions can be triggered to precipitate phosphate-contaminated calcium fluoride (hereafter abbreviated as CaF2) alone or CaF2和含F的Apatitic（F-AP）矿物质。初步结果表明，使用FCAP在不增加F剂量或较低F剂量的情况下使用FCAP开发较高的功效F方案。为了实现这一目标，有必要更好地了解FCAP复合物本身。具体来说，稳定的FCAP可以存在哪些组成范围？ FCAP的结构是什么，导致FCAP稳定的因素是什么？我们建议通过以下目的进行旨在了解这些问题的研究：目标1-在各种溶液组成下形成的FCAP复合物的制备和表征。 AIM 2-破坏FCAP复合物的因素，导致降水和降水产物的表征。 AIM 3-对FCAP复合溶液在体外模型中产生的F沉积的初步评估。拟议的研究的成功结果可以为未来研究的新领域开放，旨在提高F的抗药性功效，同时降低F强度并更安全使用，尤其是对于儿童而言。 公共卫生相关性：我们建议研究新发现的氟化钙磷酸盐（FCAP）复合物，该配合物允许制备溶液组成，同时含有所有牙齿矿物质的所需水平：氟化物，钙和磷酸盐，无降水。可以触发FCAP溶液以使F储存液在口腔中。拟议的研究的成功结果可以导致新的超有效口服冲洗，牙齿，凝胶和含磷酸钙的含磷酸钙的产物，以较低的F强度在产品中，因此使用更安全。