NANOSTRUCTURED BIOACTIVE MATERIALS

纳米结构生物活性材料

基本信息

批准号：
7034959
负责人：
LAURENCE C. CHOW
金额：
$ 21.38万
依托单位：
AMERICAN DENTAL ASSOCIATION FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7034959
关键词：
calcium clinical research dentin heat model particle phosphates reduction solutions solvents

项目摘要

DESCRIPTION (provided by applicant): Nano forms of hydroxyapatite, other calcium phosphate compounds, and additional bioactive inorganic materials will be prepared by a newly developed method, employing either a spray drying or a flame pyrolysis technique in such a way that (1) target particle sizes over a wide range can be obtained, (2) compounds with both low and high solubilities can be prepared, and (3) the prepared particles would not be exposed to any solution environment after their formation and therefore would retain their original, highly reactive surfaces (Aim 1). Due to their small sizes and high reactivity, the prepared nano materials are expected to have a range of clinical applications. Two of which will be evaluated in Aims 2 and 3. Aim 2 will focus on evaluating the effectiveness of nano forms calcium fluoride (CaF2) as the source of fluoride (F) for remineralizing tooth enamel carious lesions using (1) an in vitro model to understand the relationship between CaF2 particle size and F deposition, (2) an in vivo saliva and plaque model to compare oral F retention produced by the nano CaF2 and currently used NaF rinses, and (3) an in situ demineralization/remineralization model to evaluate the remineralization effects of the nano CaF2 rinse. Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental hypersensitivity.

DESCRIPTION (provided by applicant): Nano forms of hydroxyapatite, other calcium phosphate compounds, and additional bioactive inorganic materials will be prepared by a newly developed method, employing either a spray drying or a flame pyrolysis technique in such a way that (1) target particle sizes over a wide range can be obtained, (2) compounds with both low and high solubilities can be prepared, and (3) the prepared particles would在形成后不受任何解决方案环境的影响，因此将保留其原始的，高反应性的表面（AIM 1）。由于其尺寸很小和反应性高，预计制备的纳米材料将具有一系列临床应用。其中两个将在目标2和3中进行评估。 AIM 2将重点放在评估纳米形成氟化钙（CAF2）的有效性作为氟化钙（F）的来源（F），以回想使用（1）使用（1）体外的牙齿牙釉质龋齿病变，以了解Caf2粒子大小和F沉积之间的关系，（2）在Vivo saliva and vivo saliva和plaque for n nne anf nnaf anf inf anf inf anf inf anf inf inf inf inf inf inf inf inf inf and。（3）一种原位脱矿化/回忆模型，以评估纳米CAF2冲洗的回忆作用。 AIM 3将评估纳米尺寸磷酸钙和氟化钙在降低牙本质渗透性方面的有效性，牙本质的通透性与牙齿超敏反应密切相关。