CALCIUM PHOSPHATE CEMENTS

磷酸钙水泥

• 批准号: 2701014
• 负责人: LAURENCE C. CHOW
• 金额: $ 14.45万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2701014
• 关键词: bicarbonates; biomaterial development /preparation; biomaterial evaluation; biomechanics; calcium phosphate; cementum; crystallization; dental bonding material; hardness; hydroxyapatites; potassium; sodium; solid state; solubility; solutions; stoichiometry; tensile strength

Self-hardening calcium phosphate cements (CPC), developed under a NIH grant (DE05030), have proven useful in a number of dental and medical applications for which currently available materials do not work well. Results from animal studies indicated that improvements in several key properties of CPC can significantly increase the usefulness of the cement in clinical applications. The objectives of the proposed research are to elucidate mechanisms of reactions between calcium phosphate compounds that form cements and to understand physicochemical and mechanical properties of the cements formed under different conditions. The specific aims are: 1. To study the crystallinity, solubility, and rate of dissolution of the nearly stoichiometric hydroxyapatite (OHAp) formed in different cement systems and in CPCs that harden slowly or rapidly. Additionally, to determine the mechanical properties of the cements formed under these conditions. 2. To study the degree of Ca-deficiency, crystallinity, solubility, and rate of dissolution of OHAp formed in cements that have an overall Ca/P molar ratio below 1.67, and to study the mechanical properties of these cements. 3. To study the extent and the nature of carbonate incorporation, crystallinity, solubility, and rate of dissolution of OHAp formed in different cement systems and with either sodium or potassium as the cationic component of the carbonate source. 4. To study the rate of dissolution of cements that contain varied amounts of micropores (pore size of lessor 1 mum) and micropores (pore size of 150 2 200 mum). The information obtained from the proposed should be valuable in designing CPCs with specific in vitro and in vivo properties that are best suited for different types of clinical applications.

在NIH赠款下开发的磷酸钙钙水泥（CPC） （DE05030）已被证明在许多牙科和医疗中很有用 当前可用材料的应用程序无法正常工作。 动物研究的结果表明，几个关键的改善 CPC的性质可以显着提高水泥的实用性 在临床应用中。 拟议研究的目标是 阐明磷酸钙化合物之间反应机制 形成水泥，并了解物理化学和机械性能 在不同条件下形成的水泥。 具体目的是： 1。研究结晶度，溶解度和溶解速率 在不同水泥中形成的几乎化学计量羟基磷灰石（OHAP） 系统和CPC在缓慢或快速变化的CPC中。 此外， 确定在这些水泥下形成的水泥的机械​​性能 状况。 2。研究ca缺陷，结晶度，溶解度和 在具有总体CA/P的水泥中形成的OHAP的溶解速率 摩尔比低于1.67，并研究了这些的机械性能 水泥。 3。研究碳酸盐掺入的程度和性质， OHAP形成的结晶度，溶解度和溶解速率 不同的水泥系统以及钠或钾 碳酸盐源的阳离子成分。 4。研究包含不同量的水泥的溶解速率 微孔（出租人1妈妈的孔径）和微孔（孔径为150） 2 200妈妈）。 从拟议的信息中获得的信息对于设计应该很有价值 具有特定体外和体内特性的CPC，最适合 不同类型的临床应用。