CALCIUM PHOSPHATE BONE REPAIR MATERIALS

磷酸钙骨修复材料

• 批准号: 6926870
• 负责人: LAURENCE C. CHOW
• 金额: $ 28.12万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6926870
• 关键词: acidity /alkalinity; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomechanics; biotechnology; calcium phosphate; chitin; composite resins; dental bonding material; dogs; elastomers; electron probe spectrometry; endosseous dental implant; hardness; histopathology; hydroxyapatites; mandible /maxilla; oral facial restoration material; physiologic bone resorption; solubility; statistics /biometry; tensile strength

DESCRIPTION (provided by applicant): The first self-hardening calcium phosphate cements (CPCs) were developed in our laboratory under the present and a previous N1H grant. One such CPC material has been in clinical use since 1996 for repairing cranial defects in humans. In recent years, several additional CPCs have been approved by the FDA, but due to limitations in both physical and in vivo properties, their uses remain largely confined to craniofacial and selected non-load bearing orthopedic applications. Through the following Aims, the objective of the present proposal is to determine how to build into CPC materials those attributes that are of critical importance for different applications so that CPC materials can be useful for a wider range of clinical applications. Aim 1. To develop and study the properties of CPCs that form products comprising a wide range of phase compositions and resorption rates suitable for different clinical applications. Aim 2. To develop and study the properties of elastomeric CPC materials that would provide compliance for micro-motions within the tissues and resist fracturing. Materials with these properties should be useful for applications such as periodontal defect repair, ridge augmentation, and spinal fusion. Aim 3. To develop and study the properties of rapid setting moldable/injectable premixed CPCs that are stable in the package and harden at tissue defect site. These CPCs can be more easily delivered to the defect site and possibly with reduced surgical invasions. Aim 4. To evaluate in vivo properties of selected CPC materials developed in the first three Aims in animal models. The following three animal studies will be conducted: (1) Evaluation of in vivo resorption rates of new CPC materials developed in Aim 1 that exhibit a wide range of in vitro acid dissolution rates. The study will employ a dog model, and histopathological measurements and electron microprobe analyses will be used to obtain quantitative data on in vivo resorption/bone replacement rates. (2) Evaluation of in vivo characteristics of non-rigid CPCs developed in Aim 2. The study, employing a dog model, will focus on the biocompatibility and resorption and bone replacement of CPC-chitosan composites in which the CPC and chitosan components have closely matched in vitro acid dissolution rates. (3) Evaluation of premixed, injectable CPC in a dog model to determine biocompatibility and osteoconductivity of these materials, which contain non-calcium phosphate components that have not been evaluated in vivo in previous studies.

描述（由申请人提供）：在我们的实验室和以前的N1H赠款下，在我们的实验室中开发了第一个自塑磷酸钙水泥（CPC）。自1996年以来，一种这样的CPC材料一直用于修复人类的颅骨缺陷。近年来，FDA批准了其他几个CPC，但是由于物理和体内特性的局限性，它们的用途仍在很大程度上仅限于颅面和选定的非载荷轴承骨科应用。通过以下目的，本提案的目的是确定如何在CPC材料中构建这些对不同应用至关重要的属性，以便CPC材料对更广泛的临床应用有用。 目的1。开发和研究CPC的特性，这些CPC形成了包括广泛的相组合物和适合不同临床应用的吸收速率的产品。 目标2。开发和研究弹性体CPC材料的特性，这些材料将为组织内的微动作提供依从性并抵抗破裂。具有这些特性的材料应适用于诸如牙周缺陷修复，脊增强和脊柱融合等应用。 目标3。开发和研究快速设置可塑性/可注射的预混合的CPC的特性，这些CPC在包装中稳定并在组织缺陷部位硬化。这些CPC可以更容易地传递到缺陷部位，并且可能会减少手术入侵。 目标4。评估动物模型前三个目标中开发的选定CPC材料的体内特性。将进行以下三项动物研究：（1）在AIM 1中开发的新CPC材料的体内吸收速率评估，这些材料表现出广泛的体外酸溶解速率。该研究将采用狗模型，组织病理学测量和电子微探针分析将用于获取有关体内吸收/骨骼替代率的定量数据。 （2）评估AIM 2中开发的非刚性CPC的体内特征。采用狗模型的研究将集中于CPC-Chitosan复合材料的生物相容性，吸收性和骨骼替代，其中CPC和壳聚糖成分在中心酸溶解速率中与CPC和壳聚糖成分非常匹配。 （3）评估狗模型中的预混合，可注射的CPC，以确定这些材料的生物相容性和破骨传导性，这些材料包含在先前研究中尚未在体内评估过的非磷酸盐成分。