The Kansas Institute for Precision Medicine

堪萨斯精准医学研究所

基本信息

批准号：
10582647
负责人：
ANDREW K. GODWIN
金额：
$ 224.19万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2024-04-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10582647
关键词：
Address Advisory Committees Applied Research Area Basic Science Biomedical Engineering Biomedical Research Cancer Center Caring Centers of Research Excellence Characteristics Clinic Clinical Collaborations Communities Department chair Development Diagnosis Diagnostic Diet Discipline Disease Education Environment Evolution Faculty Family Fostering Funding Generations Goals Healthcare Individual Infrastructure Institution Internal Medicine Kansas Knowledge Laboratories Leadership Life Style Medical Medical History Medical center Medicine Mentors Methods Mission Molecular Molecular Medicine Molecular Profiling Outcome Participant Pathology Patient Care Patient-Focused Outcomes Patients Peer Review Persons Physicians Precision therapeutics Process Program Sustainability Public Health Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Research Proposals Research Training Resource Sharing Rural Science Scientist Seasons Secure Shapes Training Training Programs Translating Translational Research Universities base biobank biomarker development biomarker validation clinical care clinical practice disparity gap experience human disease implementation barriers improved individualized medicine innovation insight invention medical schools meetings molecular marker next generation novel diagnostics organizational structure personalized diagnostics population health precision medicine programs recruit standard of care tool translational physician translational scientist

项目摘要

ABSTRACT The overall objective of the “Kansas Institute for Precision Medicine” (KIPM) COBRE at the University of Kansas Medical Center (KUMC) is to advance the customization of healthcare through promoting innovative scientific discoveries. The KIPM COBRE will provide support to advance the mission of KUMC through innovative mentoring and training programs with a precision medicine theme. The KIPM COBRE will also strengthen the biomedical research capacity within our region by enhancing the research base and infrastructure/core capacities. To accomplish this, the KIPM COBRE proposes the following Specific Aims: Specific Aim 1. Recruit and mentor a group of outstanding junior investigators in diverse disciplines with different disease focus areas that have a common theme directed toward precision medicine. In a rigorous pre-selection process, five promising junior investigators (and two alternative investigators) were selected from nearly 20 applicants, all of which had a research theme directly related to precision medicine. Decisions were based on the content of research proposals and training potential that were evaluated by our leadership team (including the three PIs of the proposed COBRE, the senior leadership at KUMC including the Dean, department chairs, and past PIs of COBREs within KUMC). Each applicant has been assigned at least one internal and one external mentor with expertise related to their area of study. All COBRE faculty candidates contributed to discussions regarding infrastructure necessary to enhance their projects via one-on-one meetings with the PIs and research core directors were formed based in infrastructure needs to enhance their research capacity. Specific Aim 2. To develop the scientific, technical, mentoring and collaborative infrastructure for a cohesive and sustainable program in precision medicine. Relying on additional expertise afforded by our Internal Advisory Committee (IAC), the External Advisory Committee (EAC), and an interactive mentoring program, we will continue to guide and mentor the next generation of translational scientists to advance molecular medicine in the 21st century with a thematic focus on precision medicine. Four shared resources, i.e., Administrative, Biomedical Engineering (BME), Biobanking and Biomarker Validation (BBV), and Quantitative `Omics' (QO) Cores, will be developed to assist the projects and serve the extended research community in Kansas and beyond. Specific Aim 3. To foster and enhance collaborations between basic scientists and clinicians and facilitate translational research directed toward the development of biomarkers, new diagnostics and/or treatments for human disease. Pilot research projects funded by the School of Medicine, the Departments of Internal Medicine and Pathology and Laboratory Medicine, and the NCI-designated KU Cancer Center, will provide opportunities to identify both senior and junior investigators within our institute to expand the breadth and depth of research in the fields of precision medicine.

抽象的堪萨斯大学“堪萨斯精准医学研究所”(KIPM) COBRE 的总体目标医疗中心 (KUMC) 旨在通过促进创新科学来推进医疗保健的定制化 KIPM COBRE 将通过创新提供支持，推进 KUMC 的使命。 KIPM COBRE 还将加强以精准医学为主题的指导和培训计划。通过加强研究基础和基础设施/核心，提高我们地区的生物医学研究能力为了实现这一目标，KIPM COBRE 提出了以下具体目标：具体目标 1. 招聘并指导一批不同学科、不同疾病重点领域的优秀初级研究者在严格的预选过程中，有五个共同主题针对精准医学。初级研究者（以及两名有前途的替代研究者）是从近 20 名申请者中选出的，全部来自其研究主题与精准医学直接相关。由我们的领导团队（包括三个 PI）评估的研究提案和培训潜力拟议的 COBRE、KUMC 的高级领导层，包括院长、系主任和过去的 PI KUMC 内的 COBRE）已为每位申请人分配了至少一名内部导师和一名外部导师。所有 COBRE 教师候选人都参与了与其研究领域相关的专业知识的讨论。通过与 PI 和研究核心的一对一会议来增强项目所需的基础设施董事的组建是基于基础设施的需要，以提高他们的研究能力。具体目标 2. 开发科学、技术、指导和协作基础设施，以实现有凝聚力和可持续的依靠我们内部咨询委员会提供的额外专业知识。 (IAC)、外部咨询委员会 (EAC) 和互动指导计划，我们将继续指导并指导下一代转化科学家推进 21 世纪的分子医学主题重点是精准医学，即行政、生物医学工程四个共享资源。（BME）、生物样本库和生物标志物验证（BBV）以及定量“组学”（QO）核心将被开发协助项目并为堪萨斯州及其他地区的广泛研究界提供服务具体目标 3. 促进和加强基础科学家和参议员之间的合作并促进转化研究旨在开发人类疾病的生物标志物、新的诊断方法和/或治疗方法。由医学院、内科和病理学系资助的研究项目检验医学和 NCI 指定的 KU 癌症中心将提供识别这两位老年人的机会和我们研究所的初级研究人员扩大精密领域研究的广度和深度药品。