NANOSTRUCTURED BIOACTIVE MATERIALS

纳米结构生物活性材料

基本信息

批准号：
7371128
负责人：
LAURENCE C. CHOW
金额：
$ 20.53万
依托单位：
AMERICAN DENTAL ASSOCIATION FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7371128
关键词：
Acids Affinity Area Calcium Fluoride Carbonic Acid Chemicals Condition Data Dental Dental Enamel Dentin Dentin Permeability Dentin Sensitivity Deposition Effectiveness Electrostatics Environment Exhibits Fluorides Fourier Analysis Growth High temperature of physical object Hydroxyapatites Hypersensitivity Image In Situ In Vitro Ions Lesion Liquid substance Measurement Methods Modeling Morphology Oral Particle Size Penetration Phase Powder dose form Preparation Process Property Range Reporting Research Personnel Resistance Saliva Sodium Fluoride Solubility Solutions Solvents Source Spectroscopy, Fourier Transform Infrared Surface Techniques Temperature Tooth Remineralization Tooth structure Transmission Electron Microscopy Water calcium hydroxide calcium phosphate clinical application demineralization desensitization dicalcium phosphate anhydrous dicalcium phosphate dihydrate evaporation fluorapatite in vitro Model in vivo in vivo Model interest monocalcium phosphate nano nanocompound nanoforms nanomaterials nanoparticle nanosized nanostructured octacalcium phosphate particle programs remineralization size tetracalcium phosphate tricalcium phosphate

项目摘要

Nano forms of hydroxyapatite, other calcium phosphate compounds, and additional bioactive inorganic materials will be prepared by a newly developed method, employing either a spray drying or a flame pyrolysis technique in such a way that (1) target particle sizes over a wide range can be obtained, (2) compounds with both low and high solubilities can be prepared, and (3) the prepared particles would not be exposed to any solution environment after their formation and therefore would retain their original, highly reactive surfaces (Aim1). Due to their small sizes and high reactivity, the prepared nano materials are expected to have a range of clinical applications. Two of which will be evaluated in Aims 2 and 3. Aim 2 will focus on evaluating the effectiveness of nano forms calcium fluoride (CaF2) as the source of fluoride (F) for remineralizing tooth enamel carious lesions using (1) an in vitro model to understand the relationship between CaF2 particle size and F deposition, (2) an in vivo saliva and plaque model to compare oral F retention produced by the nano CaF2 and currently used NaF rinses, and (3) an in situ demineralization/remineralization model to evaluate the remineralization effects of the nano CaF2 rinse. Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental hypersensitivity.

羟基磷灰石的纳米形式，其他磷酸钙化合物和其他生物活性无机材料将通过新开发的方法制备，采用喷雾干燥或火焰热解技术以（1）可以在较大范围内的目标粒子大小，（2）可以准备低溶解度和高溶解度的化合物，（3）准备的颗粒不会是成立后暴露于任何解决方案环境，因此将保留其原始的，高度反应性表面（AIM1）。由于其小尺寸和高反应性，准备好的纳米材料是预计将有一系列临床应用。其中两个将在目标2和3中进行评估。 AIM 2将着重于评估纳米形成氟化钙（CAF2）的有效性使用（1）体外模型来理解氟化物（F） CAF2粒径与F沉积之间的关系，（2）体内唾液和斑块模型比较纳米CAF2生产并目前使用NAF冲洗的口服f保留率，（3）原位去矿化/回忆模型，以评估纳米CAF2冲洗的回忆作用。 AIM 3将评估纳米尺寸磷酸钙和氟化钙在还原方面的有效性牙本质渗透性，与牙齿超敏反应密切相关的特性。